Dietary delivery of glycomacropeptide within the whey protein matrix is not effective in mitigating tissue ceramide deposition and obesity in mice fed a high-fat diet.

Autor: de Hart NMMP; Department of Nutrition and Integrative Physiology, University of Utah, Salt Lake City, UT 84112., Petrocelli JJ; Department of Physical Therapy and Athletic Training, University of Utah, Salt Lake City, UT 84108., Nicholson RJ; Department of Nutrition and Integrative Physiology, University of Utah, Salt Lake City, UT 84112., Yee EM; Department of Physical Therapy and Athletic Training, University of Utah, Salt Lake City, UT 84108., van Onselen L; Department of Physical Therapy and Athletic Training, University of Utah, Salt Lake City, UT 84108., Lang MJ; Department of Nutrition and Integrative Physiology, University of Utah, Salt Lake City, UT 84112., Bourrant PE; Department of Nutrition and Integrative Physiology, University of Utah, Salt Lake City, UT 84112., Ferrara PJ; Department of Nutrition and Integrative Physiology, University of Utah, Salt Lake City, UT 84112., Bastian ED; Dairy West Innovation Partnerships, Twin Falls, ID 83301., Ward LS; Glanbia Nutritionals Research, Twin Falls, ID 83301., Petersen BL; Glanbia Nutritionals Research, Twin Falls, ID 83301., Drummond MJ; Department of Nutrition and Integrative Physiology, University of Utah, Salt Lake City, UT 84112; Department of Physical Therapy and Athletic Training, University of Utah, Salt Lake City, UT 84108. Electronic address: micah.drummond@hsc.utah.edu.

Publikováno v: Journal of dairy science [J Dairy Sci] 2024 Feb; Vol. 107 (2), pp. 669-682. Date of Electronic Publication: 2023 Sep 13.

Disuse-induced muscle fibrosis, cellular senescence, and senescence-associated secretory phenotype in older adults are alleviated during re-ambulation with metformin pre-treatment.

Autor: Petrocelli JJ; Department of Physical Therapy and Athletic Training, University of Utah, Salt Lake City, Utah, USA., McKenzie AI; Department of Physical Therapy and Athletic Training, University of Utah, Salt Lake City, Utah, USA., de Hart NMMP; Department of Nutrition and Integrative Physiology, University of Utah, Salt Lake City, Utah, USA., Reidy PT; Department of Kinesiology, Nutrition, and Health, Miami University, Oxford, Ohio, USA., Mahmassani ZS; Molecular Medicine Program, University of Utah, Salt Lake City, Utah, USA., Keeble AR; Center for Muscle Biology, University of Kentucky, Lexington, Kentucky, USA., Kaput KL; Department of Internal Medicine, University of Utah, Salt Lake City, Utah, USA., Wahl MP; Department of Internal Medicine, University of Utah, Salt Lake City, Utah, USA., Rondina MT; Molecular Medicine Program, University of Utah, Salt Lake City, Utah, USA.; Department of Internal Medicine, University of Utah, Salt Lake City, Utah, USA., Marcus RL; Department of Physical Therapy and Athletic Training, University of Utah, Salt Lake City, Utah, USA., Welt CK; Department of Internal Medicine, University of Utah, Salt Lake City, Utah, USA., Holland WL; Department of Nutrition and Integrative Physiology, University of Utah, Salt Lake City, Utah, USA., Funai K; Department of Nutrition and Integrative Physiology, University of Utah, Salt Lake City, Utah, USA.; Molecular Medicine Program, University of Utah, Salt Lake City, Utah, USA., Fry CS; Center for Muscle Biology, University of Kentucky, Lexington, Kentucky, USA., Drummond MJ; Department of Physical Therapy and Athletic Training, University of Utah, Salt Lake City, Utah, USA.; Department of Nutrition and Integrative Physiology, University of Utah, Salt Lake City, Utah, USA.; Molecular Medicine Program, University of Utah, Salt Lake City, Utah, USA.

Publikováno v: Aging cell [Aging Cell] 2023 Nov; Vol. 22 (11), pp. e13936. Date of Electronic Publication: 2023 Jul 24.

Muscle disuse as hindlimb unloading in early postnatal mice negatively impacts grip strength in adult mice: a pilot study.

Autor: Reidy PT; Department of Kinesiology, Nutrition and Health, Miami University, Oxford, Ohio, United States., Smith AD; Department of Kinesiology, Nutrition and Health, Miami University, Oxford, Ohio, United States., Jevnikar BE; Department of Kinesiology, Nutrition and Health, Miami University, Oxford, Ohio, United States., Doctor AK; Department of Kinesiology, Nutrition and Health, Miami University, Oxford, Ohio, United States., Williams RW; Department of Kinesiology, Nutrition and Health, Miami University, Oxford, Ohio, United States., Kachulkin AA; Department of Kinesiology, Nutrition and Health, Miami University, Oxford, Ohio, United States., Monnig JM; Department of Kinesiology, Nutrition and Health, Miami University, Oxford, Ohio, United States., Fix DK; Department of Physical Therapy & Athletic Training, University of Utah, Salt Lake City, Utah, United States., Petrocelli JJ; Department of Physical Therapy & Athletic Training, University of Utah, Salt Lake City, Utah, United States., Mahmassani ZS; Department of Physical Therapy & Athletic Training, University of Utah, Salt Lake City, Utah, United States., McKenzie AI; Department of Internal Medicine, University of Utah, Salt Lake City, Utah, United States., de Hart NMMP; Department of Nutrition and Integrative Physiology, University of Utah, Salt Lake City, Utah, United States., Drummond MJ; Department of Physical Therapy & Athletic Training, University of Utah, Salt Lake City, Utah, United States.; Molecular Medicine Program, University of Utah, Salt Lake City, Utah, United States.

