Comprehensive analysis of neuronal guidance cue expression regulation during monocyte-to-macrophage differentiation reveals post-transcriptional regulation of semaphorin7A by the RNA-binding protein quaking.

Autor: Zhang H; Einthoven Laboratory for Vascular and Regenerative Medicine, Department of Internal Medicine, Leiden University Medical Centre, The Netherlands., Prins J; Einthoven Laboratory for Vascular and Regenerative Medicine, Department of Internal Medicine, Leiden University Medical Centre, The Netherlands., Vreeken D; Einthoven Laboratory for Vascular and Regenerative Medicine, Department of Internal Medicine, Leiden University Medical Centre, The Netherlands., Florijn BW; Einthoven Laboratory for Vascular and Regenerative Medicine, Department of Internal Medicine, Leiden University Medical Centre, The Netherlands., de Bruin RG; Einthoven Laboratory for Vascular and Regenerative Medicine, Department of Internal Medicine, Leiden University Medical Centre, The Netherlands., van Hengel OR; Einthoven Laboratory for Vascular and Regenerative Medicine, Department of Internal Medicine, Leiden University Medical Centre, The Netherlands., van Essen MF; Einthoven Laboratory for Vascular and Regenerative Medicine, Department of Internal Medicine, Leiden University Medical Centre, The Netherlands., Duijs JM; Einthoven Laboratory for Vascular and Regenerative Medicine, Department of Internal Medicine, Leiden University Medical Centre, The Netherlands., Van Esch H; Department of Human Genetics, University Hospitals Leuven, Belgium., van der Veer EP; Einthoven Laboratory for Vascular and Regenerative Medicine, Department of Internal Medicine, Leiden University Medical Centre, The Netherlands., van Zonneveld AJ; Einthoven Laboratory for Vascular and Regenerative Medicine, Department of Internal Medicine, Leiden University Medical Centre, The Netherlands., Gils JMV; Einthoven Laboratory for Vascular and Regenerative Medicine, Department of Internal Medicine, Leiden University Medical Centre, The Netherlands.

Publikováno v: Innate immunity [Innate Immun] 2021 Feb; Vol. 27 (2), pp. 118-132. Date of Electronic Publication: 2020 Nov 26.

Targeting the RNA-Binding Protein QKI in Myeloid Cells Ameliorates Macrophage-Induced Renal Interstitial Fibrosis.

Autor: de Bruin RG; Einthoven Laboratory for Experimental Vascular Medicine, Division of Nephrology, Department of Internal Medicine, Leiden University Medical Center, Albinusdreef 2, C7-36, PO Box 9600, 2300RC Leiden, The Netherlands.; Segal Cancer Center, Lady Davis Institute for Medical Research and Gerald Bronfman Department of Oncology and Departments of Biochemistry, Human Genetics and Medicine, McGill University, Montréal, QC H3T 1E2, Canada., Vogel G; Segal Cancer Center, Lady Davis Institute for Medical Research and Gerald Bronfman Department of Oncology and Departments of Biochemistry, Human Genetics and Medicine, McGill University, Montréal, QC H3T 1E2, Canada., Prins J; Einthoven Laboratory for Experimental Vascular Medicine, Division of Nephrology, Department of Internal Medicine, Leiden University Medical Center, Albinusdreef 2, C7-36, PO Box 9600, 2300RC Leiden, The Netherlands., Duijs JMJG; Einthoven Laboratory for Experimental Vascular Medicine, Division of Nephrology, Department of Internal Medicine, Leiden University Medical Center, Albinusdreef 2, C7-36, PO Box 9600, 2300RC Leiden, The Netherlands., Bijkerk R; Einthoven Laboratory for Experimental Vascular Medicine, Division of Nephrology, Department of Internal Medicine, Leiden University Medical Center, Albinusdreef 2, C7-36, PO Box 9600, 2300RC Leiden, The Netherlands., van der Zande HJP; Einthoven Laboratory for Experimental Vascular Medicine, Division of Nephrology, Department of Internal Medicine, Leiden University Medical Center, Albinusdreef 2, C7-36, PO Box 9600, 2300RC Leiden, The Netherlands., van Gils JM; Einthoven Laboratory for Experimental Vascular Medicine, Division of Nephrology, Department of Internal Medicine, Leiden University Medical Center, Albinusdreef 2, C7-36, PO Box 9600, 2300RC Leiden, The Netherlands., de Boer HC; Einthoven Laboratory for Experimental Vascular Medicine, Division of Nephrology, Department of Internal Medicine, Leiden University Medical Center, Albinusdreef 2, C7-36, PO Box 9600, 2300RC Leiden, The Netherlands., Rabelink TJ; Einthoven Laboratory for Experimental Vascular Medicine, Division of Nephrology, Department of Internal Medicine, Leiden University Medical Center, Albinusdreef 2, C7-36, PO Box 9600, 2300RC Leiden, The Netherlands., van Zonneveld AJ; Einthoven Laboratory for Experimental Vascular Medicine, Division of Nephrology, Department of Internal Medicine, Leiden University Medical Center, Albinusdreef 2, C7-36, PO Box 9600, 2300RC Leiden, The Netherlands., van der Veer EP; Einthoven Laboratory for Experimental Vascular Medicine, Division of Nephrology, Department of Internal Medicine, Leiden University Medical Center, Albinusdreef 2, C7-36, PO Box 9600, 2300RC Leiden, The Netherlands., Richard S; Segal Cancer Center, Lady Davis Institute for Medical Research and Gerald Bronfman Department of Oncology and Departments of Biochemistry, Human Genetics and Medicine, McGill University, Montréal, QC H3T 1E2, Canada.

