STK19 facilitates the clearance of lesion-stalled RNAPII during transcription-coupled DNA repair.

Autor: van den Heuvel D; Department of Human Genetics, Leiden University Medical Center, Leiden, the Netherlands., Rodríguez-Martínez M; Mechanisms of Transcription Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK., van der Meer PJ; Department of Human Genetics, Leiden University Medical Center, Leiden, the Netherlands., Nieto Moreno N; Department of Cellular and Molecular Medicine, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen, Denmark., Park J; Center for Genomic Integrity, Institute for Basic Science, Ulsan, Republic of Korea., Kim HS; Center for Genomic Integrity, Institute for Basic Science, Ulsan, Republic of Korea., van Schie JJM; Department of Human Genetics, Leiden University Medical Center, Leiden, the Netherlands., Wondergem AP; Department of Human Genetics, Leiden University Medical Center, Leiden, the Netherlands., D'Souza A; Center for Genomic Integrity, Institute for Basic Science, Ulsan, Republic of Korea., Yakoub G; Department of Human Genetics, Leiden University Medical Center, Leiden, the Netherlands., Herlihy AE; Mechanisms of Transcription Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK., Kashyap K; Department of Cellular and Molecular Medicine, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen, Denmark., Boissière T; Mechanisms of Transcription Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK; Department of Cellular and Molecular Medicine, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen, Denmark., Walker J; Mechanisms of Transcription Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK., Mitter R; Bioinformatics and Biostatistics, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK., Apelt K; Department of Human Genetics, Leiden University Medical Center, Leiden, the Netherlands., de Lint K; Department of Clinical Genetics, Section Oncogenetics, Cancer Center Amsterdam, Amsterdam University Medical Center, Amsterdam, the Netherlands., Kirdök I; Department of Clinical Genetics, Section Oncogenetics, Cancer Center Amsterdam, Amsterdam University Medical Center, Amsterdam, the Netherlands., Ljungman M; Department of Radiation Oncology, University of Michigan, Ann Arbor, MI, USA; Department of Environmental Health Sciences, Rogel Cancer Center and Center for RNA Biomedicine, University of Michigan, Ann Arbor, MI, USA., Wolthuis RMF; Department of Clinical Genetics, Section Oncogenetics, Cancer Center Amsterdam, Amsterdam University Medical Center, Amsterdam, the Netherlands., Cramer P; Max Planck Institute for Multidisciplinary Sciences, Department of Molecular Biology, 37077 Göttingen, Germany., Schärer OD; Center for Genomic Integrity, Institute for Basic Science, Ulsan, Republic of Korea; Department of Biological Sciences, Ulsan National Institute of Science and Technology, Ulsan, Republic of Korea., Kokic G; Max Planck Institute for Multidisciplinary Sciences, Department of Molecular Biology, 37077 Göttingen, Germany. Electronic address: gkokic@gmail.com., Svejstrup JQ; Mechanisms of Transcription Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK; Department of Cellular and Molecular Medicine, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen, Denmark. Electronic address: jsvejstrup@sund.ku.dk., Luijsterburg MS; Department of Human Genetics, Leiden University Medical Center, Leiden, the Netherlands. Electronic address: m.luijsterburg@lumc.nl.

Publikováno v: Cell [Cell] 2024 Dec 12; Vol. 187 (25), pp. 7107-7125.e25. Date of Electronic Publication: 2024 Nov 14.

Genome-wide CRISPR-Cas9 screen to identify new proteins involved in intracellular cholesterol transport

Autor: Meurs, A., De Lint, K., Zelcer, N.

Publikováno v: In Atherosclerosis August 2022 355

Publisher Correction: BIRC2-BIRC3 amplification: a potentially druggable feature of a subset of head and neck cancers in patients with Fanconi anemia.

Autor: Roohollahi K; Department of Clinical Genetics, Amsterdam UMC, Location VUMC, De Boelelaan 1117, 1118, 1081 HV, Amsterdam, The Netherlands. k.roohollahi@amsterdamumc.nl., de Jong Y; Department of Clinical Genetics, Amsterdam UMC, Location VUMC, De Boelelaan 1117, 1118, 1081 HV, Amsterdam, The Netherlands., Pai G; Department of Clinical Genetics, Amsterdam UMC, Location VUMC, De Boelelaan 1117, 1118, 1081 HV, Amsterdam, The Netherlands., Zaini MA; Department of Clinical Genetics, Amsterdam UMC, Location VUMC, De Boelelaan 1117, 1118, 1081 HV, Amsterdam, The Netherlands., de Lint K; Department of Clinical Genetics, Amsterdam UMC, Location VUMC, De Boelelaan 1117, 1118, 1081 HV, Amsterdam, The Netherlands., Sie D; Department of Clinical Genetics, Amsterdam UMC, Location VUMC, De Boelelaan 1117, 1118, 1081 HV, Amsterdam, The Netherlands., Rooimans MA; Department of Clinical Genetics, Amsterdam UMC, Location VUMC, De Boelelaan 1117, 1118, 1081 HV, Amsterdam, The Netherlands., Rockx D; Department of Clinical Genetics, Amsterdam UMC, Location VUMC, De Boelelaan 1117, 1118, 1081 HV, Amsterdam, The Netherlands., Hoskins EE; Medpace, Cincinnati, OH, 45227, USA., Ameziane N; Department of Clinical Genetics, Amsterdam UMC, Location VUMC, De Boelelaan 1117, 1118, 1081 HV, Amsterdam, The Netherlands., Wolthuis R; Department of Clinical Genetics, Amsterdam UMC, Location VUMC, De Boelelaan 1117, 1118, 1081 HV, Amsterdam, The Netherlands., Joenje H; Department of Clinical Genetics, Amsterdam UMC, Location VUMC, De Boelelaan 1117, 1118, 1081 HV, Amsterdam, The Netherlands., Wells SI; Division of Oncology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 45229, USA., Dorsman J; Department of Clinical Genetics, Amsterdam UMC, Location VUMC, De Boelelaan 1117, 1118, 1081 HV, Amsterdam, The Netherlands. jc.dorsman@amsterdamumc.nl.

