Sex-specific effects of naturally occurring variants in the dopamine receptor D2 locus on insulin secretion and type 2 diabetes susceptibility.

Autor: Guigas B; Department of Molecular Cell Biology, Leiden University Medical Centre, Leiden, The Netherlands; Department of Parasitology, Leiden University Medical Centre, Leiden, The Netherlands., de Leeuw van Weenen JE, van Leeuwen N, Simonis-Bik AM, van Haeften TW, Nijpels G, Houwing-Duistermaat JJ, Beekman M, Deelen J, Havekes LM, Penninx BW, Vogelzangs N, van 't Riet E, Dehghan A, Hofman A, Witteman JC, Uitterlinden AG, Grarup N, Jørgensen T, Witte DR, Lauritzen T, Hansen T, Pedersen O, Hottenga J, Romijn JA, Diamant M, Kramer MH, Heine RJ, Willemsen G, Dekker JM, Eekhoff EM, Pijl H, de Geus EJ, Slagboom PE, 't Hart LM

Publikováno v: Diabetic medicine : a journal of the British Diabetic Association [Diabet Med] 2014 Aug; Vol. 31 (8), pp. 1001-8. Date of Electronic Publication: 2014 May 02.

Pharmacological modulation of dopamine receptor D2-mediated transmission alters the metabolic phenotype of diet induced obese and diet resistant C57Bl6 mice.

Autor: de Leeuw van Weenen JE; Department of Endocrinology and Metabolic Diseases, Leiden University Medical Center, RC Leiden, The Netherlands., Parlevliet ET, Schröder-van der Elst JP, van den Berg SA, Willems van Dijk K, Romijn JA, Pijl H

Publikováno v: Experimental diabetes research [Exp Diabetes Res] 2011; Vol. 2011, pp. 928523. Date of Electronic Publication: 2011 Apr 06.

The dopamine receptor D2 agonist bromocriptine inhibits glucose-stimulated insulin secretion by direct activation of the alpha2-adrenergic receptors in beta cells.

Autor: de Leeuw van Weenen JE; Department of Endocrinology and Metabolic Diseases, Leiden University Medical Center, Leiden, The Netherlands. j.e.de_leeuw@lumc.nl, Parlevliet ET, Maechler P, Havekes LM, Romijn JA, Ouwens DM, Pijl H, Guigas B

Publikováno v: Biochemical pharmacology [Biochem Pharmacol] 2010 Jun 15; Vol. 79 (12), pp. 1827-36. Date of Electronic Publication: 2010 Feb 04.

Four weeks high fat feeding induces insulin resistance without affecting dopamine release or gene expression patterns in the hypothalamus of C57Bl6 mice.

Autor: de Leeuw van Weenen JE; Department of Endocrinology and Metabolic Diseases, Leiden University Medical Center, Leiden, The Netherlands. j.e.de_leeuw@lumc.nl, Hu L, Jansen-Van Zelm K, de Vries MG, Tamsma JT, Romijn JA, Pijl H

Publikováno v: Brain research [Brain Res] 2009 Jan 23; Vol. 1250, pp. 141-8. Date of Electronic Publication: 2008 Nov 11.