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Self-restoration of cardiac excitation rhythm by anti-arrhythmic ion channel gating.

Autor: Majumder R; Laboratory of Experimental Cardiology, Department of Cardiology, Leiden University Medical Center, Leiden, Netherlands., De Coster T; Laboratory of Experimental Cardiology, Department of Cardiology, Leiden University Medical Center, Leiden, Netherlands.; Department of Physics and Astronomy, Ghent University, Ghent, Belgium.; Department of Cardiovascular Sciences, KU Leuven, Leuven, Belgium., Kudryashova N; Laboratory of Experimental Cardiology, Department of Cardiology, Leiden University Medical Center, Leiden, Netherlands.; Department of Physics and Astronomy, Ghent University, Ghent, Belgium., Verkerk AO; Department of Medical Biology, Amsterdam UMC, Amsterdam, Netherlands.; Department of Experimental Cardiology, Amsterdam UMC, Amsterdam, Netherlands., Kazbanov IV; Department of Physics and Astronomy, Ghent University, Ghent, Belgium., Ördög B; Laboratory of Experimental Cardiology, Department of Cardiology, Leiden University Medical Center, Leiden, Netherlands., Harlaar N; Laboratory of Experimental Cardiology, Department of Cardiology, Leiden University Medical Center, Leiden, Netherlands., Wilders R; Department of Medical Biology, Amsterdam UMC, Amsterdam, Netherlands., de Vries AA; Laboratory of Experimental Cardiology, Department of Cardiology, Leiden University Medical Center, Leiden, Netherlands., Ypey DL; Laboratory of Experimental Cardiology, Department of Cardiology, Leiden University Medical Center, Leiden, Netherlands., Panfilov AV; Laboratory of Experimental Cardiology, Department of Cardiology, Leiden University Medical Center, Leiden, Netherlands.; Department of Physics and Astronomy, Ghent University, Ghent, Belgium.; Laboratory of Computational Biology and Medicine, Ural Federal University, Ekaterinburg, Russian Federation., Pijnappels DA; Laboratory of Experimental Cardiology, Department of Cardiology, Leiden University Medical Center, Leiden, Netherlands.

Publikováno v: ELife [Elife] 2020 Jun 08; Vol. 9. Date of Electronic Publication: 2020 Jun 08.

Cardiomyogenic differentiation of human adipose-derived mesenchymal stem cells transduced with Tbx20-encoding lentiviral vectors.

Autor: Neshati V; Biotechnology Research Center, Institute of Pharmaceutical Technology, Mashhad University of Medical Sciences, Mashhad, Iran., Mollazadeh S; Biotechnology Research Center, Institute of Pharmaceutical Technology, Mashhad University of Medical Sciences, Mashhad, Iran., Fazly Bazzaz BS; School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran., de Vries AA; Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands., Mojarrad M; Medical Genetics Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.; Department of Medical Genetics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran., Naderi-Meshkin H; Stem Cell and Regenerative Medicine Research Department, Iranian Academic Center for Education, Culture Research (ACECR), Mashhad Branch, Mashhad, Iran., Neshati Z; Department of Biology, Faculty of Sciences, Ferdowsi University of Mashhad, Mashhad, Iran., Kerachian MA; Medical Genetics Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.; Department of Medical Genetics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Publikováno v: Journal of cellular biochemistry [J Cell Biochem] 2018 Jul; Vol. 119 (7), pp. 6146-6153. Date of Electronic Publication: 2018 Apr 10.

TECRL, a new life-threatening inherited arrhythmia gene associated with overlapping clinical features of both LQTS and CPVT.

