Zobrazeno 1 - 10
of 12
pro vyhledávání: '"de Lange, KM"'
Autor:
Luo, Y, de Lange, KM, Jostins, L, Moutsianas, L, Randall, J, Kennedy, NA, Lamb, CA, McCarthy, S, Ahmad, T, Edwards, C, Serra, EG, Hart, A, Hawkey, C, Mansfield, JC, Mowat, C, Newman, WG, Nichols, S, Pollard, M, Satsangi, J, Simmons, A, Tremelling, M, Uhlig, H, Wilson, DC, Lee, JC, Prescott, NJ, Lees, CW, Mathew, CG, Parkes, M, Barrett, JC, Anderson, CA
To further resolve the genetic architecture of the inflammatory bowel diseases ulcerative colitis and Crohn’s disease, we sequenced the whole genomes of 4,280 patients at low coverage and compared them to 3,652 previously sequenced population contr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96812a84e483206bb44513c008c312c5
Autor:
De Lange, KM, Moutsianas, L, Lee, JC, Lamb, CA, Luo, Y, Kennedy, NA, Jostins, L, Rice, DL, Gutierrez-Achury, J, Ji, S-G, Heap, G, Nimmo, ER, Edwards, C, Henderson, P, Mowat, C, Sanderson, J, Satsangi, J, Simmons, A, Wilson, DC, Tremelling, M, Hart, A, Mathew, CG, Newman, WG, Parkes, M, Lees, CW, Uhlig, H, Hawkey, C, Prescott, NJ, Ahmad, T, Mansfield, JC, Anderson, CA, Barrett, JC
Genetic association studies have identified 215 risk loci for inflammatory bowel disease, thereby uncovering fundamental aspects of its molecular biology. We performed a genome-wide association study of 25,305 individuals and conducted a meta-analysi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dc5647dd9b1c25851c7aa77c79499a35
Autor:
Onoufriadis A; Department of Medical and Molecular Genetics, King's College London, London, UK., Stone K; Department of Medical and Molecular Genetics, King's College London, London, UK., Katsiamides A; Department of Medical and Molecular Genetics, King's College London, London, UK., Amar A; Department of Medical and Molecular Genetics, King's College London, London, UK., Omar Y; Department of Medical and Molecular Genetics, King's College London, London, UK., de Lange KM; Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK., Taylor K; Department of Medical and Molecular Genetics, King's College London, London, UK., Barrett JC; Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK., Pollok R; Department Gastroenterology and Hepatology, St George's University Hospitals NHS Foundation Trust, London, UK., Hayee B; IBD Service, King's College Hospital NHS Foundation Trust, London, UK., Mansfield JC; Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, UK., Sanderson JD; Department of Gastroenterology, Guy's and St Thomas' NHS Foundation Trust, London, UK., Simpson MA; Department of Medical and Molecular Genetics, King's College London, London, UK., Mathew CG; Department of Medical and Molecular Genetics, King's College London, London, UK.; Sydney Brenner Institute for Molecular Bioscience, University of Witwatersrand, Johannesburg, South Africa., Prescott NJ; Department of Medical and Molecular Genetics, King's College London, London, UK.
Publikováno v:
Journal of Crohn's & colitis [J Crohns Colitis] 2018 Feb 28; Vol. 12 (3), pp. 321-326.
