Increased Levels of Plasma Tumor Necrosis Factor-α Mediate Schizophrenia Symptom Dimensions and Neurocognitive Impairments and Are Inversely Associated with Natural IgM and Paraoxonase 1 Activity

Autor: Maes A, Carvalho Af, Moreira Eg, Maes M, Sirivichayakul S, Kanchanatawan B, Matsumoto Ak, Barbosa Ds, Michelin Ap, Geffard M, de Oliveira Semeão L, de Lima Pedrão Jv

Accumulating evidence suggests that TNF-α-mediated immune-neurotoxicity contributes to cognitive impairments and the overall severity of schizophrenia (OSOS). There are no data whether peripheral IL-6 and IL-4 may affect the phenome of schizophrenia

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0c277724e4d6c1ca1bda78adcb5269b
https://doi.org/10.20944/preprints201911.0135.v1

Reduced paraoxonase 1 activities may explain the comorbidities between temporal lobe epilepsy and depression, anxiety and psychosis.

Autor: Michelin AP; Health Sciences Center, State University of Londrina, Londrina 86038-440, Brazil., Maes MHJ; Department of Psychiatry, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand., Supasitthumrong T; Department of Psychiatry, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand., Limotai C; Chulalongkorn Comprehensive Epilepsy Center of Excellence, King Chulalongkorn Memorial Hospital, The Thai Red Cross Society, Bangkok 10330, Thailand., Matsumoto AK; Health Sciences Center, State University of Londrina, Londrina 86038-440, Brazil., de Oliveira Semeão L; Health Sciences Center, State University of Londrina, Londrina 86038-440, Brazil., de Lima Pedrão JV; Health Sciences Center, State University of Londrina, Londrina 86038-440, Brazil., Moreira EG; Health Sciences Center, State University of Londrina, Londrina 86038-440, Brazil., Kanchanatawan B; Department of Psychiatry, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand., Barbosa DS; Health Sciences Center, State University of Londrina, Londrina 86038-440, Brazil.

Publikováno v: World journal of psychiatry [World J Psychiatry] 2022 Feb 19; Vol. 12 (2), pp. 308-322. Date of Electronic Publication: 2022 Feb 19 (Print Publication: 2022).

Deficit schizophrenia and its features are associated with PON1 Q192R genotypes and lowered paraoxonase 1 (PON1) enzymatic activity: effects on bacterial translocation.

Autor: Matsumoto AK; Health Sciences Graduate Program, Health Sciences Center, State University of Londrina, Londrina, Brazil., Maes M; Department of Psychiatry, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.; Department of Psychiatry, Medical University of Plovdiv, Plovdiv, Bulgaria.; IMPACT Strategic Research Center, Deakin University, Geelong, Australia., Supasitthumrong T; Department of Psychiatry, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand., Maes A; Janssen Pharmaceutica NV, Beerse, Belgium., Michelin AP; Health Sciences Graduate Program, Health Sciences Center, State University of Londrina, Londrina, Brazil., de Oliveira Semeão L; Health Sciences Graduate Program, Health Sciences Center, State University of Londrina, Londrina, Brazil., de Lima Pedrão JV; Health Sciences Graduate Program, Health Sciences Center, State University of Londrina, Londrina, Brazil., Moreira EG; Health Sciences Graduate Program, Health Sciences Center, State University of Londrina, Londrina, Brazil., Kanchanatawan B; Department of Psychiatry, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand., Barbosa DS; Health Sciences Graduate Program, Health Sciences Center, State University of Londrina, Londrina, Brazil.

Publikováno v: CNS spectrums [CNS Spectr] 2021 Aug; Vol. 26 (4), pp. 406-415. Date of Electronic Publication: 2020 Jun 23.

A Randomized Trial of Short-term Treatment with Folic Acid to Reduce the Oxidative Stress of Patients with Chronic Kidney Disease.

Autor: Matsumoto AK; Health Sciences Graduate Program, Health Sciences Center, State University of Londrina, Londrina, PR, Brazil., Michelin AP; Health Sciences Graduate Program, Health Sciences Center, State University of Londrina, Londrina, PR, Brazil., Semeão LO; Health Sciences Graduate Program, Health Sciences Center, State University of Londrina, Londrina, PR, Brazil., Sepúlveda-Loyola W; Program of Masters and Doctoral degree in Rehabilitation Sciences, State University of Londrina, PR, Brazil., de Lima Pedrão JV; Health Sciences Graduate Program, Health Sciences Center, State University of Londrina, Londrina, PR, Brazil., Porto GM; Health Sciences Graduate Program, Health Sciences Center, State University of Londrina, Londrina, PR, Brazil., Arceni BS; Clinical and laboratory pathophysiology Graduate Program, State University of Londrina, PR, Brazil., Moreira EG; Health Sciences Graduate Program, Health Sciences Center, State University of Londrina, Londrina, PR, Brazil., Delfino VDA; Department of Internal Medicine, Nephrology Section, State University of Londrina, Londrina, PR, Brazil., Barbosa DS; Health Sciences Graduate Program, Health Sciences Center, State University of Londrina, Londrina, PR, Brazil.

Publikováno v: Current drug metabolism [Curr Drug Metab] 2021; Vol. 22 (14), pp. 1139-1150.

Increased Oxidative Stress Toxicity and Lowered Antioxidant Defenses in Temporal Lobe Epilepsy and Mesial Temporal Sclerosis: Associations with Psychiatric Comorbidities.

Autor: Maes M; Department of Psychiatry, Faculty of Medicine, King Chulalongkorn Memorial Hospital, Bangkok, Thailand.; Department of Psychiatry, Medical University of Plovdiv, Plovdiv, Bulgaria.; IMPACT Strategic Research Center, Deakin University, Geelong, Australia., Supasitthumrong T; Department of Psychiatry, Faculty of Medicine, King Chulalongkorn Memorial Hospital, Bangkok, Thailand., Limotai C; Chulalongkorn Comprehensive Epilepsy Center of Excellence (CCEC), The Thai Red Cross Society; Division of Neurology, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand., Michelin AP; Health Sciences Graduate Program, Health Sciences Center, State University of Londrina, Londrina, PR, Brazil., Matsumoto AK; Health Sciences Graduate Program, Health Sciences Center, State University of Londrina, Londrina, PR, Brazil., de Oliveira Semão L; Health Sciences Graduate Program, Health Sciences Center, State University of Londrina, Londrina, PR, Brazil., de Lima Pedrão JV; Health Sciences Graduate Program, Health Sciences Center, State University of Londrina, Londrina, PR, Brazil., Moreira EG; Health Sciences Graduate Program, Health Sciences Center, State University of Londrina, Londrina, PR, Brazil., Carvalho AF; Department of Psychiatry, University of Toronto, Toronto, ON, Canada.; Centre for Addiction and Mental Health (CAMH), Toronto, ON, Canada., Sirivichayakul S; Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand., Barbosa DS; Health Sciences Graduate Program, Health Sciences Center, State University of Londrina, Londrina, PR, Brazil., Kanchanatawan B; Department of Psychiatry, Faculty of Medicine, King Chulalongkorn Memorial Hospital, Bangkok, Thailand. drburanee@gmail.com.

Publikováno v: Molecular neurobiology [Mol Neurobiol] 2020 Aug; Vol. 57 (8), pp. 3334-3348. Date of Electronic Publication: 2020 Jun 09.