Longitudinal changes in cardiac function after cisplatin-based chemotherapy for testicular cancer

Autor: Hendrika Boezen, de Rudolf Boer, Johan Lefrandt, van den Maarten Berg, Yoran M. Hummel, Adriaan A. Voors, Richard van Altena, Janine Nuver, de Elisabeth G. E. Vries, Jourik A. Gietema, Andries J. Smit

Publikováno v: Annals of Oncology, 22(10), 2286-2293. Oxford University Press

Background: Cross-sectional studies showed that treatment with cisplatin chemotherapy for testicular cancer is associated with an increased incidence of cardiac dysfunction. We investigated longitudinal progression of and contributing factors to card

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6db414912c2fae37faa7272767a9a128
https://doi.org/10.1093/annonc/mdr408

Reduced regional myocardial perfusion reserve is associated with impaired contractile performance in idiopathic dilated cardiomyopathy

Autor: P. A. van der Vleuten, LM van Wijk, Adriaan A. Voors, de Rudolf Boer, van Dirk Veldhuisen, Daniel D. Lubbers, R.M. De Jong, Riemer H. J. A. Slart, R. A. Tio, Tineke P. Willems

Publikováno v: Netherlands Heart Journal. 17:470-474

Background. In idiopathic dilated cardiomyopathy (IDC) an imbalance between myocardial oxygen consumption and supply has been postulated. Subclinical myocardial ischaemia may contribute to progressive deterioration of left ventricular function. The r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3da7767f87ba10e6bffbec520cc335bb
https://doi.org/10.1007/bf03086306

The effects of the PPAR-gamma gonist pioglitazone on plasma concentrations of circulating vasoactive factors in type II diabetes mellitus

Autor: Frans Boomsma, de Rudolf Boer, Frank L.J. Visseren, I. Kuipers, F. M. A. C. Martens

Publikováno v: Journal of Human Hypertension, 24, 74-76. Nature Publishing Group
JOURNAL OF HUMAN HYPERTENSION, 24(1), 74-76. Nature Publishing Group

The use of the peroxisome proliferator-activated receptor-gamma (PPAR-gamma) agonist pioglitazone, which is registered as an oral antidiabetic drug, has consistently been associated with a decrease in blood pressure (BP) of about 3-5 mm Hg. The prese

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4591a05c5fd71a9ed1a1ed62c591292
https://hdl.handle.net/11370/75976c3c-12b2-42e5-bad5-285962eb0ae9

P427Endonuclease G-like-1 (EXOG), a mitochondrial endo/exonuclease has a role in mitochondrial function and ROS mediated cardiomyocyte hypertrophy

Autor: Wardit Tigchelaar, de Rudolf Boer, Hongjuan Yu, van Wiekert Gilst, Herman H W Silljé

Publikováno v: Cardiovascular Research. 103:S78.4-S79

Purpose: The heart is one of the most energy consuming organs. This energy is used to maintain proper contractile function and is produced mainly in the mitochondria by oxidative phosphorylation (OXPHOS). The production of reactive oxygen species (RO

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5244c37cf6b69d674111192188ca4276
https://doi.org/10.1093/cvr/cvu091.107

Additional use of immunostaining for active caspade 3 and cleaved actin and PARP fragments to detect apoptosis in patients with chronic heart failure

Autor: Albert J. H. Suurmeijer, N. de Jonge, Rmhj Brouwer, de Rudolf Boer, Greg M. Cole, van Dirk Veldhuisen, J. Van Der Wijk

Publikováno v: Journal of Cardiac Failure, 6, 330-337
JOURNAL OF CARDIAC FAILURE, 6(4), 330-337. Churchill Livingstone
Journal of Cardiac Failure, 6, pp. 330-337

Background: Apoptosis might play a role in the pathophysiology of chronic heart failure (CHF). Detection of apoptosis in tissue mostly relies on the terminal deoxynucleotidyl transferase nick-end labeling (TUNEL) method. Recent studies showed, howeve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09bb3949b3246283f8ebe94cf32a3482
http://hdl.handle.net/2066/185857