Thiophenecarboxamide Derivatives Activated by EthA Kill Mycobacterium tuberculosis by Inhibiting the CTP Synthetase PyrG

Autor: Mori, Giorgia, Chiarelli, Laurent R., Esposito, Marta, Makarov, Vadim, Bellinzoni, Marco, Hartkoorn, Ruben C., Degiacomi, Giulia, Boldrin, Francesca, Ekins, Sean, de Jesus Lopes Ribeiro, Ana Luisa, Marino, Leonardo B., Centárová, Ivana, Svetlíková, Zuzana, Blaško, Jaroslav, Kazakova, Elena, Lepioshkin, Alexander, Barilone, Nathalie, Zanoni, Giuseppe, Porta, Alessio, Fondi, Marco, Fani, Renato, Baulard, Alain R., Mikušová, Katarína, Alzari, Pedro M., Manganelli, Riccardo, de Carvalho, Luiz Pedro S., Riccardi, Giovanna, Cole, Stewart T., Pasca, Maria Rosalia

Publikováno v: In Chemistry & Biology 23 July 2015 22(7):917-927

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Biological and structural characterization of the Mycobacterium smegmatis nitroreductase NfnB, and its role in benzothiazinone resistance

Autor: Manina, Giulia, Bellinzoni, Marco, Pasca, Maria Rosalia, Neres, João, Milano, Anna, de Jesus Lopes Ribeiro, Ana Luisa, Buroni, Silvia, Skovierová, Henrieta, Dianišková, Petronela, Mikušová, Katarína, Marák, Jozef, Makarov, Vadim, Giganti, David, Haouz, Ahmed, Lucarelli, Anna Paola, Degiacomi, Giulia, Piazza, Aurora, Chiarelli, Laurent R, De Rossi, Edda, Salina, Elena, Cole, Stewart T, Alzari, Pedro M, Riccardi, Giovanna

Publikováno v: Molecular Microbiology
Molecular Microbiology, 2010, 77 (5), pp.1172-1185. ⟨10.1111/j.1365-2958.2010.07277.x⟩
Molecular Microbiology, Wiley, 2010, 77 (5), pp.1172-1185. ⟨10.1111/j.1365-2958.2010.07277.x⟩

International audience; Tuberculosis is still a leading cause of death in developing countries, for which there is an urgent need for new pharmacological agents. The synthesis of the novel antimycobacterial drug class of benzothiazinones (BTZs) and t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::6b8da9c02040ff76f2335f2bccbbcd20
https://hal-pasteur.archives-ouvertes.fr/pasteur-03137947

2-Carboxyquinoxalines kill mycobacterium tuberculosis through noncovalent inhibition of DprE1.

