Thiazolyl-isatin derivatives: Synthesis, in silico studies, in vitro biological profile against breast cancer cells, mRNA expression, P-gp modulation, and interactions of Akt2 and VIM proteins.

Autor: Freitas LAB; Departamento de Ciências Farmacêuticas, Centro de Ciências da Saúde, Universidade Federal de Pernambuco, 50740-520, Recife, PE, Brazil., Sousa C; Pharmacological and Regulatory Sciences Group (PharmRegSci), Research Institute for Medicines (iMed.ULisboa), Faculdade de Farmácia da Universidade de Lisboa, Lisbon, Portugal., Lima BS; Pharmacological and Regulatory Sciences Group (PharmRegSci), Research Institute for Medicines (iMed.ULisboa), Faculdade de Farmácia da Universidade de Lisboa, Lisbon, Portugal., Duarte D; Global Health and Tropical Medicine, GHTM, Associate Laboratory in Translation and Innovation Towards Global Health, LA-REAL, Instituto de Higiene e Medicina Tropical, IHMT, Universidade NOVA de Lisboa, UNL, 1349-008, Lisboa, Portugal., Gomes PATM; Departamento de Ciências Farmacêuticas, Centro de Ciências da Saúde, Universidade Federal de Pernambuco, 50740-520, Recife, PE, Brazil., Ramos CGC; Departamento de Ciências Farmacêuticas, Centro de Ciências da Saúde, Universidade Federal de Pernambuco, 50740-520, Recife, PE, Brazil., Costa VCM; Núcleo de Pesquisa em Inovação Terapêutica Suely Galdino, Universidade Federal de Pernambuco, 50670-901, Recife, PE, Brazil., Pitta MGDR; Núcleo de Pesquisa em Inovação Terapêutica Suely Galdino, Universidade Federal de Pernambuco, 50670-901, Recife, PE, Brazil., Rêgo MJBM; Núcleo de Pesquisa em Inovação Terapêutica Suely Galdino, Universidade Federal de Pernambuco, 50670-901, Recife, PE, Brazil., de Simone CA; Departamento de Física e Informática, Instituto de Física de São Carlos, Universidade de São Paulo, 13560-970, São Carlos, SP, Brazil., Videira M; Pharmacological and Regulatory Sciences Group (PharmRegSci), Research Institute for Medicines (iMed.ULisboa), Faculdade de Farmácia da Universidade de Lisboa, Lisbon, Portugal., Leite ACL; Departamento de Ciências Farmacêuticas, Centro de Ciências da Saúde, Universidade Federal de Pernambuco, 50740-520, Recife, PE, Brazil. Electronic address: ana.lleite@ufpe.br.

Publikováno v: Chemico-biological interactions [Chem Biol Interact] 2024 May 01; Vol. 394, pp. 110954. Date of Electronic Publication: 2024 Mar 20.

Rhodium(III)-Catalyzed C-H/N-H Alkyne Annulation of Nonsymmetric 2-Aryl (Benz)imidazole Derivatives: Photophysical and Mechanistic Insights.

Autor: Dias GG; Department of Chemistry, Institute of Exact Sciences, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais 31270-901, Brazil., Paz ERS; Department of Chemistry, Institute of Exact Sciences, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais 31270-901, Brazil., Kadooca JY; Department of Chemistry, Institute of Exact Sciences, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais 31270-901, Brazil., Sabino AA; Department of Chemistry, Institute of Exact Sciences, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais 31270-901, Brazil., Cury LA; Department of Physics, Institute of Exact Sciences, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais 31270-901, Brazil., Torikai K; Department of Chemistry, Faculty and Graduate School of Science, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819-0395, Japan., de Simone CA; Institute of Physics, University of São Paulo, São Carlos, São Paulo 13560-160, Brazil., Fantuzzi F; Institute for Inorganic Chemistry, Julius-Maximilians-Universität Würzburg Am Hubland, 97074 Würzburg, Germany., da Silva Júnior EN; Department of Chemistry, Institute of Exact Sciences, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais 31270-901, Brazil.

Publikováno v: The Journal of organic chemistry [J Org Chem] 2021 Jan 01; Vol. 86 (1), pp. 264-278. Date of Electronic Publication: 2020 Dec 11.

Synthesis of quinone imine and sulphur-containing compounds with antitumor and trypanocidal activities: redox and biological implications.

