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A loss-of-function mutation in human Oxidation Resistance 1 disrupts the spatial-temporal regulation of histone arginine methylation in neurodevelopment.

Autor: Lin X; Department of Microbiology, Oslo University Hospital and University of Oslo, Oslo, Norway.; Department of Biochemistry, Oslo University Hospital and University of Oslo, Oslo, Norway.; Department of Clinical and Molecular Medicine (IKOM), Norwegian University of Science and Technology (NTNU), 7491, Trondheim, Norway.; Centre for Embryology and Healthy Development, University of Oslo and Oslo University Hospital, 0373, Oslo, Norway., Wang W; Department of Clinical and Molecular Medicine (IKOM), Norwegian University of Science and Technology (NTNU), 7491, Trondheim, Norway., Yang M; Department of Microbiology, Oslo University Hospital and University of Oslo, Oslo, Norway.; Department of Biochemistry, Oslo University Hospital and University of Oslo, Oslo, Norway.; Centre for Embryology and Healthy Development, University of Oslo and Oslo University Hospital, 0373, Oslo, Norway.; Norwegian Centre for Stem Cell Research, Oslo University Hospital and University of Oslo, Oslo, Norway., Damseh N; Department of Pediatrics, Makassed Hospital and Al-Quds University, East Jerusalem, Palestine., de Sousa MML; Department of Clinical and Molecular Medicine (IKOM), Norwegian University of Science and Technology (NTNU), 7491, Trondheim, Norway., Jacob F; Department of Neuroscience and Mahoney Institute for Neurosciences, University of Pennsylvania, Philadelphia, PA, 19104, USA., Lång A; Department of Microbiology, Oslo University Hospital and University of Oslo, Oslo, Norway.; Department of Biochemistry, Oslo University Hospital and University of Oslo, Oslo, Norway., Kristiansen E; Department of Microbiology, Oslo University Hospital and University of Oslo, Oslo, Norway.; Centre for Embryology and Healthy Development, University of Oslo and Oslo University Hospital, 0373, Oslo, Norway., Pannone M; Department of Clinical and Molecular Medicine (IKOM), Norwegian University of Science and Technology (NTNU), 7491, Trondheim, Norway., Kissova M; Department of Clinical and Molecular Medicine (IKOM), Norwegian University of Science and Technology (NTNU), 7491, Trondheim, Norway., Almaas R; Department of Pediatric Research, Oslo University Hospital and University of Oslo, Oslo, Norway., Kuśnierczyk A; Department of Microbiology, Oslo University Hospital and University of Oslo, Oslo, Norway.; The Proteomics and Metabolomics Core Facility (PROMEC), Norwegian University of Science and Technology (NTNU), 7491, Trondheim, Norway., Siller R; Norwegian Centre for Stem Cell Research, Oslo University Hospital and University of Oslo, Oslo, Norway.; Department of Molecular Medicine, University of Oslo, Oslo, Norway., Shahrour M; Department of Pediatrics, Makassed Hospital and Al-Quds University, East Jerusalem, Palestine.; Department of Newborn and Developmental Paediatrics, Toronto, ON, Canada., Al-Ashhab M; Department of Pediatrics, Makassed Hospital and Al-Quds University, East Jerusalem, Palestine., Abu-Libdeh B; Department of Pediatrics, Makassed Hospital and Al-Quds University, East Jerusalem, Palestine., Tang W; Department of Clinical and Molecular Medicine (IKOM), Norwegian University of Science and Technology (NTNU), 7491, Trondheim, Norway., Slupphaug G; Department of Microbiology, Oslo University Hospital and University of Oslo, Oslo, Norway.; The Proteomics and Metabolomics Core Facility (PROMEC), Norwegian University of Science and Technology (NTNU), 7491, Trondheim, Norway., Elpeleg O; Department of Genetics, Hadassah University Hospital, Jerusalem, Israel., Bøe SO; Department of Microbiology, Oslo University Hospital and University of Oslo, Oslo, Norway.; Department of Biochemistry, Oslo University Hospital and University of Oslo, Oslo, Norway., Eide L; Department of Biochemistry, Oslo University Hospital and University of Oslo, Oslo, Norway., Sullivan GJ; Norwegian Centre for Stem Cell Research, Oslo University Hospital and University of Oslo, Oslo, Norway.; Department of Molecular Medicine, University of Oslo, Oslo, Norway.; Department of Immunology, Oslo University Hospital and University of Oslo, Oslo, Norway., Rinholm JE; Department of Microbiology, Oslo University Hospital and University of Oslo, Oslo, Norway.; The Proteomics and Metabolomics Core Facility (PROMEC), Norwegian University of Science and Technology (NTNU), 7491, Trondheim, Norway., Song H; Department of Neuroscience and Mahoney Institute for Neurosciences, University of Pennsylvania, Philadelphia, PA, 19104, USA., Ming GL; Department of Neuroscience and Mahoney Institute for Neurosciences, University of Pennsylvania, Philadelphia, PA, 19104, USA., van Loon B; Department of Clinical and Molecular Medicine (IKOM), Norwegian University of Science and Technology (NTNU), 7491, Trondheim, Norway., Edvardson S; Department of Genetics, Hadassah University Hospital, Jerusalem, Israel. SIMON@hadassah.org.il., Ye J; Department of Clinical and Molecular Medicine (IKOM), Norwegian University of Science and Technology (NTNU), 7491, Trondheim, Norway. jing.ye@ntnu.no., Bjørås M; Department of Microbiology, Oslo University Hospital and University of Oslo, Oslo, Norway. Magnar.Bjoras@ntnu.no.; Department of Biochemistry, Oslo University Hospital and University of Oslo, Oslo, Norway. Magnar.Bjoras@ntnu.no.; Department of Clinical and Molecular Medicine (IKOM), Norwegian University of Science and Technology (NTNU), 7491, Trondheim, Norway. Magnar.Bjoras@ntnu.no.; Centre for Embryology and Healthy Development, University of Oslo and Oslo University Hospital, 0373, Oslo, Norway. Magnar.Bjoras@ntnu.no.; Norwegian Centre for Stem Cell Research, Oslo University Hospital and University of Oslo, Oslo, Norway. Magnar.Bjoras@ntnu.no.

