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The C-terminal αO helix of human Ogg1 is essential for 8-oxoguanine DNA glycosylase activity: the mitochondrial β-Ogg1 lacks this domain and does not have glycosylase activity.

Autor: Hashiguchi, K., Stuart, J. A., de Souza-Pinto, N. C., Bohr, V. A.

Publikováno v: Nucleic Acids Research; Oct2004, Vol. 32 Issue 18, p5596-5608, 13p

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The human Werner syndrome protein stimulates repair of oxidative DNA base damage by the DNA glycosylase NEIL1.

Autor: Das A; Department of Biochemistry and Molecular Biology and Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas 77555, USA., Boldogh I, Lee JW, Harrigan JA, Hegde ML, Piotrowski J, de Souza Pinto N, Ramos W, Greenberg MM, Hazra TK, Mitra S, Bohr VA

Publikováno v: The Journal of biological chemistry [J Biol Chem] 2007 Sep 07; Vol. 282 (36), pp. 26591-602. Date of Electronic Publication: 2007 Jul 03.

The C-terminal alphaO helix of human Ogg1 is essential for 8-oxoguanine DNA glycosylase activity: the mitochondrial beta-Ogg1 lacks this domain and does not have glycosylase activity.

Autor: Hashiguchi K; Laboratory of Molecular Gerontology, National Institute of Aging-IRP, National Institutes of Health, Box1, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA., Stuart JA, de Souza-Pinto NC, Bohr VA

Publikováno v: Nucleic acids research [Nucleic Acids Res] 2004 Oct 19; Vol. 32 (18), pp. 5596-608. Date of Electronic Publication: 2004 Oct 19 (Print Publication: 2004).