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Safety and efficacy of mitapivat in sickle cell disease (RISE UP): results from the phase 2 portion of a global, double-blind, randomised, placebo-controlled trial.

Autor: Idowu M; McGovern Medical School, UTHealth, Houston, TX, USA. Electronic address: modupe.idowu@uth.tmc.edu., Otieno L; Victoria Biomedical Research Institute, Kisumu, Kenya., Dumitriu B; Mid-Atlantic Permanente Medical Group, Largo, MD, USA., Lobo CLC; Research Division, HEMORIO, Rio de Janeiro, Brazil., Thein SL; Sickle Cell Branch, The National Heart, Lung, and Blood Institute, Bethesda, MD, USA., Andemariam B; New England Sickle Cell Institute, UConn Health, Farmington, CT, USA., Nnodu OE; Centre of Excellence for Sickle Cell Disease Research and Training, Department of Haematology and Blood Transfusion, College of Health Sciences, University of Abuja, Abuja, Nigeria., Inati A; LAU Gilbert and Rose-Marie Chaghoury School of Medicine, Byblos and NINI Hospital, Tripoli, Lebanon., Glaros AK; Central Michigan University, Children's Hospital of Michigan, Detroit, MI, USA., Bartolucci P; Univ Paris Est Créteil, Hôpitaux Universitaires Henri Mondor, APHP, Sickle Cell and Red Cell Disorders Referral Center-UMGGR, Créteil, France; IMRB Laboratory of Excellence LABEX Grex, Créteil, France; Clinical Investigation Center 1430, Créteil, France., Colombatti R; Pediatric Hematology Oncology Unit, University of Padova, Padova, Italy., Taher AT; American University of Beirut Medical Center, Beirut, Lebanon., Abboud MR; American University of Beirut Medical Center, Beirut, Lebanon., Darbari D; Children's National Hospital, Washington, DC, USA., Ataga KI; Center for Sickle Cell Disease, University of Tennessee Health Science Center, Memphis, TN, USA., Antmen AB; Acıbadem Adana Hospital, Pediatric Hematology and Stem Cell Transplantation Unit, Adana, Turkey., Kuo KHM; Division of Haematology, University of Toronto, Toronto, ON, Canada., de Souza Medina S; Hematology and Transfusion Medicine Center University of Campinas, Campinas, Brazil., Oluyadi A; Agios Pharmaceuticals, Cambridge, MA, USA., Iyer V; Fog Pharmaceuticals, Cambridge, MA, USA., Morris S; Agios Pharmaceuticals, Cambridge, MA, USA., Yates AM; Agios Pharmaceuticals, Cambridge, MA, USA., Shao H; Agios Pharmaceuticals, Cambridge, MA, USA., Patil S; Agios Pharmaceuticals, Cambridge, MA, USA., Urbstonaitis R; Agios Pharmaceuticals, Cambridge, MA, USA., Zaidi AU; Agios Pharmaceuticals, Cambridge, MA, USA., Gheuens S; Agios Pharmaceuticals, Cambridge, MA, USA., Smith WR; Virginia Commonwealth University, Richmond, VA, USA.

Publikováno v: The Lancet. Haematology [Lancet Haematol] 2024 Dec 04. Date of Electronic Publication: 2024 Dec 04.

Low SARS-CoV-2 seroprevalence in a cohort of Brazilian sickle cell disease patients: Possible effects of emphasis on social isolation for a population initially considered to be at very high risk.

Autor: Trafane LF; Hematology and Transfusion Medicine Center University of Campinas Campinas Brazil., da Costa VA; Hematology and Transfusion Medicine Center University of Campinas Campinas Brazil., da Silva Santos Duarte A; Hematology and Transfusion Medicine Center University of Campinas Campinas Brazil., Zangirolami AB; Hematology and Transfusion Medicine Center University of Campinas Campinas Brazil., Proenca-Modena JL; Laboratory of Emerging Viruses (LEVE), Department of Genetics, Evolution, Microbiology and Immunology, Institute of Biology University of Campinas Campinas Brazil., de Melo Campos P; Hematology and Transfusion Medicine Center University of Campinas Campinas Brazil., de Souza Medina S; Hematology and Transfusion Medicine Center University of Campinas Campinas Brazil., Saad STO; Hematology and Transfusion Medicine Center University of Campinas Campinas Brazil., Addas-Carvalho M; Hematology and Transfusion Medicine Center University of Campinas Campinas Brazil., Benites BD; Hematology and Transfusion Medicine Center University of Campinas Campinas Brazil.

Publikováno v: EJHaem [EJHaem] 2021 Jun 17; Vol. 2 (3), pp. 478-482. Date of Electronic Publication: 2021 Jun 17 (Print Publication: 2021).