Autor: Devalla HD; Department of Anatomy & Embryology, Leiden University Medical Center, Leiden, The Netherlands h.d.devalla@lumc.nl john.david.rioux@umontreal.ca z.a.bhuiyan@chuv.ch r.passier@lumc.nl., Gélinas R; Montreal Heart Institute, Montreal, QC, Canada.; Department of Medicine, Université de Montréal, Montreal, QC, Canada., Aburawi EH; Department of Pediatrics, College of Medicine and Health Sciences, UAE University, Al Ain, United Arab Emirates., Beqqali A; Heart Failure Research Center, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands., Goyette P; Montreal Heart Institute, Montreal, QC, Canada., Freund C; Department of Anatomy & Embryology, Leiden University Medical Center, Leiden, The Netherlands.; Leiden University Medical Center hiPSC Core Facility, Leiden, The Netherlands., Chaix MA; Montreal Heart Institute, Montreal, QC, Canada.; Department of Medicine, Université de Montréal, Montreal, QC, Canada., Tadros R; Montreal Heart Institute, Montreal, QC, Canada.; Department of Medicine, Université de Montréal, Montreal, QC, Canada.; Heart Failure Research Center, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands., Jiang H; Beijing Genomics Institute, Shenzhen, China.; Shenzhen Key Laboratory of Genomics, Shenzhen, China.; The Guangdong Enterprise Key Laboratory of Human Disease Genomics, Shenzhen, China., Le Béchec A; Vital-IT group, Swiss Institute of Bioinformatics, Lausanne, Switzerland., Monshouwer-Kloots JJ; Department of Anatomy & Embryology, Leiden University Medical Center, Leiden, The Netherlands., Zwetsloot T; Department of Anatomy & Embryology, Leiden University Medical Center, Leiden, The Netherlands., Kosmidis G; Department of Anatomy & Embryology, Leiden University Medical Center, Leiden, The Netherlands., Latour F; Montreal Heart Institute, Montreal, QC, Canada., Alikashani A; Montreal Heart Institute, Montreal, QC, Canada., Hoekstra M; Heart Failure Research Center, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands., Schlaepfer J; Service de Cardiologie, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland., Mummery CL; Department of Anatomy & Embryology, Leiden University Medical Center, Leiden, The Netherlands., Stevenson B; Vital-IT group, Swiss Institute of Bioinformatics, Lausanne, Switzerland., Kutalik Z; Vital-IT group, Swiss Institute of Bioinformatics, Lausanne, Switzerland.; Institute of Social and Preventive Medicine, University Hospital (CHUV) and University of Lausanne, Lausanne, Switzerland., de Vries AA; Laboratory of Experimental Cardiology, Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.; ICIN-Netherlands Heart Institute, Utrecht, The Netherlands., Rivard L; Montreal Heart Institute, Montreal, QC, Canada.; Department of Medicine, Université de Montréal, Montreal, QC, Canada., Wilde AA; Heart Center, Department of Clinical and Experimental Cardiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.; Princess Al-Jawhara Al-Brahim Centre of Excellence in Research of Hereditary Disorders, Jeddah, Saudi Arabia., Talajic M; Montreal Heart Institute, Montreal, QC, Canada.; Department of Medicine, Université de Montréal, Montreal, QC, Canada., Verkerk AO; Heart Failure Research Center, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands., Al-Gazali L; Department of Pediatrics, College of Medicine and Health Sciences, UAE University, Al Ain, United Arab Emirates., Rioux JD; Montreal Heart Institute, Montreal, QC, Canada h.d.devalla@lumc.nl john.david.rioux@umontreal.ca z.a.bhuiyan@chuv.ch r.passier@lumc.nl.; Department of Medicine, Université de Montréal, Montreal, QC, Canada., Bhuiyan ZA; Laboratoire Génétiqué Moléculaire, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland h.d.devalla@lumc.nl john.david.rioux@umontreal.ca z.a.bhuiyan@chuv.ch r.passier@lumc.nl., Passier R; Department of Anatomy & Embryology, Leiden University Medical Center, Leiden, The Netherlands h.d.devalla@lumc.nl john.david.rioux@umontreal.ca z.a.bhuiyan@chuv.ch r.passier@lumc.nl.; Department of Applied Stem Cell Technologies, MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, Enschede, The Netherlands.