Autor: Almeida RG; Institute of Exact Sciences , Department of Chemistry , Federal University of Minas Gerais , Belo Horizonte , 31270-901 , MG , Brazil . Email: eufranio@ufmg.br., Valença WO; Institute of Exact Sciences , Department of Chemistry , Federal University of Minas Gerais , Belo Horizonte , 31270-901 , MG , Brazil . Email: eufranio@ufmg.br.; Center for the Development of Chemical Technologies , State University of Mato Grosso do Sul , Naviraí , 79950-000 , MS , Brazil., Rosa LG; Institute of Exact Sciences , Department of Chemistry , Federal University of Minas Gerais , Belo Horizonte , 31270-901 , MG , Brazil . Email: eufranio@ufmg.br., de Simone CA; Department of Physics and Informatics , Institute of Physics , University of São Paulo , São Carlos , 13560-160 , SP , Brazil., de Castro SL; Oswaldo Cruz Institute , FIOCRUZ , Rio de Janeiro , 21045-900 , RJ , Brazil., Barbosa JMC; Oswaldo Cruz Institute , FIOCRUZ , Rio de Janeiro , 21045-900 , RJ , Brazil., Pinheiro DP; Department of Physiology and Pharmacology , Federal University of Ceará , Fortaleza , CE 60430-270 , Brazil., Paier CRK; Department of Physiology and Pharmacology , Federal University of Ceará , Fortaleza , CE 60430-270 , Brazil., de Carvalho GGC; Department of Physiology and Pharmacology , Federal University of Ceará , Fortaleza , CE 60430-270 , Brazil., Pessoa C; Department of Physiology and Pharmacology , Federal University of Ceará , Fortaleza , CE 60430-270 , Brazil., Goulart MOF; Institute of Chemistry and Biotechnology , Federal University of Alagoas , CEP 57072-970 , Maceió , AL , Brazil., Kharma A; Institute of Exact Sciences , Department of Chemistry , Federal University of Minas Gerais , Belo Horizonte , 31270-901 , MG , Brazil . Email: eufranio@ufmg.br.; Division of Bioorganic Chemistry , School of Pharmacy , University of Saarland , D-66123 Saarbruecken , Germany., da Silva Júnior EN; Institute of Exact Sciences , Department of Chemistry , Federal University of Minas Gerais , Belo Horizonte , 31270-901 , MG , Brazil . Email: eufranio@ufmg.br.

Publikováno v: RSC medicinal chemistry [RSC Med Chem] 2020 Jul 13; Vol. 11 (10), pp. 1145-1160. Date of Electronic Publication: 2020 Jul 13 (Print Publication: 2020).

5-Chloroquinolin-8-yl furan-2-carboxylate

Autor: Juan C. Tenorio, Geraldine Hernandez, Rodolfo Moreno-Fuquen, Javier Ellena, de Simone Ca

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Acta Crystallographica Section E: Structure Reports
Acta Crystallographica Section E, Vol 69, Iss 4, Pp o501-o501 (2013)

In the title compound, C14H8ClNO3, the central ester CO2 group is twisted away from the quinoline and furoyl rings by 57.46 (5) and 2.0 (1)°, respectively. In the crystal, molecules are linked by weak C—H...O interactions, forming chains in [001].

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5719feeec9f84833627706c8d2a76d66

Design of hybrid molecules as antimycobacterial compounds: Synthesis of isoniazid-naphthoquinone derivatives and their activity against susceptible and resistant strains of Mycobacterium tuberculosis.

Autor: Reis WJ; Institute of Exact Sciences, Department of Chemistry, Federal University of Minas Gerais, Belo Horizonte 31270-901, MG, Brazil., Bozzi ÍAO; Institute of Exact Sciences, Department of Chemistry, Federal University of Minas Gerais, Belo Horizonte 31270-901, MG, Brazil., Ribeiro MF; Institute of Exact Sciences, Department of Chemistry, Federal University of Minas Gerais, Belo Horizonte 31270-901, MG, Brazil., Halicki PCB; Mycobacteria Laboratory, School of Medicine, Federal University of Rio Grande, Rio Grande 96200-190, RS, Brazil., Ferreira LA; Mycobacteria Laboratory, School of Medicine, Federal University of Rio Grande, Rio Grande 96200-190, RS, Brazil., Almeida da Silva PE; Mycobacteria Laboratory, School of Medicine, Federal University of Rio Grande, Rio Grande 96200-190, RS, Brazil., Ramos DF; Mycobacteria Laboratory, School of Medicine, Federal University of Rio Grande, Rio Grande 96200-190, RS, Brazil. Electronic address: danielaramos@furg.br., de Simone CA; Institute of Physics, University of São Paulo, São Carlos 13560-160, SP, Brazil., da Silva Júnior EN; Institute of Exact Sciences, Department of Chemistry, Federal University of Minas Gerais, Belo Horizonte 31270-901, MG, Brazil. Electronic address: eufranio@ufmg.br.

Publikováno v: Bioorganic & medicinal chemistry [Bioorg Med Chem] 2019 Sep 15; Vol. 27 (18), pp. 4143-4150. Date of Electronic Publication: 2019 Jul 27.