Intermittent intravenous paracetamol versus continuous morphine in infants undergoing cardiothoracic surgery: a multi-center randomized controlled trial.

Autor: Zeilmaker-Roest G; Department of Neonatal and Pediatric Intensive Care, Division of Pediatric Intensive Care, Erasmus MC-Sophia Children's Hospital, Wytemaweg 80, 3015 CN, Rotterdam, The Netherlands. g.zeilmaker@erasmusmc.nl.; Department of Cardiothoracic Surgery, Erasmus MC, Rotterdam, The Netherlands. g.zeilmaker@erasmusmc.nl., de Vries-Rink C; Department of Neonatal and Pediatric Intensive Care, Division of Pediatric Intensive Care, Erasmus MC-Sophia Children's Hospital, Wytemaweg 80, 3015 CN, Rotterdam, The Netherlands.; Department of Cardiothoracic Surgery, Erasmus MC, Rotterdam, The Netherlands., van Rosmalen J; Department of Biostatistics, Erasmus MC, Rotterdam, The Netherlands.; Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands., van Dijk M; Department of Neonatal and Pediatric Intensive Care, Division of Pediatric Intensive Care, Erasmus MC-Sophia Children's Hospital, Wytemaweg 80, 3015 CN, Rotterdam, The Netherlands., de Wildt SN; Department of Neonatal and Pediatric Intensive Care, Division of Pediatric Intensive Care, Erasmus MC-Sophia Children's Hospital, Wytemaweg 80, 3015 CN, Rotterdam, The Netherlands.; Department of Pharmacology and Toxicology, Radboud University Medical Center, Nijmegen, The Netherlands., Knibbe CAJ; Division of Systems Pharmacology and Pharmacy, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands.; Department of Clinical Pharmacy, St. Antonius Hospital Nieuwegein/Utrecht, Utrecht, The Netherlands., Koomen E; Department of Pediatrics, Division of Pediatric Critical Care Medicine, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, The Netherlands., Jansen NJG; Department of Pediatrics, Division of Pediatric Critical Care Medicine, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, The Netherlands.; Department of Pediatrics, Beatrix Children's Hospital, University Medical Center Groningen, Groningen, The Netherlands., Kneyber MCJ; Department of Pediatrics, Division of Pediatric Critical Care Medicine, Beatrix Children's Hospital, University Medical Center Groningen, Groningen, The Netherlands., Maebe S; Department of Pediatrics, Maastricht University Medical Center+, MosaKids Children's Hospital, Maastricht, The Netherlands., Van den Berghe G; Department of Intensive Care Medicine, UZ Leuven, Louvain, Belgium., Haghedooren R; Department of Intensive Care Medicine, UZ Leuven, Louvain, Belgium., Vlasselaers D; Department of Intensive Care Medicine, UZ Leuven, Louvain, Belgium., Bogers AJJC; Department of Cardiothoracic Surgery, Erasmus MC, Rotterdam, The Netherlands., Tibboel D; Department of Neonatal and Pediatric Intensive Care, Division of Pediatric Intensive Care, Erasmus MC-Sophia Children's Hospital, Wytemaweg 80, 3015 CN, Rotterdam, The Netherlands., Wildschut ED; Department of Neonatal and Pediatric Intensive Care, Division of Pediatric Intensive Care, Erasmus MC-Sophia Children's Hospital, Wytemaweg 80, 3015 CN, Rotterdam, The Netherlands.

Publikováno v: Critical care (London, England) [Crit Care] 2024 Apr 30; Vol. 28 (1), pp. 143. Date of Electronic Publication: 2024 Apr 30.

Enteroids to Study Pediatric Intestinal Drug Transport.