Autor:
Evans GL; Maurice Wilkins Centre for Molecular Biodiscovery and School of Biological Sciences, University of Auckland, 3A Symonds Street, Auckland 1142, New Zealand; School of Biological Sciences, University of Auckland, 3 Symonds Street, Auckland 1142, New Zealand. Electronic address: g.evans@auckland.ac.nz., Furkert DP; Maurice Wilkins Centre for Molecular Biodiscovery and School of Biological Sciences, University of Auckland, 3A Symonds Street, Auckland 1142, New Zealand; School of Chemical Sciences, University of Auckland, 23 Symonds Street, Auckland 1142, New Zealand., Abermil N; Maurice Wilkins Centre for Molecular Biodiscovery and School of Biological Sciences, University of Auckland, 3A Symonds Street, Auckland 1142, New Zealand; School of Chemical Sciences, University of Auckland, 23 Symonds Street, Auckland 1142, New Zealand., Kundu P; Maurice Wilkins Centre for Molecular Biodiscovery and School of Biological Sciences, University of Auckland, 3A Symonds Street, Auckland 1142, New Zealand; Biomolecular Interaction Centre, University of Canterbury, P. O. Box 4800, Christchurch 8140, New Zealand; Department of Chemistry, University of Canterbury, P. O. Box 4800, Christchurch 8140, New Zealand., de Lange KM; Maurice Wilkins Centre for Molecular Biodiscovery and School of Biological Sciences, University of Auckland, 3A Symonds Street, Auckland 1142, New Zealand; School of Biological Sciences, University of Auckland, 3 Symonds Street, Auckland 1142, New Zealand., Parker EJ; Maurice Wilkins Centre for Molecular Biodiscovery and School of Biological Sciences, University of Auckland, 3A Symonds Street, Auckland 1142, New Zealand; Biomolecular Interaction Centre, University of Canterbury, P. O. Box 4800, Christchurch 8140, New Zealand; Department of Chemistry, University of Canterbury, P. O. Box 4800, Christchurch 8140, New Zealand., Brimble MA; Maurice Wilkins Centre for Molecular Biodiscovery and School of Biological Sciences, University of Auckland, 3A Symonds Street, Auckland 1142, New Zealand; School of Chemical Sciences, University of Auckland, 23 Symonds Street, Auckland 1142, New Zealand., Baker EN; Maurice Wilkins Centre for Molecular Biodiscovery and School of Biological Sciences, University of Auckland, 3A Symonds Street, Auckland 1142, New Zealand; School of Biological Sciences, University of Auckland, 3 Symonds Street, Auckland 1142, New Zealand., Lott JS; Maurice Wilkins Centre for Molecular Biodiscovery and School of Biological Sciences, University of Auckland, 3A Symonds Street, Auckland 1142, New Zealand; School of Biological Sciences, University of Auckland, 3 Symonds Street, Auckland 1142, New Zealand. Electronic address: s.lott@auckland.ac.nz.
Publikováno v:
Biochimica et biophysica acta. Proteins and proteomics [Biochim Biophys Acta Proteins Proteom] 2018 Feb; Vol. 1866 (2), pp. 264-274. Date of Electronic Publication: 2017 Aug 26.
Autor:
Evans GL; Maurice Wilkins Centre for Molecular Biodiscovery and School of Biological Sciences, University of Auckland, 3 Symonds Street, Auckland 1142, New Zealand., Furkert DP; Maurice Wilkins Centre for Molecular Biodiscovery and School of Chemical Sciences, University of Auckland, 23 Symonds Street, Auckland 1142, New Zealand., Abermil N; Maurice Wilkins Centre for Molecular Biodiscovery and School of Chemical Sciences, University of Auckland, 23 Symonds Street, Auckland 1142, New Zealand., Kundu P; Maurice Wilkins Centre for Molecular Biodiscovery, Biomolecular Interaction Centre and Department of Chemistry, University of Canterbury, P.O. Box 4800, Christchurch 8140, New Zealand., de Lange KM; Maurice Wilkins Centre for Molecular Biodiscovery and School of Biological Sciences, University of Auckland, 3 Symonds Street, Auckland 1142, New Zealand., Parker EJ; Maurice Wilkins Centre for Molecular Biodiscovery, Biomolecular Interaction Centre and Department of Chemistry, University of Canterbury, P.O. Box 4800, Christchurch 8140, New Zealand., Brimble MA; Maurice Wilkins Centre for Molecular Biodiscovery and School of Chemical Sciences, University of Auckland, 23 Symonds Street, Auckland 1142, New Zealand., Baker EN; Maurice Wilkins Centre for Molecular Biodiscovery and School of Biological Sciences, University of Auckland, 3 Symonds Street, Auckland 1142, New Zealand., Lott JS; Maurice Wilkins Centre for Molecular Biodiscovery and School of Biological Sciences, University of Auckland, 3 Symonds Street, Auckland 1142, New Zealand.
Publikováno v:
Data in brief [Data Brief] 2017 Oct 31; Vol. 15, pp. 1019-1029. Date of Electronic Publication: 2017 Oct 31 (Print Publication: 2017).
