Effects of dopamine β-hydroxylase inhibition in pressure overload-induced right ventricular failure.

Autor: Andersen S; Department of Cardiology Aarhus University Hospital Aarhus Denmark.; Department of Clinical Medicine Aarhus University Aarhus Denmark., Axelsen JS; Department of Cardiology Aarhus University Hospital Aarhus Denmark.; Department of Clinical Medicine Aarhus University Aarhus Denmark., Nielsen-Kudsk AH; Department of Cardiology Aarhus University Hospital Aarhus Denmark.; Department of Clinical Medicine Aarhus University Aarhus Denmark., Schwab J; Department of Cardiology Aarhus University Hospital Aarhus Denmark.; Department of Clinical Medicine Aarhus University Aarhus Denmark., Jensen CD; Department of Cardiology Aarhus University Hospital Aarhus Denmark.; Department of Clinical Medicine Aarhus University Aarhus Denmark., Ringgaard S; Department of Clinical Medicine, MR Research Centre Aarhus University Aarhus Denmark., Andersen A; Department of Cardiology Aarhus University Hospital Aarhus Denmark.; Department of Clinical Medicine Aarhus University Aarhus Denmark., Smal R; Department of Pulmonology Amsterdam University Medical Centre Amsterdam The Netherlands., Llucià-Valldeperas A; Department of Pulmonology Amsterdam University Medical Centre Amsterdam The Netherlands., Handoko de Man F; Department of Pulmonology Amsterdam University Medical Centre Amsterdam The Netherlands., Igreja B; Department of Research BIAL, Portela & Cª, S.A. Coronado S. Romão e S. Mamede Portugal., Pires N; Department of Research BIAL, Portela & Cª, S.A. Coronado S. Romão e S. Mamede Portugal.

Publikováno v: Pulmonary circulation [Pulm Circ] 2024 Nov 13; Vol. 14 (4), pp. e70008. Date of Electronic Publication: 2024 Nov 13 (Print Publication: 2024).

Molecular mechanisms and targets of right ventricular fibrosis in pulmonary hypertension

Autor: Bekedam, F. T., Goumans, M. J., Bogaard, H. J., de Man, F. S., Llucià-Valldeperas, A.

Publikováno v: Bekedam, F T, Goumans, M J, Bogaard, H J, de Man, F S & Llucià-Valldeperas, A 2023, ' Molecular mechanisms and targets of right ventricular fibrosis in pulmonary hypertension ', Pharmacology and Therapeutics, vol. 244, 108389 . https://doi.org/10.1016/j.pharmthera.2023.108389

Right ventricular fibrosis is a stress response, predominantly mediated by cardiac fibroblasts. This cell population is sensitive to increased levels of pro-inflammatory cytokines, pro-fibrotic growth factors and mechanical stimulation. Activation of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5feca7c76e1fe5d650576b3e445663d5
https://doi.org/10.1016/j.pharmthera.2023.108389

A roadmap for therapeutic discovery in pulmonary hypertension associated with left heart failure. A scientific statement of the Heart Failure Association (HFA) of the ESC and the ESC Working Group on Pulmonary Circulation & Right Ventricular Function.

