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A moderate metal-binding hydrazone meets the criteria for a bioinorganic approach towards Parkinson's disease: Therapeutic potential, blood-brain barrier crossing evaluation and preliminary toxicological studies.

Autor: Cukierman DS; Department of Chemistry, Pontifical Catholic University of Rio de Janeiro, Rio de Janeiro 22451-900, Brazil., Pinheiro AB; Department of Chemistry, Pontifical Catholic University of Rio de Janeiro, Rio de Janeiro 22451-900, Brazil., Castiñeiras-Filho SL; Department of Chemistry, Pontifical Catholic University of Rio de Janeiro, Rio de Janeiro 22451-900, Brazil., da Silva AS; Department of Chemistry, Pontifical Catholic University of Rio de Janeiro, Rio de Janeiro 22451-900, Brazil., Miotto MC; Max Planck Laboratory for Structural Biology, Chemistry and Molecular Biophysics of Rosario (MPLbioR, UNR-MPIbpC) and Instituto de Investigaciones para el Descubrimiento de Fármacos de Rosario (IIDEFAR, UNR-CONICET), Universidad Nacional de Rosario, Rosario S2002LRK, Argentina., De Falco A; Department of Chemistry, Pontifical Catholic University of Rio de Janeiro, Rio de Janeiro 22451-900, Brazil., de P Ribeiro T; Department of Biochemistry, Federal University of Rio de Janeiro, Rio de Janeiro 21941-909, Brazil., Maisonette S; Department of Psychology, Pontifical Catholic University of Rio de Janeiro, Rio de Janeiro 22451-900, Brazil., da Cunha AL; Department of Chemistry, Pontifical Catholic University of Rio de Janeiro, Rio de Janeiro 22451-900, Brazil., Hauser-Davis RA; Department of Chemistry, Pontifical Catholic University of Rio de Janeiro, Rio de Janeiro 22451-900, Brazil., Landeira-Fernandez J; Department of Psychology, Pontifical Catholic University of Rio de Janeiro, Rio de Janeiro 22451-900, Brazil., Aucélio RQ; Department of Chemistry, Pontifical Catholic University of Rio de Janeiro, Rio de Janeiro 22451-900, Brazil., Outeiro TF; Department of Neurodegeneration and Restorative Research, University Medical Center Goettingen, Goettingen, Germany., Pereira MD; Department of Biochemistry, Federal University of Rio de Janeiro, Rio de Janeiro 21941-909, Brazil., Fernández CO; Max Planck Laboratory for Structural Biology, Chemistry and Molecular Biophysics of Rosario (MPLbioR, UNR-MPIbpC) and Instituto de Investigaciones para el Descubrimiento de Fármacos de Rosario (IIDEFAR, UNR-CONICET), Universidad Nacional de Rosario, Rosario S2002LRK, Argentina., Rey NA; Department of Chemistry, Pontifical Catholic University of Rio de Janeiro, Rio de Janeiro 22451-900, Brazil. Electronic address: nicoarey@puc-rio.br.

Publikováno v: Journal of inorganic biochemistry [J Inorg Biochem] 2017 May; Vol. 170, pp. 160-168. Date of Electronic Publication: 2017 Feb 22.

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