Spermidine is essential for fasting-mediated autophagy and longevity.

Autor: Hofer SJ; Institute of Molecular Biosciences, NAWI Graz, University of Graz, Graz, Austria.; Field of Excellence BioHealth, University of Graz, Graz, Austria.; BioTechMed Graz, Graz, Austria.; Centre de Recherche des Cordeliers, Équipe Labellisée par la Ligue Contre le Cancer, Université de Paris Cité, Sorbonne Université, Inserm U1138, Institut Universitaire de France, Paris, France.; Metabolomics and Cell Biology Platforms, Gustave Roussy Cancer Center, Université Paris Saclay, Villejuif, France., Daskalaki I; Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology - Hellas, Heraklion, Greece.; Department of Biology, School of Sciences and Engineering, University of Crete, Heraklion, Greece., Bergmann M; Institute of Molecular Biosciences, NAWI Graz, University of Graz, Graz, Austria., Friščić J; Department of Dermatology, Allergy and Venerology, University of Lübeck, Lübeck, Germany.; Institute for Systemic Inflammation Research, University of Lübeck, Lübeck, Germany., Zimmermann A; Institute of Molecular Biosciences, NAWI Graz, University of Graz, Graz, Austria.; Field of Excellence BioHealth, University of Graz, Graz, Austria.; BioTechMed Graz, Graz, Austria., Mueller MI; Institute of Molecular Biosciences, NAWI Graz, University of Graz, Graz, Austria., Abdellatif M; BioTechMed Graz, Graz, Austria.; Centre de Recherche des Cordeliers, Équipe Labellisée par la Ligue Contre le Cancer, Université de Paris Cité, Sorbonne Université, Inserm U1138, Institut Universitaire de France, Paris, France.; Metabolomics and Cell Biology Platforms, Gustave Roussy Cancer Center, Université Paris Saclay, Villejuif, France.; Division of Cardiology, Medical University of Graz, Graz, Austria., Nicastro R; Department of Biology, University of Fribourg, Fribourg, Switzerland., Masser S; BioTechMed Graz, Graz, Austria.; Institute of Pharmaceutical Sciences, Pharmaceutical Chemistry, University of Graz, Graz, Austria., Durand S; Centre de Recherche des Cordeliers, Équipe Labellisée par la Ligue Contre le Cancer, Université de Paris Cité, Sorbonne Université, Inserm U1138, Institut Universitaire de France, Paris, France.; Metabolomics and Cell Biology Platforms, Gustave Roussy Cancer Center, Université Paris Saclay, Villejuif, France., Nartey A; Institute of Molecular Biosciences, NAWI Graz, University of Graz, Graz, Austria., Waltenstorfer M; Institute of Molecular Biosciences, NAWI Graz, University of Graz, Graz, Austria., Enzenhofer S; Institute of Molecular Biosciences, NAWI Graz, University of Graz, Graz, Austria., Faimann I; Institute of Molecular Biosciences, NAWI Graz, University of Graz, Graz, Austria., Gschiel V; Institute of Molecular Biosciences, NAWI Graz, University of Graz, Graz, Austria., Bajaj T; Neurohomeostasis Research Group, Department of Psychiatry and Psychotherapy, University Hospital Bonn, Bonn, Germany., Niemeyer C; Neurohomeostasis Research Group, Department of Psychiatry and Psychotherapy, University Hospital Bonn, Bonn, Germany., Gkikas I; Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology - Hellas, Heraklion, Greece.; Department of Biology, School of Sciences and Engineering, University of Crete, Heraklion, Greece., Pein L; Institute of Molecular Biosciences, NAWI Graz, University of Graz, Graz, Austria., Cerrato G; Centre de Recherche des Cordeliers, Équipe Labellisée par la Ligue Contre le Cancer, Université de Paris Cité, Sorbonne Université, Inserm U1138, Institut Universitaire de France, Paris, France.; Metabolomics and Cell Biology Platforms, Gustave Roussy Cancer Center, Université Paris Saclay, Villejuif, France., Pan