Publikováno v: Journal of applied physiology (Bethesda, Md. : 1985) [J Appl Physiol (1985)] 2023 Apr 01; Vol. 134 (4), pp. 787-798. Date of Electronic Publication: 2023 Feb 09.

Cellular senescence and disrupted proteostasis induced by myotube atrophy are prevented with low-dose metformin and leucine cocktail.

Autor: Petrocelli JJ; Department of Physical Therapy and Athletic, University of Utah, Salt Lake City, UT 84112, USA., de Hart NMMP; Department of Physical Therapy and Athletic, University of Utah, Salt Lake City, UT 84112, USA., Lang MJ; Department of Nutrition and Integrative Physiology, University of Utah, Salt Lake City, UT 84112, USA., Yee EM; Molecular Medicine Program, University of Utah, Salt Lake City, UT 84112, USA., Ferrara PJ; Molecular Medicine Program, University of Utah, Salt Lake City, UT 84112, USA., Fix DK; Molecular Medicine Program, University of Utah, Salt Lake City, UT 84112, USA., Chaix A; Department of Nutrition and Integrative Physiology, University of Utah, Salt Lake City, UT 84112, USA.; Molecular Medicine Program, University of Utah, Salt Lake City, UT 84112, USA., Funai K; Department of Physical Therapy and Athletic, University of Utah, Salt Lake City, UT 84112, USA.; Department of Nutrition and Integrative Physiology, University of Utah, Salt Lake City, UT 84112, USA.; Molecular Medicine Program, University of Utah, Salt Lake City, UT 84112, USA., Drummond MJ; Department of Physical Therapy and Athletic, University of Utah, Salt Lake City, UT 84112, USA.; Department of Nutrition and Integrative Physiology, University of Utah, Salt Lake City, UT 84112, USA.; Molecular Medicine Program, University of Utah, Salt Lake City, UT 84112, USA.

Publikováno v: Aging [Aging (Albany NY)] 2023 Mar 20; Vol. 15 (6), pp. 1808-1832. Date of Electronic Publication: 2023 Mar 20.

Short-term exposure to a clinical dose of metformin increases skeletal muscle mitochondrial H 2 O 2 emission and production in healthy, older adults: A randomized controlled trial.

Autor: McKenzie AI; Department of Physical Therapy and Athletic Training, University of Utah, 520 Wakara Way, Salt Lake City, UT 84108, USA; George E. Wahlen Department of Veterans Affairs Medical Center, Geriatric Research, Education, and Clinical Center, 500 Foothill Dr., Salt Lake City, UT 84148, USA., Mahmassani ZS; Department of Physical Therapy and Athletic Training, University of Utah, 520 Wakara Way, Salt Lake City, UT 84108, USA., Petrocelli JJ; Department of Physical Therapy and Athletic Training, University of Utah, 520 Wakara Way, Salt Lake City, UT 84108, USA., de Hart NMMP; Department of Nutrition and Integrative Physiology, University of Utah, 250 S 1850 E, Salt Lake City, UT 84112, USA., Fix DK; Department of Physical Therapy and Athletic Training, University of Utah, 520 Wakara Way, Salt Lake City, UT 84108, USA., Ferrara PJ; Department of Physical Therapy and Athletic Training, University of Utah, 520 Wakara Way, Salt Lake City, UT 84108, USA., LaStayo PC; Department of Physical Therapy and Athletic Training, University of Utah, 520 Wakara Way, Salt Lake City, UT 84108, USA., Marcus RL; Department of Physical Therapy and Athletic Training, University of Utah, 520 Wakara Way, Salt Lake City, UT 84108, USA., Rondina MT; Department of Internal Medicine & Molecular Medicine Program, University of Utah School of Medicine, Salt Lake City, UT, USA; George E. Wahlen Department of Veterans Affairs Medical Center, Geriatric Research, Education, and Clinical Center, 500 Foothill Dr., Salt Lake City, UT 84148, USA; Department of Pathology, University of Utah School of Medicine, Salt Lake City, UT, USA., Summers SA; Department of Nutrition and Integrative Physiology, University of Utah, 250 S 1850 E, Salt Lake City, UT 84112, USA., Johnson JM; Department of Nutrition and Integrative Physiology, University of Utah, 250 S 1850 E, Salt Lake City, UT 84112, USA., Trinity JD; Department of Nutrition and Integrative Physiology, University of Utah, 250 S 1850 E, Salt Lake City, UT 84112, USA; Department of Internal Medicine & Molecular Medicine Program, University of Utah School of Medicine, Salt Lake City, UT, USA; George E. Wahlen Department of Veterans Affairs Medical Center, Geriatric Research, Education, and Clinical Center, 500 Foothill Dr., Salt Lake City, UT 84148, USA., Funai K; Department of Physical Therapy and Athletic Training, University of Utah, 520 Wakara Way, Salt Lake City, UT 84108, USA; Department of Nutrition and Integrative Physiology, University of Utah, 250 S 1850 E, Salt Lake City, UT 84112, USA., Drummond MJ; Department of Physical Therapy and Athletic Training, University of Utah, 520 Wakara Way, Salt Lake City, UT 84108, USA; Department of Nutrition and Integrative Physiology, University of Utah, 250 S 1850 E, Salt Lake City, UT 84112, USA. Electronic address: micah.drummond@hsc.utah.edu.

Publikováno v: Experimental gerontology [Exp Gerontol] 2022 Jun 15; Vol. 163, pp. 111804. Date of Electronic Publication: 2022 Apr 09.