Publikováno v: EMBO molecular medicine [EMBO Mol Med] 2016 Dec 01; Vol. 8 (12), pp. 1390-1408. Date of Electronic Publication: 2016 Dec 01 (Print Publication: 2016).

Allosteric Modulation of Kv11.1 (hERG) Channels Protects Against Drug-Induced Ventricular Arrhythmias.

Autor: Yu Z; From the Division of Medicinal Chemistry, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands (Z.Y., J.P.D.v.V., A.P.I., L.H.H.); Laboratory of Experimental Cardiology, Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands (J.L., M.J.S., D.A.P., A.A.F.d.V.); and ICIN-Netherlands Heart Institute, Utrecht, The Netherlands (J.L., A.A.F.d.V.)., Liu J; From the Division of Medicinal Chemistry, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands (Z.Y., J.P.D.v.V., A.P.I., L.H.H.); Laboratory of Experimental Cardiology, Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands (J.L., M.J.S., D.A.P., A.A.F.d.V.); and ICIN-Netherlands Heart Institute, Utrecht, The Netherlands (J.L., A.A.F.d.V.)., van Veldhoven JP; From the Division of Medicinal Chemistry, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands (Z.Y., J.P.D.v.V., A.P.I., L.H.H.); Laboratory of Experimental Cardiology, Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands (J.L., M.J.S., D.A.P., A.A.F.d.V.); and ICIN-Netherlands Heart Institute, Utrecht, The Netherlands (J.L., A.A.F.d.V.)., IJzerman AP; From the Division of Medicinal Chemistry, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands (Z.Y., J.P.D.v.V., A.P.I., L.H.H.); Laboratory of Experimental Cardiology, Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands (J.L., M.J.S., D.A.P., A.A.F.d.V.); and ICIN-Netherlands Heart Institute, Utrecht, The Netherlands (J.L., A.A.F.d.V.)., Schalij MJ; From the Division of Medicinal Chemistry, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands (Z.Y., J.P.D.v.V., A.P.I., L.H.H.); Laboratory of Experimental Cardiology, Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands (J.L., M.J.S., D.A.P., A.A.F.d.V.); and ICIN-Netherlands Heart Institute, Utrecht, The Netherlands (J.L., A.A.F.d.V.)., Pijnappels DA; From the Division of Medicinal Chemistry, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands (Z.Y., J.P.D.v.V., A.P.I., L.H.H.); Laboratory of Experimental Cardiology, Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands (J.L., M.J.S., D.A.P., A.A.F.d.V.); and ICIN-Netherlands Heart Institute, Utrecht, The Netherlands (J.L., A.A.F.d.V.)., Heitman LH; From the Division of Medicinal Chemistry, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands (Z.Y., J.P.D.v.V., A.P.I., L.H.H.); Laboratory of Experimental Cardiology, Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands (J.L., M.J.S., D.A.P., A.A.F.d.V.); and ICIN-Netherlands Heart Institute, Utrecht, The Netherlands (J.L., A.A.F.d.V.). l.h.heitman@lacdr.leidenuniv.nl a.a.f.de_vries@lumc.nl., de Vries AA; From the Division of Medicinal Chemistry, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands (Z.Y., J.P.D.v.V., A.P.I., L.H.H.); Laboratory of Experimental Cardiology, Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands (J.L., M.J.S., D.A.P., A.A.F.d.V.); and ICIN-Netherlands Heart Institute, Utrecht, The Netherlands (J.L., A.A.F.d.V.). l.h.heitman@lacdr.leidenuniv.nl a.a.f.de_vries@lumc.nl.

Publikováno v: Circulation. Arrhythmia and electrophysiology [Circ Arrhythm Electrophysiol] 2016 Apr; Vol. 9 (4), pp. e003439.