Výsledky vyhledávání - "de Jonge, M. J. (Maja J. A.)"

Systemic blockade of clever-1 elicits lymphocyte activation alongside checkpoint molecule downregulation in patients with solid tumors:results from a phase I/II clinical trial

Autor: Virtakoivu, R. (Reetta), Rannikko, J. H. (Jenna H.), Viitala, M. (Miro), Vaura, F. (Felix), Takeda, A. (Akira), Lönnberg, T. (Tapio), Koivunen, J. (Jussi), Jaakkola, P. (Panu), Pasanen, A. (Annika), Shetty, S. (Shishir), de Jonge, M. J. (Maja J. A.), Robbrecht, D. (Debbie), Ma, Y. T. (Yuk Ting), Skyttä, T. (Tanja), Minchom, A. (Anna), Jalkanen, S. (Sirpa), Karvonen, M. K. (Matti K.), Mandelin, J. (Jami), Bono, P. (Petri), Hollmén, M. (Maija)

Purpose:: Macrophages are critical in driving an immunosuppressive tumor microenvironment that counteracts the efficacy of T-cell–targeting therapies. Thus, agents able to reprogram macrophages toward a proinflammatory state hold promise as novel i

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