Autor: Streekstra EJ; Division of Pharmacology and Toxicology, Department of Pharmacy, Radboud University Medical Center, Nijmegen 6525GA, The Netherlands.; Department of Metabolic Health Research, Netherlands Organization for Applied Scientific Research (TNO), Leiden 2333BE, The Netherlands., Keuper-Navis M; Department of Metabolic Health Research, Netherlands Organization for Applied Scientific Research (TNO), Leiden 2333BE, The Netherlands.; Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences (UIPS), Utrecht University, Utrecht 3584 CS, The Netherlands., van den Heuvel JJMW; Division of Pharmacology and Toxicology, Department of Pharmacy, Radboud University Medical Center, Nijmegen 6525GA, The Netherlands., van den Broek P; Division of Pharmacology and Toxicology, Department of Pharmacy, Radboud University Medical Center, Nijmegen 6525GA, The Netherlands., Stommel MWJ; Department of Surgery, Radboud University Medical Center, Nijmegen 6525GA, The Netherlands., de Boode W; Department of Pediatrics, Division of Neonatology, Radboud University Medical Center, Amalia Children's Hospital, Nijmegen 6525GA, The Netherlands., Botden S; Department of Surgery, Amalia Children's Hospital, Radboud University Medical Center, Nijmegen 6525GA, The Netherlands., Bervoets S; Radboudumc Technology Center for Bioinformatics, Department of Medical BioSciences, Radboud University Medical Center, Nijmegen 6525GA, The Netherlands., O'Gorman L; Radboudumc Technology Center for Bioinformatics, Department of Medical BioSciences, Radboud University Medical Center, Nijmegen 6525GA, The Netherlands., Greupink R; Division of Pharmacology and Toxicology, Department of Pharmacy, Radboud University Medical Center, Nijmegen 6525GA, The Netherlands., Russel FGM; Division of Pharmacology and Toxicology, Department of Pharmacy, Radboud University Medical Center, Nijmegen 6525GA, The Netherlands., van de Steeg E; Department of Metabolic Health Research, Netherlands Organization for Applied Scientific Research (TNO), Leiden 2333BE, The Netherlands., de Wildt SN; Division of Pharmacology and Toxicology, Department of Pharmacy, Radboud University Medical Center, Nijmegen 6525GA, The Netherlands.; Department of Intensive Care, Radboud University Medical Center, Nijmegen 6525GA, The Netherlands.; Department of Neonatal and Pediatric Intensive Care, Erasmus MC Sophia Children's Hospital, Rotterdam 3015 GD, The Netherlands.

Publikováno v: Molecular pharmaceutics [Mol Pharm] 2024 Oct 07; Vol. 21 (10), pp. 4983-4994. Date of Electronic Publication: 2024 Sep 16.

Human enteroid monolayers as a potential alternative for Ussing chamber and Caco-2 monolayers to study passive permeability and drug efflux.

Autor: Streekstra EJ; Division of Pharmacology and Toxicology, Department of Pharmacy, Radboud University Medical Center, P.O. Box 9101, 6500 HB Nijmegen (Route 137), Nijmegen, the Netherlands; Department of Metabolic Health Research, Netherlands Organization for Applied Scientific Research (TNO), Leiden, the Netherlands., Keuper-Navis M; Department of Metabolic Health Research, Netherlands Organization for Applied Scientific Research (TNO), Leiden, the Netherlands; Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences (UIPS), Utrecht University, Utrecht, the Netherlands., van den Heuvel JJMW; Division of Pharmacology and Toxicology, Department of Pharmacy, Radboud University Medical Center, P.O. Box 9101, 6500 HB Nijmegen (Route 137), Nijmegen, the Netherlands., van den Broek P; Division of Pharmacology and Toxicology, Department of Pharmacy, Radboud University Medical Center, P.O. Box 9101, 6500 HB Nijmegen (Route 137), Nijmegen, the Netherlands., Stommel MWJ; Department of Surgery, Radboud University Medical Center, Nijmegen, the Netherlands., Bervoets S; Radboudumc Technology Center for Bioinformatics, Department of Medical BioSciences, Radboud University Medical Center, Nijmegen, the Netherlands., O'Gorman L; Radboudumc Technology Center for Bioinformatics, Department of Medical BioSciences, Radboud University Medical Center, Nijmegen, the Netherlands., Greupink R; Division of Pharmacology and Toxicology, Department of Pharmacy, Radboud University Medical Center, P.O. Box 9101, 6500 HB Nijmegen (Route 137), Nijmegen, the Netherlands., Russel FGM; Division of Pharmacology and Toxicology, Department of Pharmacy, Radboud University Medical Center, P.O. Box 9101, 6500 HB Nijmegen (Route 137), Nijmegen, the Netherlands., van de Steeg E; Department of Metabolic Health Research, Netherlands Organization for Applied Scientific Research (TNO), Leiden, the Netherlands., de Wildt SN; Division of Pharmacology and Toxicology, Department of Pharmacy, Radboud University Medical Center, P.O. Box 9101, 6500 HB Nijmegen (Route 137), Nijmegen, the Netherlands; Department of Intensive Care, Radboud University Medical Center, Nijmegen, the Netherlands; Department of Neonatal and Pediatric Intensive Care, Erasmus MC Sophia Children's Hospital, Rotterdam, the Netherlands. Electronic address: Saskia.dewildt@radboudumc.nl.