Autor:
de Lange KM; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK., Moutsianas L; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK., Lee JC; Inflammatory Bowel Disease Research Group, Addenbrooke's Hospital, Cambridge, UK., Lamb CA; Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne., Luo Y; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK.; Division of Genetics and Rheumatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA., Kennedy NA; Precision Medicine Exeter, University of Exeter, Exeter, UK.; IBD Pharmacogenetics, Royal Devon and Exeter Foundation Trust, Exeter, UK., Jostins L; Wellcome Trust Centre for Human Genetics, University of Oxford, Headington, UK.; Christ Church, University of Oxford, St Aldates, UK., Rice DL; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK., Gutierrez-Achury J; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK., Ji SG; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK., Heap G; Precision Medicine Exeter, University of Exeter, Exeter, UK.; IBD Pharmacogenetics, Royal Devon and Exeter Foundation Trust, Exeter, UK., Nimmo ER; Gastrointestinal Unit, Wester General Hospital University of Edinburgh, Edinburgh, UK., Edwards C; Department of Gastroenterology, Torbay Hospital, Torbay, Devon, UK., Henderson P; Department of Child Life and Health, University of Edinburgh, Edinburgh, UK.; Department of Paediatric Gastroenterology and Nutrition, Royal Hospital for Sick Children,Edinburgh, UK., Mowat C; Department of Medicine, Ninewells Hospital and Medical School, Dundee, UK., Sanderson J; Guy's & St Thomas' NHS Foundation Trust, St Thomas' Hospital, Department of Gastroenterology, London, UK., Satsangi J; Gastrointestinal Unit, Wester General Hospital University of Edinburgh, Edinburgh, UK., Simmons A; Translational Gastroenterology Unit, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DS, UK.; Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK., Wilson DC; Paediatric Gastroenterology and Nutrition, Royal Hospital for Sick Children, Edinburgh, UK.; Child Life and Health, University of Edinburgh, Edinburgh, Scotland, UK., Tremelling M; Gastroenterology & General Medicine, Norfolk and Norwich University Hospital, Norwich, UK., Hart A; Department of Medicine, St Mark's Hospital, Harrow, Middlesex, UK., Mathew CG; Department of Medical and Molecular Genetics, Faculty of Life Science and Medicine, King's College London, Guy's Hospital, London, UK.; Sydney Brenner Institute for Molecular Bioscience, Faculty of Health Sciences, University of Witwatersrand, South Africa., Newman WG; Genetic Medicine, Manchester Academic Health Science Centre, Manchester, UK.; The Manchester Centre for Genomic Medicine, University of Manchester, Manchester, UK., Parkes M; Inflammatory Bowel Disease Research Group, Addenbrooke's Hospital, Cambridge, UK., Lees CW; Gastrointestinal Unit, Wester General Hospital University of Edinburgh, Edinburgh, UK., Uhlig H; Translational Gastroenterology Unit and the Department of Paediatrics, University of Oxford, Oxford, United Kingdom., Hawkey C; Nottingham Digestive Diseases Centre, Queens Medical Centre, Nottingham, UK., Prescott NJ; Department of Medical and Molecular Genetics, Faculty of Life Science and Medicine, King's College London, Guy's Hospital, London, UK., Ahmad T; Precision Medicine Exeter, University of Exeter, Exeter, UK.; IBD Pharmacogenetics, Royal Devon and Exeter Foundation Trust, Exeter, UK., Mansfield JC; Institute of Human Genetics, Newcastle University, Newcastle upon Tyne, UK., Anderson CA; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK., Barrett JC; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK.
Publikováno v:
Nature genetics [Nat Genet] 2017 Feb; Vol. 49 (2), pp. 256-261. Date of Electronic Publication: 2017 Jan 09.
