Connecting genomic and proteomic signatures of amyloid burden in the brain.

Autor: Puerta R; Ace Alzheimer Center Barcelona - Universitat Internacional de Catalunya, Spain.; Universitat de Barcelona (UB)., de Rojas I; Ace Alzheimer Center Barcelona - Universitat Internacional de Catalunya, Spain.; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain., García-González P; Ace Alzheimer Center Barcelona - Universitat Internacional de Catalunya, Spain.; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain., Olivé C; Ace Alzheimer Center Barcelona - Universitat Internacional de Catalunya, Spain., Sotolongo-Grau O; Ace Alzheimer Center Barcelona - Universitat Internacional de Catalunya, Spain., García-Sánchez A; Ace Alzheimer Center Barcelona - Universitat Internacional de Catalunya, Spain., García-Gutiérrez F; Ace Alzheimer Center Barcelona - Universitat Internacional de Catalunya, Spain., Montrreal L; Ace Alzheimer Center Barcelona - Universitat Internacional de Catalunya, Spain., Pablo Tartari J; Ace Alzheimer Center Barcelona - Universitat Internacional de Catalunya, Spain., Sanabria Á; Ace Alzheimer Center Barcelona - Universitat Internacional de Catalunya, Spain.; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain., Pytel V; Ace Alzheimer Center Barcelona - Universitat Internacional de Catalunya, Spain.; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain., Lage C; Neurology Service, Marqués de Valdecilla University Hospital (University of Cantabria and IDIVAL), Santander, Spain.; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain., Quintela I; Grupo de Medicina Xenómica, Centro Nacional de Genotipado (CEGEN-PRB3-ISCIII). Universidade de Santiago de Compostela, Santiago de Compostela, Spain., Aguilera N; Ace Alzheimer Center Barcelona - Universitat Internacional de Catalunya, Spain., Rodriguez-Rodriguez E; Neurology Service, Marqués de Valdecilla University Hospital (University of Cantabria and IDIVAL), Santander, Spain.; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain., Alarcón-Martín E; Ace Alzheimer Center Barcelona - Universitat Internacional de Catalunya, Spain., Orellana A; Ace Alzheimer Center Barcelona - Universitat Internacional de Catalunya, Spain.; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain., Pastor P; Unit of Neurodegenerative diseases, Department of Neurology, University Hospital Germans Trias i Pujol, Badalona, Barcelona, Spain.; The Germans Trias i Pujol Research Institute (IGTP), Badalona, Barcelona, Spain., Pérez-Tur J; Unitat de Genètica Molecular, Institut de Biomedicina de València-CSIC, Valencia, Spain.; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.; Unidad Mixta de Neurologia Genètica, Instituto de Investigación Sanitaria La Fe, Valencia, Spain., Piñol-Ripoll G; Unitat Trastorns Cognitius, Hospital Universitari Santa Maria de Lleida, Lleida, Spain.; Institut de Recerca Biomedica de Lleida (IRBLLeida), Lleida, Spain., de Munian AL; Department of Neurology. Hospital Universitario Donostia. San Sebastian, Spain.; Department of Neurosciences. Faculty of Medicine and Nursery. University of the Basque Country, San Sebastián, Spain.; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.; Neurosciences Area. Instituto Biodonostia. San Sebastian, Spain., García-Alberca JM; Alzheimer Research Center & Memory Clinic, Andalusian Institute for Neuroscience, Málaga, Spain.; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain., Royo JL; Departamento de Especialidades Quirúrgicas, Bioquímica e Inmunología. School of Medicine. University of Malaga. Málaga, Spain., Bullido MJ; Centro de Biología Molecular Severo Ochoa (UAM-CSIC).; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.; Instituto de Investigacion Sanitaria 'Hospital la Paz' (IdIPaz), Madrid, Spain.; Universidad Autónoma de Madrid., Álvarez V; Laboratorio de Genética. Hospital Universitario Central de Asturias, Oviedo, Spain.; Instituto de Investigación Sanitaria del Principado de Asturias (ISPA)., Real LM; Unidad Clínica de Enfermedades Infecciosas y Microbiología.Hospital Universitario de Valme, Sevilla, Spain.; Departamento de Especialidades Quirúrgicas, Bioquímica e Inmunología. School of Medicine. University of Malaga. Málaga, Spain., Anchuelo AC; Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Hospital Clínico San Carlos., Gómez-Garre D; Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Hospital Clínico San Carlos.; Laboratorio de Riesgo Cardiovascular y Microbiota, Hospital Clínico San Carlos; Departamento de Fisiología, Facultad de Medicina, Universidad Complutense de Madrid (UCM).; Biomedical Research Networking Center in Cardiovascular Diseases (CIBERCV), Madrid, Spain., Larrad MTM; Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Hospital Clínico San Carlos.; Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM)., Franco-Macías E; Dementia Unit, Department of Neurology, Hospital Universitario Virgen del Rocío, Instituto de Biomedicina de Sevilla (IBiS), Sevilla, Spain., Mir P; Unidad de Trastornos del Movimiento, Servicio de Neurología y Neurofisiología. Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Seville, Spain.; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain., Medina M; CIEN Foundation/Queen Sofia Foundation Alzheimer Center.; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain., Sánchez-Valle R; Alzheimer's disease and other cognitive disorders unit. Service of Neurology. Hospital Clínic of Barcelona. Institut d'Investigacions Biomèdiques August Pi i Sunyer, University of Barcelona, Barcelona, Spain., Dols-Icardo O; Department of Neurology, Sant Pau Memory Unit, Sant Pau Biomedical Research Institute, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain., Sáez ME; CAEBI, Centro Andaluz de Estudios Bioinformáticos, Sevilla, Spain., Carracedo Á; Grupo de Medicina Xenómica, Centro Nacional de Genotipado (CEGEN-PRB3-ISCIII). Universidade de Santiago de Compostela, Santiago de Compostela, Spain.; Fundación Pública Galega de Medicina Xenómica - CIBERER-IDIS, Santiago de Compostela, Spain., Tárraga L; Ace Alzheimer Center Barcelona - Universitat Internacional de Catalunya, Spain.; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain., Alegret M; Ace Alzheimer Center Barcelona - Universitat Internacional de Catalunya, Spain.; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain., Valero S; Ace Alzheimer Center Barcelona - Universitat Internacional de Catalunya, Spain.; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain., Marquié M; Ace Alzheimer Center Barcelona - Universitat Internacional de Catalunya, Spain.; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain., Boada M; Ace Alzheimer Center Barcelona - Universitat Internacional de Catalunya, Spain.; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain., Juan PS; Neurology Service, Marqués de Valdecilla University Hospital (University of Cantabria and IDIVAL), Santander, Spain.; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain., Cavazos JE; South Texas Medical Science Training Program, University of Texas Health San Antonio, San Antonio.; Glenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr, San Antonio, TX 78229 USA., Cabrera A; Neuroscience Therapeutic Area, Janssen Research & Development, Turnhoutseweg 30, 2340 Beerse, Belgium., Cano A; Ace Alzheimer Center Barcelona - Universitat Internacional de Catalunya, Spain.; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.

Publikováno v: MedRxiv : the preprint server for health sciences [medRxiv] 2024 Sep 06. Date of Electronic Publication: 2024 Sep 06.

Biological Emergences : Evolution by Natural Experiment

Autor: Robert G. B. Reid

A critique of selectionism and the proposal of an alternate theory of emergent evolution that is causally sufficient for evolutionary biology.Natural selection is commonly interpreted as the fundamental mechanism of evolution. Questions about how sel