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Type III interferons induce pyroptosis in gut epithelial cells and impair mucosal repair.

Autor: Jena KK; Division of Immunology, Harvard Medical School and Boston Children's Hospital, Boston, MA 02115, USA., Mambu J; Aix Marseille Université, CNRS, INSERM, Centre d'Immunologie de Marseille-Luminy (CIML), 13288 Marseille Cedex, France., Boehmer D; Division of Immunology, Harvard Medical School and Boston Children's Hospital, Boston, MA 02115, USA; Department of Medicine II, University Hospital, LMU Munich, 81377 Munich, Germany., Sposito B; Division of Immunology, Harvard Medical School and Boston Children's Hospital, Boston, MA 02115, USA., Millet V; Aix Marseille Université, CNRS, INSERM, Centre d'Immunologie de Marseille-Luminy (CIML), 13288 Marseille Cedex, France., de Sousa Casal J; Division of Gastroenterology, Harvard Medical School and Boston Children's Hospital, Boston, MA 02115, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Program in Immunology, Harvard Medical School, Boston, MA 02115, USA., Muendlein HI; Department of Immunology, Tufts University School of Medicine, Boston, MA 02111, USA., Spreafico R; Institute for Quantitative and Computational Biosciences, University of California, Los Angeles, CA, USA., Fenouil R; Aix Marseille Université, CNRS, INSERM, Centre d'Immunologie de Marseille-Luminy (CIML), 13288 Marseille Cedex, France., Spinelli L; Aix Marseille Université, CNRS, INSERM, Centre d'Immunologie de Marseille-Luminy (CIML), 13288 Marseille Cedex, France., Wurbel S; Aix Marseille Université, CNRS, INSERM, Centre d'Immunologie de Marseille-Luminy (CIML), 13288 Marseille Cedex, France., Riquier C; Aix Marseille Université, CNRS, INSERM, Centre d'Immunologie de Marseille-Luminy (CIML), 13288 Marseille Cedex, France., Galland F; Aix Marseille Université, CNRS, INSERM, Centre d'Immunologie de Marseille-Luminy (CIML), 13288 Marseille Cedex, France., Naquet P; Aix Marseille Université, CNRS, INSERM, Centre d'Immunologie de Marseille-Luminy (CIML), 13288 Marseille Cedex, France., Chasson L; Aix Marseille Université, CNRS, INSERM, Centre d'Immunologie de Marseille-Luminy (CIML), 13288 Marseille Cedex, France., Elkins M; Division of Immunology, Harvard Medical School and Boston Children's Hospital, Boston, MA 02115, USA., Mitsialis V; Division of Gastroenterology, Harvard Medical School and Boston Children's Hospital, Boston, MA 02115, USA., Ketelut-Carneiro N; Program in Innate Immunity, Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA 01655, USA., Gwilt KB; Division of Gastroenterology, Harvard Medical School and Boston Children's Hospital, Boston, MA 02115, USA., Thiagarajah JR; Division of Gastroenterology, Harvard Medical School and Boston Children's Hospital, Boston, MA 02115, USA., Ruan HB; Department of Integrative Biology and Physiology, Center for Immunology, University of Minnesota Medical School, Minneapolis, MN 55455, USA., Lin Z; State Key Laboratory of Pharmaceutical Biotechnology, Ministry of Education Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, National Resource Center for Mutant Mice of China, Nanjing Drum Tower Hospital, School of Medicine, Nanjing University, Nanjing 210061, China., Lien E; Program in Innate Immunity, Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA 01655, USA; Center for Molecular inflammation Research, Norwegian University of Science and Technology (NTNU), 7491 Trondheim, Norway., Shao F; National Institute of Biological Sciences, Beijing 102206, China., Chou J; Division of Immunology, Harvard Medical School and Boston Children's Hospital, Boston, MA 02115, USA., Poltorak A; Department of Immunology, Tufts University School of Medicine, Boston, MA 02111, USA., Ordovas-Montanes J; Division of Gastroenterology, Harvard Medical School and Boston Children's Hospital, Boston, MA 02115, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Program in Immunology, Harvard Medical School, Boston, MA 02115, USA., Fitzgerald KA; Program in Innate Immunity, Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA 01655, USA., Snapper SB; Division of Gastroenterology, Harvard Medical School and Boston Children's Hospital, Boston, MA 02115, USA., Broggi A; Aix Marseille Université, CNRS, INSERM, Centre d'Immunologie de Marseille-Luminy (CIML), 13288 Marseille Cedex, France. Electronic address: broggi@ciml.univ-mrs.fr., Zanoni I; Division of Immunology, Harvard Medical School and Boston Children's Hospital, Boston, MA 02115, USA; Division of Gastroenterology, Harvard Medical School and Boston Children's Hospital, Boston, MA 02115, USA; Program in Immunology, Harvard Medical School, Boston, MA 02115, USA. Electronic address: ivan.zanoni@childrens.harvard.edu.

Publikováno v: Cell [Cell] 2024 Oct 30. Date of Electronic Publication: 2024 Oct 30.