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Amino acid synthesis deficiencies

Autor: de Koning, T. J.

Publikováno v: Journal of Inherited Metabolic Disease

In recent years the number of disorders known to affect amino acid synthesis has grown rapidly. Nor is it just the number of disorders that has increased: the associated clinical phenotypes have also expanded spectacularly, primarily due to the advan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47cdf2d588a74f6aafb1c0cb685b7af5
https://doi.org/10.1007/s10545-017-0063-1

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Detecting intratumoral heterogeneity of EGFR activity by liposome-based in vivo transfection of a fluorescent biosensor

Autor: Weitsman, G, Mitchell, NJ, Evans, R, Cheung, A, Kalber, TL, Bofinger, R, Fruhwirth, GO, Keppler, M, Wright, ZVF, Barber, PR, Gordon, P, de Koning, T, Wulaningsih, W, Sander, K, Vojnovic, B, Ameer-Beg, S, Lythgoe, M, Arnold, JN, Årstad, E, Festy, F, Hailes, HC, Tabor, AB, Ng, T

Publikováno v: Oncogene
Weitsman, G, Mitchell, N J, Evans, R, Cheung, A, Kalber, T L, Bofinger, R, Fruhwirth, G O, Keppler, M, Wright, Z V F, Barber, P R, Gordon, P, de Koning, T, Wulaningsih, W, Sander, K, Vojnovic, B, Ameer-Beg, S, Lythgoe, M, Arnold, J N, Årstad, E, Festy, F, Hailes, H C, Tabor, A B & Ng, T 2017, ' Detecting intratumoral heterogeneity of EGFR activity by liposome-based in vivo transfection of a fluorescent biosensor ', Oncogene, vol. 36, no. 25, pp. 3618–3628 . https://doi.org/10.1038/onc.2016.522

Despite decades of research in the epidermal growth factor receptor (EGFR) signalling field, and many targeted anti-cancer drugs that have been tested clinically, the success rate for these agents in the clinic is low, particularly in terms of the im

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::858fc396aef7cd23f52cb66d129a5f5a
http://ora.ox.ac.uk/objects/uuid:

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