Autor: Ameri P; Department of Internal Medicine, University of Genova, Genoa, Italy.; Cardiac, Thoracic, and Vascular Department, IRCCS Ospedale Policlinico San Martino, Genoa, Italy., Mercurio V; Department of Translational Medical Sciences, Interdepartmental Center for Clinical and Translational Research (CIRCET), and Interdepartmental Hypertension Research Center (CIRIAPA), Federico II University, Naples, Italy., Pollesello P; Content and Communication, Branded Products, Orion Pharma, Espoo, Finland., Anker MS; Deutsches Herzzentrum der Charité, Klinik für Kardiologie, Angiologie und Intensivmedizin (Campus CBF), German Centre for Cardiovascular Research (DZHK) partner site Berlin, Berlin Institute of Health Center for Regenerative Therapies (BCRT), Charité Universitätsmedizin Berlin, Berlin, Germany., Backs J; Institute of Experimental Cardiology, University Hospital Heidelberg, University of Heidelberg and DZHK (German Centre for Cardiovascular Research), Partner Site Heidelberg/Mannheim, Heidelberg, Germany., Bayes-Genis A; Heart Institute, Hospital Universitari Germans Trias i Pujol, CIBERCV, Universitat Autònoma de Barcelona, Barcelona, Spain., Borlaug BA; Department of Cardiovascular Diseases, Mayo Clinic, Rochester, MN, USA.; Cardiovascular Research Foundation, New York, NY, USA., Burkhoff D; Cardiovascular Research Foundation, New York, NY, USA., Caravita S; Department of Management, Information and Production Engineering, University of Bergamo, Dalmine (BG), Italy.; Department of Cardiology, Istituto Auxologico Italiano IRCCS Ospedale San Luca, Milan, Italy., Chan SY; Pittsburgh Heart, Lung, and Blood Vascular Medicine Institute, Division of Cardiology, Department of Medicine, University of Pittsburgh School of Medicine and UPMC, Pittsburgh, PA, USA., de Man F; PHEniX laboratory, Department of Pulmonary Medicine, Amsterdam UMC location Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.; Amsterdam Cardiovascular Sciences, Pulmonary Hypertension and Thrombosis, Amsterdam, The Netherlands., Giannakoulas G; First Department of Cardiology, AHEPA University Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece., González A; Program of Cardiovascular Diseases, CIMA Universidad de Navarra and IdiSNA, Pamplona, Spain.; CIBERCV, Madrid, Spain., Guazzi M; University of Milan, Milan, Italy.; Cardiology Division, San Paolo University Hospital, Milan, Italy., Hassoun PM; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University, Baltimore, MD, USA., Hemnes AR; Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Maack C; Comprehensive Heart Failure Center (CHFC) and Medical Clinic I, University Clinic Würzburg, Würzburg, Germany., Madden B; St.Georges Hospital, London, UK., Melenovsky V; Department of Cardiology, Institute for Clinical and Experimental Medicine - IKEM, Prague, Czech Republic., Müller OJ; Department of Internal Medicine V, University Hospital Schleswig-Holstein, and German Centre for Cardiovascular Research (DZHK), Partner site Hamburg/Kiel/Lübeck, Kiel, Germany., Papp Z; Division of Clinical Physiology, Department of Cardiology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary., Pullamsetti SS; Department of Internal Medicine and Excellence Cluster Cardio-Pulmonary Institute (CPI), Justus-Liebig University, Giessen, Germany., Rainer PP; Division of Cardiology, Medical University of Graz, Graz, Austria.; BioTechMed Graz, Graz, Austria.; Department of Medicine, St. Johann in Tirol General Hospital, St. Johann in Tirol, Austria., Redfield MM; Department of Cardiovascular Diseases, Mayo Clinic, Rochester, MN, USA., Rich S; Division of Cardiology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Schiattarella GG; Max-Rubner Center (CMR), Department of Cardiology, Charité-Universitätsmedizin Berlin, Berlin, Germany.; German Centre for Cardiovascular Research (DZHK), Partner Site Berlin, Berlin, Germany.; Translational Approaches in Heart Failure and Cardiometabolic Disease, Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany.; Division of Cardiology, Department of Advanced Biomedical Sciences, Federico II University, Naples, Italy., Skaara H; Pulmonary Hypertension Association Europe, Vienna, Austria., Stellos K; Department of Cardiovascular Research, European Center for Angioscience (ECAS), Heidelberg University, Mannheim, Germany.; German Centre for Cardiovascular Research (Deutsches Zentrum für Herz-Kreislauf-Forschung, DZHK), Heidelberg/Mannheim Partner Site, Heidelberg and Mannheim, Germany.; Department of Cardiology, University Hospital Mannheim, Heidelberg University, Mannheim, Germany.; Biosciences Institute, Vascular Biology and Medicine Theme, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK., Tedford RJ; Division of Cardiology, Department of Medicine, Medical University of South Carolina, Charleston, SC, USA., Thum T; Institute of Molecular and Translational Therapeutic Strategies (IMTTS), Hannover Medical School, Hannover, Germany., Vachiery JL; Department of Cardiology, Hopital Universitaire de Bruxelles Erasme, Brussels, Belgium., van der Meer P; Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., Van Linthout S; Berlin Institute of Health (BIH) at Charité, BIH Center for Regenerative Therapies, University of Medicine, Berlin, Germany.; German Center for Cardiovascular Research (DZHK, partner site Berlin), Berlin, Germany., Pruszczyk P; Department of Internal Medicine and Cardiology, Medical University of Warsaw, Warsaw, Poland., Seferovic P; University of Belgrade Faculty of Medicine, Belgrade University Medical Center, Serbian Academy of Sciences and Arts, Belgrade, Serbia., Coats AJS; Heart Research Institute, Sydney, Australia., Metra M; Cardiology. ASST Spedali Civili and Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Brescia, Italy., Rosano G; IRCCS San Raffaele, Rome, Italy., Rosenkranz S; Department of Cardiology and Cologne Cardiovascular Research Center (CCRC), Heart Center at the University Hospital Cologne, Cologne, Germany.; Center for Molecular Medicine Cologne (CMMC), Faculty of Medicine, University of Cologne, Cologne, Germany., Tocchetti CG; Department of Translational Medical Sciences, Interdepartmental Center for Clinical and Translational Research (CIRCET), and Interdepartmental Hypertension Research Center (CIRIAPA), Federico II University, Naples, Italy.; Center for Basic and Clinical Immunology Research (CISI), Federico II University, Naples, Italy.