Autor:
Luo Y; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK.; Division of Genetics and Rheumatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA., de Lange KM; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK., Jostins L; Wellcome Trust Centre for Human Genetics, University of Oxford, Headington, UK.; Christ Church, University of Oxford, St Aldates, UK., Moutsianas L; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK., Randall J; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK., Kennedy NA; Precision Medicine Exeter, University of Exeter, Exeter, UK.; IBD Pharmacogenetics, Royal Devon and Exeter Foundation Trust, Exeter, UK., Lamb CA; Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne., McCarthy S; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK., Ahmad T; Precision Medicine Exeter, University of Exeter, Exeter, UK.; IBD Pharmacogenetics, Royal Devon and Exeter Foundation Trust, Exeter, UK., Edwards C; Department of Gastroenterology, Torbay Hospital, Torbay, Devon, UK., Serra EG; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK., Hart A; Department of Medicine, St Mark's Hospital, Harrow, Middlesex, UK., Hawkey C; Nottingham Digestive Diseases Centre, Queens Medical Centre, Nottingham, UK., Mansfield JC; Institute of Human Genetics, Newcastle University, Newcastle upon Tyne, UK., Mowat C; Department of Medicine, Ninewells Hospital and Medical School, Dundee, UK., Newman WG; Genetic Medicine, Manchester Academic Health Science Centre, Manchester, UK.; The Manchester Centre for Genomic Medicine, University of Manchester, Manchester, UK., Nichols S; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK., Pollard M; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK., Satsangi J; Gastrointestinal Unit, Wester General Hospital University of Edinburgh, Edinburgh, UK., Simmons A; Translational Gastroenterology Unit, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DS, UK.; Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK., Tremelling M; Gastroenterology & General Medicine, Norfolk and Norwich University Hospital, Norwich, UK., Uhlig H; Translational Gastroenterology Unit and the Department of Paediatrics, University of Oxford, Oxford, United Kingdom., Wilson DC; Paediatric Gastroenterology and Nutrition, Royal Hospital for Sick Children, Edinburgh, UK.; Child Life and Health, University of Edinburgh, Edinburgh, Scotland, UK., Lee JC; Inflammatory Bowel Disease Research Group, Addenbrooke's Hospital, Cambridge, UK., Prescott NJ; Department of Medical and Molecular Genetics, Faculty of Life Science and Medicine, King's College London, Guy's Hospital, London, UK., Lees CW; Gastrointestinal Unit, Wester General Hospital University of Edinburgh, Edinburgh, UK., Mathew CG; Department of Medical and Molecular Genetics, Faculty of Life Science and Medicine, King's College London, Guy's Hospital, London, UK.; Sydney Brenner Institute for Molecular Bioscience, Faculty of Health Sciences, University of Witwatersrand, South Africa., Parkes M; Inflammatory Bowel Disease Research Group, Addenbrooke's Hospital, Cambridge, UK., Barrett JC; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK., Anderson CA; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK.
Publikováno v:
Nature genetics [Nat Genet] 2017 Feb; Vol. 49 (2), pp. 186-192. Date of Electronic Publication: 2017 Jan 09.
Autor:
Salmon SR; School of Science, Faculty of Science and Engineering, University of Waikato , Private Bag 3105, Hamilton, New Zealand., de Lange KM; School of Science, Faculty of Science and Engineering, University of Waikato , Private Bag 3105, Hamilton, New Zealand., Lane JR; School of Science, Faculty of Science and Engineering, University of Waikato , Private Bag 3105, Hamilton, New Zealand.
Publikováno v:
The journal of physical chemistry. A [J Phys Chem A] 2016 Apr 07; Vol. 120 (13), pp. 2096-105. Date of Electronic Publication: 2016 Mar 23.
Autor:
de Lange KM; Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1HH, United Kingdom., Barrett JC; Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1HH, United Kingdom; European Molecular Biology Laboratory European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridge CB10 1HH, United Kingdom; Centre for Therapeutic Target Validation, Wellcome Genome Campus, Hinxton, Cambridge CB10 1HH, United Kingdom. Electronic address: jb26@sanger.ac.uk.
Publikováno v:
Journal of autoimmunity [J Autoimmun] 2015 Nov; Vol. 64, pp. 91-100. Date of Electronic Publication: 2015 Aug 07.
Autor:
de Lange KM; Department of Chemistry, University of Waikato, Private Bag 3105, Hamilton 3240, New Zealand., Lane JR
Publikováno v:
The Journal of chemical physics [J Chem Phys] 2011 Aug 14; Vol. 135 (6), pp. 064304.