H; Centre de Recherche des Cordeliers, Équipe Labellisée par la Ligue Contre le Cancer, Université de Paris Cité, Sorbonne Université, Inserm U1138, Institut Universitaire de France, Paris, France.; Metabolomics and Cell Biology Platforms, Gustave Roussy Cancer Center, Université Paris Saclay, Villejuif, France., Liang Y; Institute for Biology and Genetics, Freie Universität Berlin, Berlin, Germany.; Cluster of Excellence, NeuroCure, Berlin, Germany., Tadic J; Institute of Molecular Biosciences, NAWI Graz, University of Graz, Graz, Austria.; Field of Excellence BioHealth, University of Graz, Graz, Austria.; BioTechMed Graz, Graz, Austria., Jerkovic A; Institute of Molecular Biosciences, NAWI Graz, University of Graz, Graz, Austria., Aprahamian F; Centre de Recherche des Cordeliers, Équipe Labellisée par la Ligue Contre le Cancer, Université de Paris Cité, Sorbonne Université, Inserm U1138, Institut Universitaire de France, Paris, France.; Metabolomics and Cell Biology Platforms, Gustave Roussy Cancer Center, Université Paris Saclay, Villejuif, France., Robbins CE; Department of Biochemistry and Molecular Biology, University of New Mexico Health Sciences Center, Albuquerque, NM, USA., Nirmalathasan N; Centre de Recherche des Cordeliers, Équipe Labellisée par la Ligue Contre le Cancer, Université de Paris Cité, Sorbonne Université, Inserm U1138, Institut Universitaire de France, Paris, France.; Metabolomics and Cell Biology Platforms, Gustave Roussy Cancer Center, Université Paris Saclay, Villejuif, France., Habisch H; Research Unit Integrative Structural Biology, Otto Loewi Research Center, Medicinal Chemistry, Medical University of Graz, Graz, Austria., Annerer E; Institute of Pharmaceutical Sciences, Pharmaceutical Chemistry, University of Graz, Graz, Austria., Dethloff F; Max Planck Institute for Biology of Ageing, Cologne, Germany., Stumpe M; Department of Biology, University of Fribourg, Fribourg, Switzerland., Grundler F; Buchinger Wilhelmi Clinic, Überlingen, Germany., Wilhelmi de Toledo F; Buchinger Wilhelmi Clinic, Überlingen, Germany., Heinz DE; Neurohomeostasis Research Group, Department of Psychiatry and Psychotherapy, University Hospital Bonn, Bonn, Germany., Koppold DA; Institute of Social Medicine, Epidemiology and Health Economics, corporate member of Freie Universität Berlin and Humboldt-Universität, Charité-Universitätsmedizin, Berlin, Germany.; Department of Pediatrics, Division of Oncology and Hematology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.; Department of Internal Medicine and Nature-based Therapies, Immanuel Hospital Berlin, Berlin, Germany., Rajput Khokhar A; Institute of Social Medicine, Epidemiology and Health Economics, corporate member of Freie Universität Berlin and Humboldt-Universität, Charité-Universitätsmedizin, Berlin, Germany.; Department of Dermatology, Venereology and Allergology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany., Michalsen A; Institute of Social Medicine, Epidemiology and Health Economics, corporate member of Freie Universität Berlin and Humboldt-Universität, Charité-Universitätsmedizin, Berlin, Germany.; Department of Internal Medicine and Nature-based Therapies, Immanuel Hospital Berlin, Berlin, Germany., Tripolt NJ; Interdisciplinary Metabolic Medicine Trials Unit, Division of Endocrinology and Diabetology, Medical University of Graz, Graz, Austria.; Division of Endocrinology and Diabetology, Department of Internal Medicine, Medical University of Graz, Graz, Austria., Sourij H; Interdisciplinary Metabolic Medicine Trials Unit, Division of Endocrinology and Diabetology, Medical University of Graz, Graz, Austria.; Division