Publikováno v: European journal of heart failure [Eur J Heart Fail] 2024 Apr; Vol. 26 (4), pp. 707-729. Date of Electronic Publication: 2024 Apr 19.

Cardiac Safety of Imatinib for the Treatment of Covid-19: Results from a Randomized, Double Blind, Placebo-Controlled Trial

Autor: Duijvelaar, E., Vanhove, A., Schippers, J. R., Smeele, P. J., de Man, F. S., Pinto, Y. M., Bogaard, H. J.

Publikováno v: American Journal of Respiratory and Critical Care Medicine, 205. American Thoracic Society
Duijvelaar, E, Vanhove, A, Schippers, J R, Smeele, P J, de Man, F S, Pinto, Y M & Bogaard, H J 2022, ' Cardiac Safety of Imatinib for the Treatment of Covid-19: Results from a Randomized, Double Blind, Placebo-Controlled Trial ', American Journal of Respiratory and Critical Care Medicine, vol. 205 .

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::5b70f7d152156f53852df64c2b19d07c
https://research.vumc.nl/en/publications/38fdc1ea-5b81-4269-ae39-e6e6f9992dfd

Right Atrial Adaptation to Pressure-Overload in Pulmonary Arterial Hypertension

Autor: Van Wezenbeek, J., Wessels, J. N., Niessen, H. W. M., Marcus, J.T., Meijboom, L. J., Noordegraaf, A. Vonk, Goumans, M., Bogaard, H. J., de Man, F. S.

Publikováno v: American Journal of Respiratory and Critical Care Medicine, 205. American Thoracic Society
Van Wezenbeek, J, Wessels, J N, Niessen, H W M, Marcus, J T, Meijboom, L J, Noordegraaf, A V, Goumans, M, Bogaard, H J & de Man, F S 2022, ' Right Atrial Adaptation to Pressure-Overload in Pulmonary Arterial Hypertension ', American Journal of Respiratory and Critical Care Medicine, vol. 205 .

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e8d3c5764cd7cb34c6c50afa6cd7c64
https://doi.org/10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a5303