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Progressive telomere shortening during lifespan is associated with increased genome instability, block to cell proliferation and aging. Apoptosis and senescence are the two main cellular outcomes upon irreversible cell damage. In this study, we show
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Akademický článek
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Autor:
Garcia-Donas J; HM Hospitales-Centro Integral Oncológico HM Clara Campal, Oña Street 10, 28050, Madrid, Spain. jgarciadonas@hmhospitales.com., Hurtado A; Hospital Universitario Fundación Alcorcón, Alcorcón, Spain., Garrigos L; Hospital Universitario del Mar, Barcelona, Spain., Santaballa A; Hospital Universitario La Fe, Valencia, Spain., Redondo A; Hospital Universitario La Paz, Madrid, Spain., Vidal L; Hospital Universitario Clinico de Barcelona, Barcelona, Spain., Lainez N; Hospital de Navarra, Pamplona, Spain., Guerra E; Hospital Universitario Ramon y Cajal, Madrid, Spain., Rodriguez V; Hospital Universitario Valle Ebron, Barcelona, Spain., Cueva J; Complexo Hospital Universitario de Santiago de Compostela, Santiago de Compostela, Spain., Bover I; Hospital Universitario Son Llatzer, Mallorca, Spain., Palacio I; Hospital Central de Asturias, Oviedo, Spain., Rubio MJ; Hospital Universitario Reina Sofía, Cordoba, Spain., Prieto M; HM Hospitales-Centro Integral Oncológico HM Clara Campal, Oña Street 10, 28050, Madrid, Spain., Lopez-Guerrero JA; Fundacion Instituto Valenciano de Oncología, Valencia, Spain., Rodriguez-Moreno JF; HM Hospitales-Centro Integral Oncológico HM Clara Campal, Oña Street 10, 28050, Madrid, Spain., Garcia-Casado Z; Fundacion Instituto Valenciano de Oncología, Valencia, Spain., Garcia-Martinez E; Hospital General Universitario Morales Meseguer, Murcia, Spain., Taus A; Hospital Universitario del Mar, Barcelona, Spain., de Castro IP; Institute of Rare Diseases Research, Instituto de Salud Carlos III, Madrid, Spain., Navarro P; HM Hospitales-Centro Integral Oncológico HM Clara Campal, Oña Street 10, 28050, Madrid, Spain., Grande E; Anderson Cancer Center, Madrid, Spain.
Publikováno v:
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico [Clin Transl Oncol] 2023 Jul; Vol. 25 (7), pp. 2090-2098. Date of Electronic Publication: 2023 Jan 28.
Autor:
Dos Reis TFM; School of Veterinary Medicine, Federal University of Uberlândia, Uberlândia, Brazil., Hoepers PG; School of Veterinary Medicine, Federal University of Uberlândia, Uberlândia, Brazil. patriciag.hoepers@gmail.com., Azevedo VAC; Graduate Program in Genetics at the Federal University of Minas Gerais, Belo Horizonte, Brazil., da Silva GR; School of Veterinary Medicine, Federal University of Uberlândia, Uberlândia, Brazil., Notário FO; School of Veterinary Medicine, Federal University of Uberlândia, Uberlândia, Brazil., Soares MC; School of Veterinary Medicine, Federal University of Uberlândia, Uberlândia, Brazil., Schlemper AE; School of Veterinary Medicine, Federal University of Uberlândia, Uberlândia, Brazil., Costa ÍM; School of Veterinary Medicine, Federal University of Uberlândia, Uberlândia, Brazil., Coelho-Rocha ND; Graduate Program in Genetics at the Federal University of Minas Gerais, Belo Horizonte, Brazil., da Costa MS; Graduate Program in Genetics and Biochemistry at the Federal University of Uberlândia, Uberlândia, Brazil., Sommerfeld S; School of Veterinary Medicine, Federal University of Uberlândia, Uberlândia, Brazil., Medeiros-Ronchi AA; School of Veterinary Medicine, Federal University of Uberlândia, Uberlândia, Brazil., Rossi DA; School of Veterinary Medicine, Federal University of Uberlândia, Uberlândia, Brazil., de Castro IP; School of Veterinary Medicine, Federal University of Uberlândia, Uberlândia, Brazil., Fonseca BB; School of Veterinary Medicine, Federal University of Uberlândia, Uberlândia, Brazil. biafonseca@ufu.br.; Graduate Program in Genetics and Biochemistry at the Federal University of Uberlândia, Uberlândia, Brazil. biafonseca@ufu.br.
Publikováno v:
Archives of microbiology [Arch Microbiol] 2022 Nov 19; Vol. 204 (12), pp. 715. Date of Electronic Publication: 2022 Nov 19.
Autor:
El Maï M; Institute for Research on Cancer and Aging of Nice (IRCAN), Université Côte d'Azur, Nice, France.; Instituto Gulbenkian de Ciência, Oeiras, Portugal., Marzullo M; Instituto Gulbenkian de Ciência, Oeiras, Portugal., de Castro IP; Instituto Gulbenkian de Ciência, Oeiras, Portugal., Ferreira MG; Institute for Research on Cancer and Aging of Nice (IRCAN), Université Côte d'Azur, Nice, France.; Instituto Gulbenkian de Ciência, Oeiras, Portugal.
Publikováno v:
ELife [Elife] 2020 May 19; Vol. 9. Date of Electronic Publication: 2020 May 19.
Autor:
Carneiro MC; Instituto Gulbenkian de Ciência, Oeiras, Portugal., de Castro IP; Instituto Gulbenkian de Ciência, Oeiras, Portugal., Ferreira MG; Instituto Gulbenkian de Ciência, Oeiras, Portugal mgferreira@igc.gulbenkian.pt.