Publikováno v: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences [Eur J Pharm Sci] 2024 Oct 01; Vol. 201, pp. 106877. Date of Electronic Publication: 2024 Aug 16.

A User-Driven Framework for Dose Selection in Pregnancy: Proof of Concept for Sertraline.

Autor: Koldeweij C; Division of Pharmacology and Toxicology, Department of Pharmacy, Radboud University Medical Center, Nijmegen, The Netherlands., Dibbets C; Division of Pharmacology and Toxicology, Department of Pharmacy, Radboud University Medical Center, Nijmegen, The Netherlands.; Department of Obstetrics and Gynaecology, Maastricht University Medical Centre, Maastricht, The Netherlands., Franklin BD; Centre for Medication Safety and Service Quality, Imperial College Healthcare NHS Trust, London, UK.; Department of Practice and Policy, UCL School of Pharmacy, London, UK., Scheepers HCJ; Department of Obstetrics and Gynaecology, Maastricht University Medical Centre, Maastricht, The Netherlands.; Grow, School for Oncology and Reproduction, Maastricht, The Netherlands., de Wildt SN; Division of Pharmacology and Toxicology, Department of Pharmacy, Radboud University Medical Center, Nijmegen, The Netherlands.; Department of Pediatric and Neonatal Intensive Care, Erasmus MC-Sophia Children's Hospital, Rotterdam, The Netherlands.

Publikováno v: Clinical pharmacology and therapeutics [Clin Pharmacol Ther] 2024 Sep 09. Date of Electronic Publication: 2024 Sep 09.

Willingness-to-use and preferences for model-informed antenatal doses: a cross-sectional study among European healthcare practitioners and pregnant women.

Autor: Koldeweij CJM; Division of Pharmacology and Toxicology, Department of Pharmacy, Radboud University Medical Center, Nijmegen, Netherlands., Dibbets AC; Division of Pharmacology and Toxicology, Department of Pharmacy, Radboud University Medical Center, Nijmegen, Netherlands.; Department of Obstetrics and Gynaecology, Maastricht University Medical Centre, Maastricht, Netherlands., Ceulemans M; Clinical Pharmacology and Pharmacotherapy, Department of Pharmaceutical and Pharmacological Sciences, KULeuven, Belgium.; IQ Health, Radboud University Medical Center, Nijmegen, Netherlands.; L-C&Y, KU Leuven Child and Youth Institute, Leuven, Belgium., de Vries LC; Teratology Information Service, Netherlands Pharmacovigilance Centre Lareb, S'Hertogenbosch, Netherlands., Franklin BD; Centre for Medication Safety and Service Quality, Imperial College Healthcare NHS Trust, London, United Kingdom.; Department of Practice and Policy, UCL School of Pharmacy, London, United Kingdom., Scheepers HCJ; Department of Obstetrics and Gynaecology, Maastricht University Medical Centre, Maastricht, Netherlands.; Grow, School for Oncology and Reproduction, Maastricht, Netherlands., de Wildt SN; Division of Pharmacology and Toxicology, Department of Pharmacy, Radboud University Medical Center, Nijmegen, Netherlands.; Department of Paediatric and Neonatal Intensive Care, Erasmus MC-Sophia Children's Hospital, Rotterdam, Netherlands.

Publikováno v: Frontiers in pharmacology [Front Pharmacol] 2024 Aug 15; Vol. 15, pp. 1403747. Date of Electronic Publication: 2024 Aug 15 (Print Publication: 2024).