Publikováno v: Genome biology [Genome Biol] 2023 Sep 29; Vol. 24 (1), pp. 216. Date of Electronic Publication: 2023 Sep 29.

DNA Repair Mechanisms are Activated in Circulating Lymphocytes of Hospitalized Covid-19 Patients.

Autor: Olsen MB; Research Institute of Internal Medicine, Oslo University Hospital, Oslo, Norway.; Institute of Clinical Medicine, University of Oslo, Oslo, Norway., Huse C; Research Institute of Internal Medicine, Oslo University Hospital, Oslo, Norway.; Institute of Clinical Medicine, University of Oslo, Oslo, Norway., de Sousa MML; Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway.; Proteomics and Modomics Experimental Core Facility (PROMEC), NTNU, Trondheim, Norway., Murphy SL; Research Institute of Internal Medicine, Oslo University Hospital, Oslo, Norway.; Institute of Clinical Medicine, University of Oslo, Oslo, Norway., Sarno A; Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway.; Department of Fisheries and New Biomarine Industry, SINTEF Ocean, Trondheim, Norway., Obermann TS; Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway., Yang K; Research Institute of Internal Medicine, Oslo University Hospital, Oslo, Norway., Holter JC; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; Department of Microbiology, Oslo University Hospital and University of Oslo, Oslo, Norway., Jørgensen MJ; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; Department of Infectious Diseases, Oslo University Hospital, Oslo, Norway., Christensen EE; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; Department of Infectious Diseases, Oslo University Hospital, Oslo, Norway., Wang W; Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway., Ji P; Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway., Heggelund L; Department of Internal Medicine, Vestre Viken Hospital Trust, Drammen, Norway.; Department of Clinical Science, Faculty of Medicine, University of Bergen, Bergen, Norway., Hoel H; Research Institute of Internal Medicine, Oslo University Hospital, Oslo, Norway.; Department of Medicine, Lovisenberg Diaconal Hospital, Oslo, Norway., Dyrhol-Riise AM; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; Department of Infectious Diseases, Oslo University Hospital, Oslo, Norway., Gregersen I; Research Institute of Internal Medicine, Oslo University Hospital, Oslo, Norway., Aukrust P; Research Institute of Internal Medicine, Oslo University Hospital, Oslo, Norway.; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; Section of Clinical Immunology and Infectious Diseases, Oslo University Hospital, Oslo, Norway., Bjørås M; Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway.; Department of Microbiology, Oslo University Hospital and University of Oslo, Oslo, Norway., Halvorsen B; Research Institute of Internal Medicine, Oslo University Hospital, Oslo, Norway.; Institute of Clinical Medicine, University of Oslo, Oslo, Norway., Dahl TB; Division of Critical Care and Emergencies, Oslo University Hospital, Oslo, Norway.

Publikováno v: Journal of inflammation research [J Inflamm Res] 2022 Dec 07; Vol. 15, pp. 6629-6644. Date of Electronic Publication: 2022 Dec 07 (Print Publication: 2022).

Impact of Oxidative DNA Damage and the Role of DNA Glycosylases in Neurological Dysfunction.