of Endocrinology and Diabetology, Department of Internal Medicine, Medical University of Graz, Graz, Austria., Pieber TR; BioTechMed Graz, Graz, Austria.; Interdisciplinary Metabolic Medicine Trials Unit, Division of Endocrinology and Diabetology, Medical University of Graz, Graz, Austria.; Division of Endocrinology and Diabetology, Department of Internal Medicine, Medical University of Graz, Graz, Austria.; HEALTH - Institute for Biomedical Research and Technologies, Joanneum Research Forschungsgesellschaft, Graz, Austria., de Cabo R; Experimental Gerontology Section, Translational Gerontology Branch, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA., McCormick MA; Department of Biochemistry and Molecular Biology, University of New Mexico Health Sciences Center, Albuquerque, NM, USA., Magnes C; HEALTH - Institute for Biomedical Research and Technologies, Joanneum Research Forschungsgesellschaft, Graz, Austria., Kepp O; Centre de Recherche des Cordeliers, Équipe Labellisée par la Ligue Contre le Cancer, Université de Paris Cité, Sorbonne Université, Inserm U1138, Institut Universitaire de France, Paris, France.; Metabolomics and Cell Biology Platforms, Gustave Roussy Cancer Center, Université Paris Saclay, Villejuif, France., Dengjel J; Department of Biology, University of Fribourg, Fribourg, Switzerland., Sigrist SJ; Institute for Biology and Genetics, Freie Universität Berlin, Berlin, Germany.; Cluster of Excellence, NeuroCure, Berlin, Germany., Gassen NC; Neurohomeostasis Research Group, Department of Psychiatry and Psychotherapy, University Hospital Bonn, Bonn, Germany., Sedej S; BioTechMed Graz, Graz, Austria.; Division of Cardiology, Medical University of Graz, Graz, Austria.; Institute of Physiology, Faculty of Medicine, University of Maribor, Maribor, Slovenia., Madl T; BioTechMed Graz, Graz, Austria.; Research Unit Integrative Structural Biology, Otto Loewi Research Center, Medicinal Chemistry, Medical University of Graz, Graz, Austria., De Virgilio C; Department of Biology, University of Fribourg, Fribourg, Switzerland., Stelzl U; Field of Excellence BioHealth, University of Graz, Graz, Austria.; BioTechMed Graz, Graz, Austria.; Institute of Pharmaceutical Sciences, Pharmaceutical Chemistry, University of Graz, Graz, Austria., Hoffmann MH; Department of Dermatology, Allergy and Venerology, University of Lübeck, Lübeck, Germany.; Institute for Systemic Inflammation Research, University of Lübeck, Lübeck, Germany., Eisenberg T; Institute of Molecular Biosciences, NAWI Graz, University of Graz, Graz, Austria.; Field of Excellence BioHealth, University of Graz, Graz, Austria.; BioTechMed Graz, Graz, Austria., Tavernarakis N; Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology - Hellas, Heraklion, Greece. tavernarakis@imbb.forth.gr.; Division of Basic Sciences, School of Medicine, University of Crete, Heraklion, Greece. tavernarakis@imbb.forth.gr., Kroemer G; Centre de Recherche des Cordeliers, Équipe Labellisée par la Ligue Contre le Cancer, Université de Paris Cité, Sorbonne Université, Inserm U1138, Institut Universitaire de France, Paris, France. kroemer@orange.fr.; Metabolomics and Cell Biology Platforms, Gustave Roussy Cancer Center, Université Paris Saclay, Villejuif, France. kroemer@orange.fr.; Institut du Cancer Paris CARPEM, Department of Biology, Hôpital Européen Georges Pompidou, AP-HP, Paris, France. kroemer@orange.fr., Madeo F; Institute of Molecular Biosciences, NAWI Graz, University of Graz, Graz, Austria. frank.madeo@uni-graz.at.; Field of Excellence BioHealth, University of Graz, Graz, Austria. frank.madeo@uni-graz.at.; BioTechMed Graz, Graz, Austria. frank.madeo@uni-graz.at.

