Inhibition of arterivirus RNA synthesis by cyclophilin inhibitors is counteracted by mutations in replicase transmembrane subunits

Autor: Clara C. Posthuma, Boomaars-van der Zanden Al, de Wilde Ah, Montserrat Bárcena, Eric J. Snijder, de Jong Awm

Previously, the cyclophilin inhibitors cyclosporin A (CsA) and Alisporivir (ALV) were shown to inhibit the replication of diverse RNA viruses, including arteriviruses and coronaviruses, which both belong to the orderNidovirales. Here we aimed to iden

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https://doi.org/10.1101/587261

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Human VAPome Analysis Reveals MOSPD1 and MOSPD3 as Membrane Contact Site Proteins Interacting with FFAT-Related FFNT Motifs.

Autor: Cabukusta B, Berlin I, van Elsland DM, Forkink I, Spits M, de Jong AWM, Akkermans JJLL, Wijdeven RHM, Janssen GMC, van Veelen PA, Neefjes J

Publikováno v: Cell reports [Cell Rep] 2023 Jul 25; Vol. 42 (7), pp. 112849. Date of Electronic Publication: 2023 Jul 12.

A molecular pore spans the double membrane of the coronavirus replication organelle.

Autor: Wolff G; Section Electron Microscopy, Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden 2333 ZC, Netherlands., Limpens RWAL; Section Electron Microscopy, Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden 2333 ZC, Netherlands., Zevenhoven-Dobbe JC; Molecular Virology Laboratory, Department of Medical Microbiology, Leiden University Medical Center, Leiden 2333 ZA, Netherlands., Laugks U; Department of Structural Cell Biology of Viruses, Centre for Structural Systems Biology, Heinrich Pette Institute, Leibnitz Institute of Experimental Virology, 22607 Hamburg, Germany., Zheng S; Howard Hughes Medical Institute, Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA 94143, USA., de Jong AWM; Section Electron Microscopy, Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden 2333 ZC, Netherlands., Koning RI; Section Electron Microscopy, Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden 2333 ZC, Netherlands., Agard DA; Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA 94143, USA., Grünewald K; Department of Structural Cell Biology of Viruses, Centre for Structural Systems Biology, Heinrich Pette Institute, Leibnitz Institute of Experimental Virology, 22607 Hamburg, Germany.; Department of Chemistry, MIN Faculty, Universität Hamburg, 20146 Hamburg, Germany., Koster AJ; Section Electron Microscopy, Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden 2333 ZC, Netherlands., Snijder EJ; Molecular Virology Laboratory, Department of Medical Microbiology, Leiden University Medical Center, Leiden 2333 ZA, Netherlands., Bárcena M; Section Electron Microscopy, Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden 2333 ZC, Netherlands. m.barcena@lumc.nl.

Publikováno v: Science (New York, N.Y.) [Science] 2020 Sep 11; Vol. 369 (6509), pp. 1395-1398. Date of Electronic Publication: 2020 Aug 06.

Adaptive Mutations in Replicase Transmembrane Subunits Can Counteract Inhibition of Equine Arteritis Virus RNA Synthesis by Cyclophilin Inhibitors.

Autor: de Wilde AH; Molecular Virology Laboratory, Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands., Boomaars-van der Zanden AL; Molecular Virology Laboratory, Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands., de Jong AWM; Section Electron Microscopy, Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden, The Netherlands., Bárcena M; Section Electron Microscopy, Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden, The Netherlands., Snijder EJ; Molecular Virology Laboratory, Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands e.j.snijder@lumc.nl., Posthuma CC; Molecular Virology Laboratory, Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands.

Publikováno v: Journal of virology [J Virol] 2019 Aug 28; Vol. 93 (18). Date of Electronic Publication: 2019 Aug 28 (Print Publication: 2019).