Mebendazole targets essential proteins in glucose metabolism leading gastric cancer cells to death.

Autor: da Silva EL; Laboratory of Pharmacogenetics, Drug Research and Development Center (NPDM), Federal University of Ceará, Cel. Nunes de Melo, 1000 - Rodolfo Teófilo, Fortaleza, Brazil., Mesquita FP; Laboratory of Pharmacogenetics, Drug Research and Development Center (NPDM), Federal University of Ceará, Cel. Nunes de Melo, 1000 - Rodolfo Teófilo, Fortaleza, Brazil., Aragão DR; Laboratory of Pharmacogenetics, Drug Research and Development Center (NPDM), Federal University of Ceará, Cel. Nunes de Melo, 1000 - Rodolfo Teófilo, Fortaleza, Brazil., de Sousa Portilho AJ; Laboratory of Pharmacogenetics, Drug Research and Development Center (NPDM), Federal University of Ceará, Cel. Nunes de Melo, 1000 - Rodolfo Teófilo, Fortaleza, Brazil., Marinho AD; Laboratory of Pharmacogenetics, Drug Research and Development Center (NPDM), Federal University of Ceará, Cel. Nunes de Melo, 1000 - Rodolfo Teófilo, Fortaleza, Brazil., de Oliveira LLB; Laboratory of Pharmacogenetics, Drug Research and Development Center (NPDM), Federal University of Ceará, Cel. Nunes de Melo, 1000 - Rodolfo Teófilo, Fortaleza, Brazil., Lima LB; Laboratory of Pharmacogenetics, Drug Research and Development Center (NPDM), Federal University of Ceará, Cel. Nunes de Melo, 1000 - Rodolfo Teófilo, Fortaleza, Brazil., de Moraes MEA; Laboratory of Pharmacogenetics, Drug Research and Development Center (NPDM), Federal University of Ceará, Cel. Nunes de Melo, 1000 - Rodolfo Teófilo, Fortaleza, Brazil., Souza PFN; Laboratory of Pharmacogenetics, Drug Research and Development Center (NPDM), Federal University of Ceará, Cel. Nunes de Melo, 1000 - Rodolfo Teófilo, Fortaleza, Brazil; Department of Biochemistry and Molecular Biology, Federal University of Ceará, Mister Hull Avenue- Pici, Fortaleza, Brazil., Montenegro RC; Laboratory of Pharmacogenetics, Drug Research and Development Center (NPDM), Federal University of Ceará, Cel. Nunes de Melo, 1000 - Rodolfo Teófilo, Fortaleza, Brazil. Electronic address: rmontenegro@ufc.br.

Publikováno v: Toxicology and applied pharmacology [Toxicol Appl Pharmacol] 2023 Sep 15; Vol. 475, pp. 116630. Date of Electronic Publication: 2023 Jul 18.

Combined Therapy of ATRA and Imatinib Mesylate Decreases BCR-ABL and ABCB1/MDR1 Expression Through Cellular Differentiation in a Chronic Myeloid Leukemia Model.

Autor: Pinto CA; Human Cytogenetics Laboratory, Biological Science Institute, Federal University of Pará, Belém, Brazil., DE Sousa Portilho AJ; Pharmacogenetics Laboratory, Drug Research and Development Center (NPDM), Department of Physiology and Pharmacology, Federal University of Ceará, Fortaleza, Brazil., Barbosa MC; Faculty of Pharmacy, Federal University of Ceará, Fortaleza, Brazil., DE Moraes MEA; Pharmacogenetics Laboratory, Drug Research and Development Center (NPDM), Department of Physiology and Pharmacology, Federal University of Ceará, Fortaleza, Brazil., DE Lemos JAR; Biological Science Institute, Federal University of Pará, Belém, Brazil., Burbano RMR; Human Cytogenetics Laboratory, Biological Science Institute, Federal University of Pará, Belém, Brazil., Moreira-Nunes CA; Pharmacogenetics Laboratory, Drug Research and Development Center (NPDM), Department of Physiology and Pharmacology, Federal University of Ceará, Fortaleza, Brazil; carolfam@gmail.com.

Publikováno v: In vivo (Athens, Greece) [In Vivo] 2021 Sep-Oct; Vol. 35 (5), pp. 2661-2667.

Characterization of Telomerase ( hTERT ) in Solid and Hematopoietic Cancer Cell Lines Reveals Different Expression Patterns.

