Regulation and Function of Syk Tyrosine Kinase in Mast Cell Signaling and Beyond

Autor: de Castro, Rodrigo Orlandini

Publikováno v: Journal of Signal Transduction.

The protein tyrosine kinase Syk plays a critical role in FcεRI signaling in mast cells. Binding of Syk to phosphorylated immunoreceptor tyrosine-based activation motifs (p-ITAM) of the receptor subunits results in conformational changes and tyrosine

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The alpha-galactosyl derivatives of ganglioside GD(1b) are essential for the organization of lipid rafts in RBL-2H3 mast cells.

Autor: Silveira e Souza AM; Department of Cell and Molecular Biology and Pathogenic Bioagents, Faculdade de Medicina de Ribeirão Preto-Universidade de São Paulo, Ribeirão Preto, SP, Brazil., Mazucato VM, de Castro RO, Matioli F, Ciancaglini P, de Paiva Paulino T, Jamur MC, Oliver C

Publikováno v: Experimental cell research [Exp Cell Res] 2008 Aug 01; Vol. 314 (13), pp. 2515-28. Date of Electronic Publication: 2008 Jun 27.