Autor: Neres J; †More Medicines for Tuberculosis (MM4TB) Consortium (www.mm4tb.org).; ‡Global Health Institute, Ecole Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland., Hartkoorn RC; †More Medicines for Tuberculosis (MM4TB) Consortium (www.mm4tb.org).; ‡Global Health Institute, Ecole Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland., Chiarelli LR; †More Medicines for Tuberculosis (MM4TB) Consortium (www.mm4tb.org).; §Department of Biology and Biotecnology 'Lazzaro Spallanzani', University of Pavia, 27100 Pavia, Italy., Gadupudi R; ∥Tydock Pharma, srl Via Campi 183, 41125 Modena, Italy.; ⊥Department of Life Sciences, University of Modena and Reggio Emilia, Via Campi 183, 41126 Modena, Italy., Pasca MR; †More Medicines for Tuberculosis (MM4TB) Consortium (www.mm4tb.org).; §Department of Biology and Biotecnology 'Lazzaro Spallanzani', University of Pavia, 27100 Pavia, Italy., Mori G; †More Medicines for Tuberculosis (MM4TB) Consortium (www.mm4tb.org).; §Department of Biology and Biotecnology 'Lazzaro Spallanzani', University of Pavia, 27100 Pavia, Italy., Venturelli A; ∥Tydock Pharma, srl Via Campi 183, 41125 Modena, Italy., Savina S; †More Medicines for Tuberculosis (MM4TB) Consortium (www.mm4tb.org).; #A. N. Bakh Institute of Biochemistry, Russian Academy of Science, 119071 Moscow, Russia., Makarov V; †More Medicines for Tuberculosis (MM4TB) Consortium (www.mm4tb.org).; #A. N. Bakh Institute of Biochemistry, Russian Academy of Science, 119071 Moscow, Russia., Kolly GS; †More Medicines for Tuberculosis (MM4TB) Consortium (www.mm4tb.org).; ‡Global Health Institute, Ecole Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland., Molteni E; †More Medicines for Tuberculosis (MM4TB) Consortium (www.mm4tb.org).; §Department of Biology and Biotecnology 'Lazzaro Spallanzani', University of Pavia, 27100 Pavia, Italy., Binda C; †More Medicines for Tuberculosis (MM4TB) Consortium (www.mm4tb.org).; §Department of Biology and Biotecnology 'Lazzaro Spallanzani', University of Pavia, 27100 Pavia, Italy., Dhar N; †More Medicines for Tuberculosis (MM4TB) Consortium (www.mm4tb.org).; ‡Global Health Institute, Ecole Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland., Ferrari S; ∥Tydock Pharma, srl Via Campi 183, 41125 Modena, Italy.; ⊥Department of Life Sciences, University of Modena and Reggio Emilia, Via Campi 183, 41126 Modena, Italy., Brodin P; †More Medicines for Tuberculosis (MM4TB) Consortium (www.mm4tb.org).; ∇Inserm U1019 - CNRS UMR 8204, Institut Pasteur de Lille, Université de Lille, 1 rue du Professeur Calmette, 59019, Lille, France., Delorme V; †More Medicines for Tuberculosis (MM4TB) Consortium (www.mm4tb.org).; ∇Inserm U1019 - CNRS UMR 8204, Institut Pasteur de Lille, Université de Lille, 1 rue du Professeur Calmette, 59019, Lille, France., Landry V; ∇Inserm U1019 - CNRS UMR 8204, Institut Pasteur de Lille, Université de Lille, 1 rue du Professeur Calmette, 59019, Lille, France., de Jesus Lopes Ribeiro AL; §Department of Biology and Biotecnology 'Lazzaro Spallanzani', University of Pavia, 27100 Pavia, Italy., Farina D; ⊥Department of Life Sciences, University of Modena and Reggio Emilia, Via Campi 183, 41126 Modena, Italy., Saxena P; ⊥Department of Life Sciences, University of Modena and Reggio Emilia, Via Campi 183, 41126 Modena, Italy., Pojer F; †More Medicines for Tuberculosis (MM4TB) Consortium (www.mm4tb.org).; ‡Global Health Institute, Ecole Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland., Carta A; ○Department of Chemistry and Pharmacy, University of Sassari, 07100 Sassari, Italy., Luciani R; ⊥Department of Life Sciences, University of Modena and Reggio Emilia, Via Campi 183, 41126 Modena, Italy., Porta A; ◆Department of Chemistry, University of Pavia, 27100 Pavia, Italy., Zanoni G; ◆Department of Chemistry, University of Pavia, 27100 Pavia, Italy., De Rossi E; †More Medicines for Tuberculosis (MM4TB) Consortium (www.mm4tb.org).; §Department of Biology and Biotecnology 'Lazzaro Spallanzani', University of Pavia, 27100 Pavia, Italy., Costi MP; †More Medicines for Tuberculosis (MM4TB) Consortium (www.mm4tb.org).; ∥Tydock Pharma, srl Via Campi 183, 41125 Modena, Italy.; ⊥Department of Life Sciences, University of Modena and Reggio Emilia, Via Campi 183, 41126 Modena, Italy., Riccardi G; †More Medicines for Tuberculosis (MM4TB) Consortium (www.mm4tb.org).; §Department of Biology and Biotecnology 'Lazzaro Spallanzani', University of Pavia, 27100 Pavia, Italy., Cole ST; †More Medicines for Tuberculosis (MM4TB) Consortium (www.mm4tb.org).; ‡Global Health Institute, Ecole Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland.

Publikováno v: ACS chemical biology [ACS Chem Biol] 2015 Mar 20; Vol. 10 (3), pp. 705-14. Date of Electronic Publication: 2014 Dec 09.

Evaluation of fluoroquinolone resistance mechanisms in Pseudomonas aeruginosa multidrug resistance clinical isolates.

Autor: Pasca MR; Department of Genetics and Microbiology, University of Pavia, Pavia, Italy. mariarosalia.pasca@unipv.it, Dalla Valle C, De Jesus Lopes Ribeiro AL, Buroni S, Papaleo MC, Bazzini S, Udine C, Incandela ML, Daffara S, Fani R, Riccardi G, Marone P

Publikováno v: Microbial drug resistance (Larchmont, N.Y.) [Microb Drug Resist] 2012 Feb; Vol. 18 (1), pp. 23-32. Date of Electronic Publication: 2011 Jul 28.