Autor: DE Holanda LS; Unichristus University Center, Faculty of Biomedicine, Fortaleza, Brazil., Mesquita FP; Pharmacogenetics Laboratory, Drug Research and Development Center (NPDM), Department of Physiology and Pharmacology, Federal University of Ceará, Fortaleza, Brazil., DE Moraes-Filho MO; Pharmacogenetics Laboratory, Drug Research and Development Center (NPDM), Department of Physiology and Pharmacology, Federal University of Ceará, Fortaleza, Brazil., DE Moraes MEA; Pharmacogenetics Laboratory, Drug Research and Development Center (NPDM), Department of Physiology and Pharmacology, Federal University of Ceará, Fortaleza, Brazil., Montenegro RC; Pharmacogenetics Laboratory, Drug Research and Development Center (NPDM), Department of Physiology and Pharmacology, Federal University of Ceará, Fortaleza, Brazil., DE Sousa Portilho AJ; Pharmacogenetics Laboratory, Drug Research and Development Center (NPDM), Department of Physiology and Pharmacology, Federal University of Ceará, Fortaleza, Brazil., Moreira-Nunes CA; Unichristus University Center, Faculty of Biomedicine, Fortaleza, Brazil carolfam@gmail.com.; Pharmacogenetics Laboratory, Drug Research and Development Center (NPDM), Department of Physiology and Pharmacology, Federal University of Ceará, Fortaleza, Brazil.

Publikováno v: Anticancer research [Anticancer Res] 2019 Sep; Vol. 39 (9), pp. 4743-4748.

Small benzothiazole molecule induces apoptosis and prevents metastasis through DNA interaction and c-MYC gene supression in diffuse-type gastric adenocarcinoma cell line.

Autor: Mesquita FP; Drug Research and Development Center (NPDM), Federal University of Ceará - Rua Cel, Nunes de Melo, n.1000 - Rodolfo Teófilo, Fortaleza, CE, Brazil; Biological Science Institute, Federal University of Pará - Rua Augusto Correa, n.01 - Guamá, Belem, Pará, Brazil., Pinto LC; Biological Science Institute, Federal University of Pará - Rua Augusto Correa, n.01 - Guamá, Belem, Pará, Brazil., Soares BM; Biological Science Institute, Federal University of Pará - Rua Augusto Correa, n.01 - Guamá, Belem, Pará, Brazil., de Sousa Portilho AJ; Drug Research and Development Center (NPDM), Federal University of Ceará - Rua Cel, Nunes de Melo, n.1000 - Rodolfo Teófilo, Fortaleza, CE, Brazil; Biological Science Institute, Federal University of Pará - Rua Augusto Correa, n.01 - Guamá, Belem, Pará, Brazil., da Silva EL; Biological Science Institute, Federal University of Pará - Rua Augusto Correa, n.01 - Guamá, Belem, Pará, Brazil., de Farias Ramos IN; Biological Science Institute, Federal University of Pará - Rua Augusto Correa, n.01 - Guamá, Belem, Pará, Brazil., Khayat AS; Biological Science Institute, Federal University of Pará - Rua Augusto Correa, n.01 - Guamá, Belem, Pará, Brazil., Moreira-Nunes CA; Drug Research and Development Center (NPDM), Federal University of Ceará - Rua Cel, Nunes de Melo, n.1000 - Rodolfo Teófilo, Fortaleza, CE, Brazil., Bezerra MM; Drug Research and Development Center (NPDM), Federal University of Ceará - Rua Cel, Nunes de Melo, n.1000 - Rodolfo Teófilo, Fortaleza, CE, Brazil., de Lucas Chazin E; Organic Chemistry Department, Fluminense Federal University, Outeiro de São João Batista, s/n - Centro, Niterói, Rio de Janeiro, Brazil., Vasconcelos TRA; Organic Chemistry Department, Fluminense Federal University, Outeiro de São João Batista, s/n - Centro, Niterói, Rio de Janeiro, Brazil., Burbano RMR; Biological Science Institute, Federal University of Pará - Rua Augusto Correa, n.01 - Guamá, Belem, Pará, Brazil., de Moraes MEA; Drug Research and Development Center (NPDM), Federal University of Ceará - Rua Cel, Nunes de Melo, n.1000 - Rodolfo Teófilo, Fortaleza, CE, Brazil., Montenegro RC; Drug Research and Development Center (NPDM), Federal University of Ceará - Rua Cel, Nunes de Melo, n.1000 - Rodolfo Teófilo, Fortaleza, CE, Brazil; Biological Science Institute, Federal University of Pará - Rua Augusto Correa, n.01 - Guamá, Belem, Pará, Brazil. Electronic address: felipe_mesquita05@hotmail.com.

Publikováno v: Chemico-biological interactions [Chem Biol Interact] 2018 Oct 01; Vol. 294, pp. 118-127. Date of Electronic Publication: 2018 Aug 11.