Engineered phage with antibacterial CRISPR–Cas selectively reduce E. coli burden in mice.

Autor: Gencay, Yilmaz Emre, Jasinskytė, Džiuginta, Robert, Camille, Semsey, Szabolcs, Martínez, Virginia, Petersen, Anders Østergaard, Brunner, Katja, de Santiago Torio, Ana, Salazar, Alex, Turcu, Iszabela Cristiana, Eriksen, Melissa Kviesgaard, Koval, Lev, Takos, Adam, Pascal, Ricardo, Schou, Thea Staffeldt, Bayer, Lone, Bryde, Tina, Johansen, Katja Chandelle, Bak, Emilie Glad, Smrekar, Frenk

Publikováno v: Nature Biotechnology; Feb2024, Vol. 42 Issue 2, p265-274, 10p

Engineered phage with antibacterial CRISPR–Cas selectively reduce E. coli burden in mice

Autor: Yilmaz Emre Gencay, Džiuginta Jasinskytė, Camille Robert, Szabolcs Semsey, Virginia Martínez, Anders Østergaard Petersen, Katja Brunner, Ana de Santiago Torio, Alex Salazar, Iszabela Cristiana Turcu, Melissa Kviesgaard Eriksen, Lev Koval, Adam Takos, Ricardo Pascal, Thea Staffeldt Schou, Lone Bayer, Tina Bryde, Katja Chandelle Johansen, Emilie Glad Bak, Frenk Smrekar, Timothy B. Doyle, Michael J. Satlin, Aurelie Gram, Joana Carvalho, Lene Jessen, Björn Hallström, Jonas Hink, Birgitte Damholt, Alice Troy, Mette Grove, Jasper Clube, Christian Grøndahl, Jakob Krause Haaber, Eric van der Helm, Milan Zdravkovic, Morten Otto Alexander Sommer

Publikováno v: Nature Biotechnology.

Antibiotic treatments have detrimental effects on the microbiome and lead to antibiotic resistance. To develop a phage therapy against a diverse range of clinically relevant Escherichia coli, we screened a library of 162 wild-type (WT) phages, identi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::991778a52088880ff2605e3ce9c7f027
https://doi.org/10.1038/s41587-023-01759-y

Organic electron donors and terminal electron acceptors structure anaerobic microbial communities and interactions in a permanently stratified sulfidic lake

Autor: Ana De Santiago Torio, Vanja Klepac-Ceraj, Tanja Bosak, Serry Park, Connie A. Rojas

Publikováno v: Frontiers in Microbiology
Frontiers in Microbiology, Vol 12 (2021)

The extent to which nutrients structure microbial communities in permanently stratified lakes is not well understood. This study characterized microbial communities from the anoxic layers of the meromictic and sulfidic Fayetteville Green Lake (FGL),

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b636685e7bdb08e0c44348cbf9cd867d
https://doi.org/10.1101/2021.02.16.431432

System-Wide Adaptations of Desulfovibrio alaskensis G20 to Phosphate-Limited Conditions

Autor: Hans K. Carlson, Nicki Watson, Roger E. Summons, Mirna Daye, Jennifer V. Kuehl, Adam M. Deutschbauer, Florence Schubotz, Ana de Santiago-Torio, Adam P. Arkin, Tanja Bosak

Publikováno v: PLoS ONE, Vol 11, Iss 12, p e0168719 (2016)
Bosak, T; Schubotz, F; De Santiago-Torio, A; Kuehl, JV; Carlson, HK; Watson, N; et al.(2016). System-wide adaptations of Desulfovibrio alaskensis G20 to phosphate-limited conditions. PLoS ONE, 11(12). doi: 10.1371/journal.pone.0168719. Lawrence Berkeley National Laboratory: Lawrence Berkeley National Laboratory. Retrieved from: http://www.escholarship.org/uc/item/1879b7dr
PLoS
PloS one, vol 11, iss 12
PLoS ONE

The prevalence of lipids devoid of phosphorus suggests that the availability of phosphorus limits microbial growth and activity in many anoxic, stratified environments. To better understand the response of anaerobic bacteria to phosphate limitation a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19780be8146635419401c52a85e61109
http://europepmc.org/articles/PMC5193443?pdf=render

Facultative Control of Matrix Production Optimizes Competitive Fitness in Pseudomonas aeruginosa PA14 Biofilm Models

Autor: Alexa Price-Whelan, Georgia R. Squyres, Joao B. Xavier, Yu Cheng Lin, Ana de Santiago Torio, Jonas Stenløkke Madsen, Lars E. P. Dietrich, Angela Song, Søren J. Sørensen, William Cole Cornell

Publikováno v: Applied and Environmental Microbiology. 81:8414-8426

As biofilms grow, resident cells inevitably face the challenge of resource limitation. In the opportunistic pathogen Pseudomonas aeruginosa PA14, electron acceptor availability affects matrix production and, as a result, biofilm morphogenesis. The se

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd00e386b3d026530ad9ac907068c69e
https://doi.org/10.1128/aem.02628-15