Targeting CCL2/CCR2 Signaling Overcomes MEK Inhibitor Resistance in Acute Myeloid Leukemia.

Autor: Modak RV; Division of Oncological Sciences, Oregon Health & Science University, Portland, Oregon.; Knight Cancer Institute, Oregon Health & Science University, Portland, Oregon.; Department of Molecular and Medical Genetics, Oregon Health & Science University, Portland, Oregon.; Department of Cell, Developmental, & Cancer Biology, Oregon Health & Science University, Portland, Oregon., de Oliveira Rebola KG; Division of Oncological Sciences, Oregon Health & Science University, Portland, Oregon.; Knight Cancer Institute, Oregon Health & Science University, Portland, Oregon.; Department of Molecular and Medical Genetics, Oregon Health & Science University, Portland, Oregon.; Department of Cell, Developmental, & Cancer Biology, Oregon Health & Science University, Portland, Oregon., McClatchy J; Division of Oncological Sciences, Oregon Health & Science University, Portland, Oregon.; Knight Cancer Institute, Oregon Health & Science University, Portland, Oregon.; Department of Molecular and Medical Genetics, Oregon Health & Science University, Portland, Oregon.; Department of Cell, Developmental, & Cancer Biology, Oregon Health & Science University, Portland, Oregon., Mohammadhosseini M; Division of Oncological Sciences, Oregon Health & Science University, Portland, Oregon.; Knight Cancer Institute, Oregon Health & Science University, Portland, Oregon.; Department of Molecular and Medical Genetics, Oregon Health & Science University, Portland, Oregon.; Department of Cell, Developmental, & Cancer Biology, Oregon Health & Science University, Portland, Oregon., Damnernsawad A; Knight Cancer Institute, Oregon Health & Science University, Portland, Oregon.; Department of Cell, Developmental, & Cancer Biology, Oregon Health & Science University, Portland, Oregon.; Department of Biology, Faculty of Science, Mahidol University, Bangkok, Thailand., Kurtz SE; Division of Oncological Sciences, Oregon Health & Science University, Portland, Oregon.; Knight Cancer Institute, Oregon Health & Science University, Portland, Oregon.; Department of Cell, Developmental, & Cancer Biology, Oregon Health & Science University, Portland, Oregon., Eide CA; Division of Oncological Sciences, Oregon Health & Science University, Portland, Oregon.; Knight Cancer Institute, Oregon Health & Science University, Portland, Oregon., Wu G; Division of Bioinformatics & Computational Biology, Oregon Health & Science University, Portland, Oregon., Laderas T; Division of Bioinformatics & Computational Biology, Oregon Health & Science University, Portland, Oregon., Nechiporuk T; Knight Cancer Institute, Oregon Health & Science University, Portland, Oregon.; Department of Cell, Developmental, & Cancer Biology, Oregon Health & Science University, Portland, Oregon., Gritsenko MA; Pacific Northwest National Laboratory, Richland, Washington., Hansen JR; Pacific Northwest National Laboratory, Richland, Washington., Hutchinson C; Pacific Northwest National Laboratory, Richland, Washington., Gosline SJC; Pacific Northwest National Laboratory, Richland, Washington.; Department of Biomedical Engineering, School of Medicine, Oregon Health & Science University, Portland, Oregon., Piehowski P; Pacific Northwest National Laboratory, Richland, Washington., Bottomly D; Division of Bioinformatics & Computational Biology, Oregon Health & Science University, Portland, Oregon., Short N; Department of Leukemia, MD Anderson Cancer Center, Houston, Texas., Rodland K; Pacific Northwest National Laboratory, Richland, Washington., McWeeney SK; Division of Bioinformatics & Computational Biology, Oregon Health & Science University, Portland, Oregon., Tyner JW; Knight Cancer Institute, Oregon Health & Science University, Portland, Oregon.; Department of Cell, Developmental, & Cancer Biology, Oregon Health & Science University, Portland, Oregon., Agarwal A; Division of Oncological Sciences, Oregon Health & Science University, Portland, Oregon.; Knight Cancer Institute, Oregon Health & Science University, Portland, Oregon.; Department of Molecular and Medical Genetics, Oregon Health & Science University, Portland, Oregon.; Department of Cell, Developmental, & Cancer Biology, Oregon Health & Science University, Portland, Oregon.

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2024 May 15; Vol. 30 (10), pp. 2245-2259.