Human monoclonal antibodies against Staphylococcus aureus surface antigens recognize in vitro biofilm and in vivo implant infections

Autor: Suzan H.M. Rooijakkers, Alexander R. Horswill, Jakub Kwiecinski, Ruud M. Ramakers, Marco C. Viveen, H. C. Vogely, van Strijp Ja, Gerard C. Krijger, Jeffrey S. Kavanaugh, E Boel, de Vor L, Frederik Beekman, Harrie Weinans, Marnix G.E.H. Lam, van der Wal Bc, Ad C. Fluit, van Dijk B, Ekaterina Dadachova, Piet C. Aerts, de Haas Cj, van Kessel Kp

Implant-associated Staphylococcus aureus infections are difficult to treat because of biofilm formation. Bacteria in a biofilm are often insensitive to antibiotics and host immunity. Monoclonal antibodies (mAbs) could provide an alternative approach

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https://doi.org/10.1101/2021.02.09.429966

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Single-cell Sequencing of Circulating Human Plasmablasts during Staphylococcus aureus Bacteremia.

Autor: Kerkman PF; Department of Medical Microbiology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., de Vor L; Department of Medical Microbiology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., van der Vaart TW; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.; Amsterdam Institute for Infection and Immunity, Infectious Diseases, Amsterdam, the Netherlands., Ten Doesschate T; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.; Department of Internal Medicine, Jeroen Bosch Hospital, Den Bosch, the Netherlands., Muts RM; Department of Medical Microbiology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Depelteau JS; Department of Medical Microbiology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Scheepmaker LM; Department of Medical Microbiology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Ruyken M; Department of Medical Microbiology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., de Haas CJC; Department of Medical Microbiology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Aerts PC; Department of Medical Microbiology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Marijnissen RJ; Genmab, Utrecht, the Netherlands., Schuurman J; Genmab, Utrecht, the Netherlands., Beurskens FJ; Genmab, Utrecht, the Netherlands., Gorlani A; Genmab, Utrecht, the Netherlands., Bardoel BW; Department of Medical Microbiology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Rooijakkers SHM; Department of Medical Microbiology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.

Publikováno v: Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2024 Oct 25. Date of Electronic Publication: 2024 Oct 25.