Publikováno v: Nature cell biology [Nat Cell Biol] 2024 Sep; Vol. 26 (9), pp. 1571-1584. Date of Electronic Publication: 2024 Aug 08.

HDL cholesterol efflux capacity and cholesterol loading capacity in long-term fasting: Evidence from a prospective, single-arm interventional study in healthy individuals.

Autor: Grundler F; Buchinger Wilhelmi Clinic, Wilhelm-Beck-Straße 27, 88662, Überlingen, Germany. Electronic address: franziska.grundler@buchinger-wilhelmi.com., Palumbo M; Department of Food and Drug, University of Parma, Parma, Italy., Adorni MP; Department of Medicine and Surgery, Unit of Neuroscience, University of Parma, Parma, Italy., Zimetti F; Department of Food and Drug, University of Parma, Parma, Italy., Papotti B; Department of Food and Drug, University of Parma, Parma, Italy., Plonné D; MVZ Humangenetik Ulm, Karlstraße 31-33, 89073, Ulm, Germany., Holley A; Buchinger Wilhelmi Clinic, Wilhelm-Beck-Straße 27, 88662, Überlingen, Germany., Mesnage R; Buchinger Wilhelmi Clinic, Wilhelm-Beck-Straße 27, 88662, Überlingen, Germany; Department of Nutritional Sciences, School of Life Course Sciences, Faculty of Life Sciences and Medicine, King's College London, SE1 9NH, London, UK., Ruscica M; Department of Pharmacological and Biomolecular Sciences 'Rodolfo Paoletti', Università degli Studi di Milano, Milan, Italy; Department of Cardio-Thoracic-Vascular Diseases, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy. Electronic address: massimiliano.ruscica@unimi.it., Wilhelmi de Toledo F; Buchinger Wilhelmi Clinic, Wilhelm-Beck-Straße 27, 88662, Überlingen, Germany.

Publikováno v: Atherosclerosis [Atherosclerosis] 2024 Oct; Vol. 397, pp. 118548. Date of Electronic Publication: 2024 Aug 06.

Long-Term Fasting-Induced Ketosis in 1610 Subjects: Metabolic Regulation and Safety.

Autor: Grundler F; Buchinger Wilhelmi Clinic, Wilhelmi-Beck-Straße 27, 88662 Überlingen, Germany., Mesnage R; Buchinger Wilhelmi Clinic, Wilhelmi-Beck-Straße 27, 88662 Überlingen, Germany.; Gene Expression and Therapy Group, King's College London, Faculty of Life Sciences & Medicine, Department of Medical and Molecular Genetics, 8th Floor, Tower Wing, Guy's Hospital, Great Maze Pond, London SE1 9RT, UK., Ruppert PMM; Department for Biochemistry and Molecular Biology (BMB), University of Southern Denmark, 5230 Odense, Denmark., Kouretas D; Department of Biochemistry-Biotechnology, School of Health Sciences, University of Thessaly, 41500 Larissa, Greece., Wilhelmi de Toledo F; Buchinger Wilhelmi Clinic, Wilhelmi-Beck-Straße 27, 88662 Überlingen, Germany.

Publikováno v: Nutrients [Nutrients] 2024 Jun 13; Vol. 16 (12). Date of Electronic Publication: 2024 Jun 13.

The new facility for neutron tomography of IPEN-CNEN/SP and its potential to investigate hydrogenous substances

Autor: Schoueri, R.M., Domienikan, C., de Toledo, F., Andrade, M.L.G., Stanojev Pereira, M.A., Pugliesi, R.

Publikováno v: In Applied Radiation and Isotopes February 2014 84:22-26

Remodelling of the intestinal ecosystem during caloric restriction and fasting.

Autor: Ducarmon QR; Structural and Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany., Grundler F; Buchinger Wilhelmi Clinic, Wilhelmi-Beck-Straße 27, 88662 Überlingen, Germany., Le Maho Y; University of Strasbourg, CNRS, IPHC UMR, 7178, Strasbourg, France; Centre Scientifique de Monaco, Monaco, Monaco., Wilhelmi de Toledo F; Buchinger Wilhelmi Clinic, Wilhelmi-Beck-Straße 27, 88662 Überlingen, Germany., Zeller G; Structural and Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany. Electronic address: zeller@embl.de., Habold C; University of Strasbourg, CNRS, IPHC UMR, 7178, Strasbourg, France. Electronic address: caroline.habold@iphc.cnrs.fr., Mesnage R; Buchinger Wilhelmi Clinic, Wilhelmi-Beck-Straße 27, 88662 Überlingen, Germany; King's College London, Department of Medical and Molecular Genetics, London, UK. Electronic address: robin.mesnage@buchinger-wilhelmi.com.

Publikováno v: Trends in microbiology [Trends Microbiol] 2023 Aug; Vol. 31 (8), pp. 832-844. Date of Electronic Publication: 2023 Apr 06.