Publikováno v: Scientific reports [Sci Rep] 2022 Apr 06; Vol. 12 (1), pp. 5768. Date of Electronic Publication: 2022 Apr 06.

ELOF1 is a transcription-coupled DNA repair factor that directs RNA polymerase II ubiquitylation.

Autor: van der Weegen Y; Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands., de Lint K; Department of Clinical Genetics, Section Oncogenetics, Cancer Center Amsterdam, Amsterdam University Medical Center, Amsterdam, The Netherlands., van den Heuvel D; Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands., Nakazawa Y; Department of Genetics, Research Institute of Environmental Medicine (RIeM), Nagoya University, Nagoya, Japan.; Department of Human Genetics and Molecular Biology, Nagoya University Graduate School of Medicine, Nagoya, Japan., Mevissen TET; Howard Hughes Medical Institute and Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA., van Schie JJM; Department of Clinical Genetics, Section Oncogenetics, Cancer Center Amsterdam, Amsterdam University Medical Center, Amsterdam, The Netherlands., San Martin Alonso M; Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands.; Oncode Institute, Utrecht, The Netherlands., Boer DEC; Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands., González-Prieto R; Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden, The Netherlands., Narayanan IV; Department of Radiation Oncology, University of Michigan, Ann Arbor, MI, USA., Klaassen NHM; Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands., Wondergem AP; Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands., Roohollahi K; Department of Clinical Genetics, Section Oncogenetics, Cancer Center Amsterdam, Amsterdam University Medical Center, Amsterdam, The Netherlands., Dorsman JC; Department of Clinical Genetics, Section Oncogenetics, Cancer Center Amsterdam, Amsterdam University Medical Center, Amsterdam, The Netherlands., Hara Y; Department of Genetics, Research Institute of Environmental Medicine (RIeM), Nagoya University, Nagoya, Japan.; Department of Human Genetics and Molecular Biology, Nagoya University Graduate School of Medicine, Nagoya, Japan., Vertegaal ACO; Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden, The Netherlands., de Lange J; Department of Clinical Genetics, Section Oncogenetics, Cancer Center Amsterdam, Amsterdam University Medical Center, Amsterdam, The Netherlands., Walter JC; Howard Hughes Medical Institute and Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA., Noordermeer SM; Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands.; Oncode Institute, Utrecht, The Netherlands., Ljungman M; Department of Radiation Oncology, University of Michigan, Ann Arbor, MI, USA.; Department of Environmental Health Sciences, Rogel Cancer Center and Center for RNA Biomedicine, University of Michigan, Ann Arbor, MI, USA., Ogi T; Department of Genetics, Research Institute of Environmental Medicine (RIeM), Nagoya University, Nagoya, Japan.; Department of Human Genetics and Molecular Biology, Nagoya University Graduate School of Medicine, Nagoya, Japan., Wolthuis RMF; Department of Clinical Genetics, Section Oncogenetics, Cancer Center Amsterdam, Amsterdam University Medical Center, Amsterdam, The Netherlands. r.wolthuis@amsterdamumc.nl., Luijsterburg MS; Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands. m.luijsterburg@lumc.nl.

Publikováno v: Nature cell biology [Nat Cell Biol] 2021 Jun; Vol. 23 (6), pp. 595-607. Date of Electronic Publication: 2021 Jun 09.

Broadening Horizons: Exploring mtDAMPs as a Mechanism and Potential Intervention Target in Cardiovascular Diseases.

Autor: Yi Luan¹, Ying Luan², Yuxue Jiao¹, Hui Liu³, Zhen Huang³, Qi Feng⁴, Jinyan Pei⁵, Yang Yang¹ yangyangbio@163.com, Kaidi Ren^6,7 renkd006@163.com

Publikováno v: Aging & Disease. Nov2024, Vol. 15 Issue 6, p2395-2416. 22p.