Publikováno v:
Disease models & mechanisms [Dis Model Mech] 2016 Jul 01; Vol. 9 (7), pp. 737-48.
Autor:
Piazzolla D; Tumour Suppression Group, Spanish National Cancer Research Centre (CNIO), Madrid 28029, Spain., Palla AR; 1] Tumour Suppression Group, Spanish National Cancer Research Centre (CNIO), Madrid 28029, Spain [2]., Pantoja C; 1] Tumour Suppression Group, Spanish National Cancer Research Centre (CNIO), Madrid 28029, Spain [2]., Cañamero M; Histopathology Core Unit, CNIO, Madrid 28029, Spain., de Castro IP; Cell Division and Cancer Group, CNIO, Madrid 28029, Spain., Ortega S; Transgenic Mice Core Unit, CNIO, Madrid 28029, Spain., Gómez-López G; Bioinformatics Unit, CNIO, Madrid 28029, Spain., Dominguez O; Genomics Core Unit, CNIO, Madrid 28029, Spain., Megías D; Confocal Microscopy Core Unit, CNIO, Madrid 28029, Spain., Roncador G; Monoclonal Antibodies Core Unit, Spanish National Cancer Research Centre (CNIO), Madrid 28029, Spain., Luque-Garcia JL; Department of Analytical Chemistry, Faculty of Chemistry, Complutense University of Madrid, Madrid 28040, Spain., Fernandez-Tresguerres B; Department of Cardiovascular Development and Repair, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid 28029, Spain., Fernandez AF; Cancer Epigenetics Laboratory, Instituto Universitario de Oncología del Principado de Asturias (IUOPA), HUCA, Universidad de Oviedo, Oviedo 33006, Spain., Fraga MF; 1] Cancer Epigenetics Laboratory, Instituto Universitario de Oncología del Principado de Asturias (IUOPA), HUCA, Universidad de Oviedo, Oviedo 33006, Spain [2] Department of Immunology and Oncology, Centro Nacional de Biotecnología/CNB-CSIC, Madrid 28049, Spain., Rodriguez-Justo M; Department of Pathology, University College Hospital, London NW1 2BU, UK., Manzanares M; Department of Cardiovascular Development and Repair, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid 28029, Spain., Sánchez-Carbayo M; CIC bioGUNE, Bizkaia Technology Park, Derio 48160 and Ikerbasque, Basque Foundation for Science, Bilbao 48011, Spain., García-Pedrero JM; Department of Otolaryngology, Hospital Universitario Central de Asturias and Instituto Universitario de Oncología del Principado de Asturias (IUOPA), Universidad de Oviedo, Oviedo 33006, Spain., Rodrigo JP; Department of Otolaryngology, Hospital Universitario Central de Asturias and Instituto Universitario de Oncología del Principado de Asturias (IUOPA), Universidad de Oviedo, Oviedo 33006, Spain., Malumbres M; Cell Division and Cancer Group, CNIO, Madrid 28029, Spain., Serrano M; Tumour Suppression Group, Spanish National Cancer Research Centre (CNIO), Madrid 28029, Spain.
Publikováno v:
Nature communications [Nat Commun] 2014 Jun 30; Vol. 5, pp. 4226. Date of Electronic Publication: 2014 Jun 30.
Autor:
Tufi R; MRC Toxicology Unit, Lancaster Road, Leicester LE1 9HN, UK., Gandhi S; Department of Molecular Neuroscience, Institute of Neurology, Queen Square, London WC1N 3BG, UK., de Castro IP; MRC Toxicology Unit, Lancaster Road, Leicester LE1 9HN, UK., Lehmann S; MRC Toxicology Unit, Lancaster Road, Leicester LE1 9HN, UK., Angelova PR; Department of Molecular Neuroscience, Institute of Neurology, Queen Square, London WC1N 3BG, UK., Dinsdale D; MRC Toxicology Unit, Lancaster Road, Leicester LE1 9HN, UK., Deas E; Department of Molecular Neuroscience, Institute of Neurology, Queen Square, London WC1N 3BG, UK., Plun-Favreau H; Department of Molecular Neuroscience, Institute of Neurology, Queen Square, London WC1N 3BG, UK., Nicotera P; German Centre for Neurodegenerative Diseases (DZNE), Ludwig-Erhard-Allee 2, 53175 Bonn, Germany., Abramov AY; Department of Molecular Neuroscience, Institute of Neurology, Queen Square, London WC1N 3BG, UK., Willis AE; MRC Toxicology Unit, Lancaster Road, Leicester LE1 9HN, UK., Mallucci GR; MRC Toxicology Unit, Lancaster Road, Leicester LE1 9HN, UK., Loh SH; MRC Toxicology Unit, Lancaster Road, Leicester LE1 9HN, UK., Martins LM; MRC Toxicology Unit, Lancaster Road, Leicester LE1 9HN, UK.
Publikováno v:
Nature cell biology [Nat Cell Biol] 2014 Feb; Vol. 16 (2), pp. 157-66. Date of Electronic Publication: 2014 Jan 19.
Autor:
de Castro IP; Cell Death Regulation Laboratory, MRC Toxicology Unit, Lancaster Road, Leicester LE1 9HN, UK., Costa AC, Celardo I, Tufi R, Dinsdale D, Loh SH, Martins LM
Publikováno v:
Cell death & disease [Cell Death Dis] 2013 Oct 24; Vol. 4, pp. e873. Date of Electronic Publication: 2013 Oct 24.
Autor:
Osei-Sarfo K; Department of Pathology, New York University Langone Medical Center, New York, NY 10016, USA., de Castro IP, Pellicer A
Publikováno v:
Carcinogenesis [Carcinogenesis] 2012 Mar; Vol. 33 (3), pp. 708-13. Date of Electronic Publication: 2012 Jan 06.