Autor: de Sousa MML; Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, 7028 Trondheim, Norway., Ye J; Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, 7028 Trondheim, Norway., Luna L; Department of Microbiology, Oslo University Hospital, University of Oslo, Rikshospitalet, 0424 Oslo, Norway., Hildrestrand G; Department of Microbiology, Oslo University Hospital, University of Oslo, Rikshospitalet, 0424 Oslo, Norway., Bjørås K; Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, 7028 Trondheim, Norway., Scheffler K; Department of Neurology, St. Olavs Hospital, 7006 Trondheim, Norway.; Department of Laboratory Medicine, St. Olavs Hospital, 7006 Trondheim, Norway.; Department of Neuromedicine and Movement Science, Norwegian University of Science and Technology, 7491 Trondheim, Norway., Bjørås M; Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, 7028 Trondheim, Norway.; Department of Microbiology, Oslo University Hospital, University of Oslo, Rikshospitalet, 0424 Oslo, Norway.

Publikováno v: International journal of molecular sciences [Int J Mol Sci] 2021 Nov 29; Vol. 22 (23). Date of Electronic Publication: 2021 Nov 29.

Enhanced base excision repair capacity in carotid atherosclerosis may protect nuclear DNA but not mitochondrial DNA.

Autor: Skarpengland T; Research Institute of Internal Medicine, Oslo University Hospital Rikshospitalet, Norway; Institute of Clinical Medicine, University of Oslo, Oslo, Norway. Electronic address: Tonje.Skarpengland@rr-research.no., Dahl TB; Research Institute of Internal Medicine, Oslo University Hospital Rikshospitalet, Norway; Institute of Clinical Medicine, University of Oslo, Oslo, Norway., Skjelland M; Research Institute of Internal Medicine, Oslo University Hospital Rikshospitalet, Norway; Department of Neurology, Oslo University Hospital Rikshospitalet, Norway., Scheffler K; Department of Medical Biochemistry, Oslo University Hospital Rikshospitalet, Norway; Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway., de Sousa MML; Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway; PROMEC Core Facility for Proteomics and Metabolomics, Norwegian University of Science and Technology, Trondheim, Norway., Gregersen I; Research Institute of Internal Medicine, Oslo University Hospital Rikshospitalet, Norway; Institute of Clinical Medicine, University of Oslo, Oslo, Norway., Kuśnierczyk A; Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway; PROMEC Core Facility for Proteomics and Metabolomics, Norwegian University of Science and Technology, Trondheim, Norway., Sharma A; PROMEC Core Facility for Proteomics and Metabolomics, Norwegian University of Science and Technology, Trondheim, Norway., Slupphaug G; Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway; PROMEC Core Facility for Proteomics and Metabolomics, Norwegian University of Science and Technology, Trondheim, Norway., Eide L; Department of Medical Biochemistry, Oslo University Hospital Rikshospitalet, Norway; Institute of Clinical Medicine, University of Oslo, Oslo, Norway., Segers FM; Research Institute of Internal Medicine, Oslo University Hospital Rikshospitalet, Norway., Skagen KR; Department of Neurology, Oslo University Hospital Rikshospitalet, Norway., Dahl CP; Research Institute of Internal Medicine, Oslo University Hospital Rikshospitalet, Norway; Department of Cardiology, Oslo University Hospital Rikshospitalet, Norway; Center of Heart Failure Research, University of Oslo, Oslo, Norway., Russell D; Department of Neurology, Oslo University Hospital Rikshospitalet, Norway; Institute of Clinical Medicine, University of Oslo, Oslo, Norway., Folkersen L; Center for Biological Sequence Analysis, Technical University of Denmark, Copenhagen, Denmark., Krohg-Sørensen K; Department of Thoracic and Cardiovascular Surgery, Oslo University Hospital Rikshospitalet, Norway; Institute of Clinical Medicine, University of Oslo, Oslo, Norway., Holm S; Research Institute of Internal Medicine, Oslo University Hospital Rikshospitalet, Norway; Lillehammer Hospital for Rheumatic Diseases, Lillehammer, Norway., Bjørås M; Department of Microbiology, Oslo University Hospital Rikshospitalet, Norway; Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway., Aukrust P; Research Institute of Internal Medicine, Oslo University Hospital Rikshospitalet, Norway; Section of Clinical Immunology and Infectious Diseases, Oslo University Hospital Rikshospitalet, Norway; Institute of Clinical Medicine, University of Oslo, Oslo, Norway; K.G. Jebsen Inflammatory Research Center, University of Oslo, Oslo, Norway., Halvorsen B; Research Institute of Internal Medicine, Oslo University Hospital Rikshospitalet, Norway; Institute of Clinical Medicine, University of Oslo, Oslo, Norway; K.G. Jebsen Inflammatory Research Center, University of Oslo, Oslo, Norway.

Publikováno v: Free radical biology & medicine [Free Radic Biol Med] 2016 Aug; Vol. 97, pp. 386-397. Date of Electronic Publication: 2016 Jul 02.