Zobrazeno 1 - 10
of 13
pro vyhledávání: '"de Gerald Haan"'
Publikováno v:
Leukemia. 27(3):523-533
The equilibrium between self-renewal and differentiation of hematopoietic stem cells is regulated by epigenetic mechanisms. In particular, Polycomb-group (PcG) proteins have been shown to be involved in this process by repressing genes involved in ce
Publikováno v:
Annals of the New York Academy of Sciences. 1266:138-150
Publikováno v:
Bone marrow transplantation, 38(12), 789-797. Nature Publishing Group
The role of very late antigen-5 (VLA-5) in homing and mobilization of hematopoietic stem cells from normal bone marrow (NBM) and bone marrow (MBM) and peripheral blood (MPB) from mobilized mice was investigated. We found a decreased number of VLA-5-e
Autor:
Todd E. Meyerrose, Barry Grimes, G Van Zant, de Gerald Haan, Stephen J. Szilvassy, Bert Dontje
Publikováno v:
Blood. 96:1374-1379
We have previously demonstrated that young adult DBA/2 (DBA) mice have more stem cells than C57BL/6 (B6) mice, as measured in a cobblestone area-forming cell (CAFC) assay using unfractionated marrow. To study the nature of this difference, we have no
Autor:
de Gerald Haan, G Van Zant
Publikováno v:
Blood. 93:3294-3301
To address the fundamental question of whether or not stem cell populations age, we performed quantitative measurements of the cycling status and frequency of hematopoietic stem cells in long-lived C57BL/6 (B6) and short-lived DBA/2 (DBA) mice at dif
Publikováno v:
Leukemia, 27, 7, pp. 1613-4
Leukemia, 27, 1613-4
Leukemia, 27(7), 1613-1614. Nature Publishing Group
Leukemia, 27, 1613-4
Leukemia, 27(7), 1613-1614. Nature Publishing Group
The canonical Wnt-β-catenin pathway is an evolutionarily conserved and tightly regulated pathway in development. Activation of this pathway occurs upon binding of a soluble Wnt protein to a membrane-associated receptor, and leads to the disruption a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ab8ee08c772ad0eb2436256a9fbc7d1
https://hdl.handle.net/2066/118753
https://hdl.handle.net/2066/118753
Publikováno v:
British Journal of Haematology, 90(4), 783-790. Wiley
In this study we evaluated the in vivo effects of interleukin-11 (IL-11) and stem cell factor (SCF), in combination with erythropoietin (EPO) on murine erythropoiesis. Mice were treated for 7d with IL-11, SCF and EPO, each at three dose levels, In to
Autor:
de Gerald Haan, G Van Zant
Publikováno v:
The FASEB Journal, 13(6), 707-713. FEDERATION AMER SOC EXP BIOL
University of Groningen
Scopus-Elsevier
University of Groningen
Scopus-Elsevier
Normal somatic cells undergo replicative senescence in vitro but the significance of this process in organismic aging remains controversial. We have shown previously that hemopoietic stem cells of common inbred strains of mice vary widely in cycling
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31ee46f72b9d93fa5232bc60e2a515ac
https://research.rug.nl/en/publications/d250db32-6146-4773-85b5-42092d221d18
https://research.rug.nl/en/publications/d250db32-6146-4773-85b5-42092d221d18
Publikováno v:
Blood, 86(8), 2986-2992. AMER SOC HEMATOLOGY
Europe PubMed Central
Scopus-Elsevier
Europe PubMed Central
Scopus-Elsevier
Because of the complexity of appropriate stem cell assays, little information on the in vivo regulation of murine stem cell biology or stemmatopoiesis is available. It is unknown whether and how in vivo the primitive hematopoietic stem cell compartme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cb115129dc96bda5dee35cc63c12f03
https://research.rug.nl/en/publications/ef8a4513-6b04-4b40-a012-0f672717fc6d
https://research.rug.nl/en/publications/ef8a4513-6b04-4b40-a012-0f672717fc6d
Publikováno v:
Blood, 84(12), 4157-4163. AMER SOC HEMATOLOGY
Scopus-Elsevier
Europe PubMed Central
Scopus-Elsevier
Europe PubMed Central
We investigated the in vivo effects of erythropoietin (EPO) on granulopoiesis and, conversely, the effect of granulocyte colony-stimulating factor (G-CSF) treatment on erythropoiesis. Recombinant human EPO at four different doses in combination with