Jaw Bone Invasion of Oral Squamous Cell Carcinoma Is Associated with Osteoclast Count and Expression of Its Regulating Proteins in Patients and Organoids.

Autor: de Kort, Willem W. B.^1,2 (AUTHOR) r.j.j.vanes@umcutrecht.nl, Haakma, Wisse E.¹ (AUTHOR), van Es, Robert J. J.^2,3 (AUTHOR) d.gawlitta@umcutrecht.nl, Gawlitta, Debby² (AUTHOR), Driehuis, Else⁴ (AUTHOR) else.driehuis@xilis.nl, Gansevoort, Merel¹ (AUTHOR), Willems, Stefan M.⁵ (AUTHOR) s.m.willems@umcg.nl

Publikováno v: Journal of Clinical Medicine. Sep2023, Vol. 12 Issue 18, p6035. 14p.

Patient-derived head and neck cancer organoids allow treatment stratification and serve as a tool for biomarker validation and identification.

Autor: Millen R; Oncode Institute, Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW), Utrecht, the Netherlands. Electronic address: rosie.millen@roche.com., De Kort WWB; Department of Oral and Maxillofacial Surgery, University Medical Center Utrecht, Utrecht, the Netherlands; Department of Pathology, University Medical Center Utrecht, Utrecht, the Netherlands., Koomen M; Oncode Institute, Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW), Utrecht, the Netherlands., van Son GJF; Oncode Institute, Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW), Utrecht, the Netherlands; Princess Maxima Center, Utrecht, the Netherlands., Gobits R; Oncode Institute, Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW), Utrecht, the Netherlands., Penning de Vries B; Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Centre Utrecht, Utrecht University, Utrecht, the Netherlands., Begthel H; Oncode Institute, Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW), Utrecht, the Netherlands., Zandvliet M; Department of Clinical Sciences - Companion Animals, Faculty of Veterinary Medicine, Utrecht University, Utrecht, the Netherlands., Doornaert P; Department of Radiotherapy, University Medical Center Utrecht, Utrecht, the Netherlands., Raaijmakers CPJ; Department of Radiotherapy, University Medical Center Utrecht, Utrecht, the Netherlands., Geurts MH; Oncode Institute, Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW), Utrecht, the Netherlands., Elias SG; Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Centre Utrecht, Utrecht University, Utrecht, the Netherlands., van Es RJJ; Department of Oral and Maxillofacial Surgery, University Medical Center Utrecht, Utrecht, the Netherlands; Department of Head and Neck Surgical Oncology, University Medical Center Utrecht, Utrecht, the Netherlands., de Bree R; Department of Head and Neck Surgical Oncology, University Medical Center Utrecht, Utrecht, the Netherlands., Devriese LA; Department of Medical Oncology, University Medical Center Utrecht, Utrecht, the Netherlands., Willems SM; Department of Pathology, University Medical Center Utrecht, Utrecht, the Netherlands; Department of Pathology, University Medical Center Groningen, Groningen, the Netherlands., Kranenburg O; Utrecht Platform for Organoid Technology (U-PORT), Utrecht Medical Center Utrecht, Utrecht, the Netherlands., Driehuis E; Oncode Institute, Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW), Utrecht, the Netherlands. Electronic address: else.driehuis@xilis.nl., Clevers H; Oncode Institute, Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW), Utrecht, the Netherlands. Electronic address: h.clevers@hubrecht.eu.

Publikováno v: Med (New York, N.Y.) [Med] 2023 May 12; Vol. 4 (5), pp. 290-310.e12.