Publikováno v: Epigenomes [Epigenomes] 2020 Feb 13; Vol. 4 (1). Date of Electronic Publication: 2020 Feb 13.

MicroRNA-132 controls water homeostasis through regulating MECP2-mediated vasopressin synthesis.

Autor: Bijkerk R; Department of Internal Medicine (Nephrology) and the Einthoven Laboratory for Vascular and Regenerative Medicine, Leiden University Medical Center , Leiden , The Netherlands.; Renal Division, Department of Medicine, Brigham & Women's Hospital and Harvard Medical School , Boston, Massachusetts., Trimpert C; Department of Physiology, Radboud University Medical Center , Nijmegen , The Netherlands., van Solingen C; Department of Internal Medicine (Nephrology) and the Einthoven Laboratory for Vascular and Regenerative Medicine, Leiden University Medical Center , Leiden , The Netherlands.; Marc and Ruti Bell Vascular Biology and Disease Program, Leon H. Charney Division of Cardiology, Department of Medicine, New York University Medical Center , New York, New York., de Bruin RG; Department of Internal Medicine (Nephrology) and the Einthoven Laboratory for Vascular and Regenerative Medicine, Leiden University Medical Center , Leiden , The Netherlands., Florijn BW; Department of Internal Medicine (Nephrology) and the Einthoven Laboratory for Vascular and Regenerative Medicine, Leiden University Medical Center , Leiden , The Netherlands., Kooijman S; Department of Internal Medicine (Endocrinology) and the Einthoven Laboratory for Vascular and Regenerative Medicine, Leiden University Medical Center , Leiden , The Netherlands., van den Berg R; Department of Internal Medicine (Endocrinology) and the Einthoven Laboratory for Vascular and Regenerative Medicine, Leiden University Medical Center , Leiden , The Netherlands., van der Veer EP; Department of Internal Medicine (Nephrology) and the Einthoven Laboratory for Vascular and Regenerative Medicine, Leiden University Medical Center , Leiden , The Netherlands., Bredewold EOW; Department of Internal Medicine (Nephrology) and the Einthoven Laboratory for Vascular and Regenerative Medicine, Leiden University Medical Center , Leiden , The Netherlands., Rensen PCN; Department of Internal Medicine (Endocrinology) and the Einthoven Laboratory for Vascular and Regenerative Medicine, Leiden University Medical Center , Leiden , The Netherlands., Rabelink TJ; Department of Internal Medicine (Nephrology) and the Einthoven Laboratory for Vascular and Regenerative Medicine, Leiden University Medical Center , Leiden , The Netherlands., Humphreys BD; Renal Division, Department of Medicine, Brigham & Women's Hospital and Harvard Medical School , Boston, Massachusetts.; Renal Division, Washington University School of Medicine , St. Louis, Missouri., Deen PMT; Department of Physiology, Radboud University Medical Center , Nijmegen , The Netherlands., van Zonneveld AJ; Department of Internal Medicine (Nephrology) and the Einthoven Laboratory for Vascular and Regenerative Medicine, Leiden University Medical Center , Leiden , The Netherlands.

Publikováno v: American journal of physiology. Renal physiology [Am J Physiol Renal Physiol] 2018 Oct 01; Vol. 315 (4), pp. F1129-F1138. Date of Electronic Publication: 2018 May 30.

Silencing of microRNA-132 reduces renal fibrosis by selectively inhibiting myofibroblast proliferation.

Autor: Bijkerk R; Department of Nephrology and the Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center (LUMC), Leiden, the Netherlands; Renal Division, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA. Electronic address: r.bijkerk@lumc.nl., de Bruin RG; Department of Nephrology and the Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center (LUMC), Leiden, the Netherlands., van Solingen C; Department of Nephrology and the Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center (LUMC), Leiden, the Netherlands., van Gils JM; Department of Nephrology and the Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center (LUMC), Leiden, the Netherlands., Duijs JM; Department of Nephrology and the Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center (LUMC), Leiden, the Netherlands., van der Veer EP; Department of Nephrology and the Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center (LUMC), Leiden, the Netherlands., Rabelink TJ; Department of Nephrology and the Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center (LUMC), Leiden, the Netherlands., Humphreys BD; Renal Division, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA; Renal Division, Washington University School of Medicine, St. Louis, Missouri, USA., van Zonneveld AJ; Department of Nephrology and the Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center (LUMC), Leiden, the Netherlands.

Publikováno v: Kidney international [Kidney Int] 2016 Jun; Vol. 89 (6), pp. 1268-80. Date of Electronic Publication: 2016 Apr 08.

Quaking promotes monocyte differentiation into pro-atherogenic macrophages by controlling pre-mRNA splicing and gene expression.

Autor: de Bruin RG; Einthoven Laboratory of Experimental Vascular Medicine, Leiden University Medical Center, Albinusdreef 2, 2300RC Leiden, The Netherlands.; Department of Internal Medicine (Nephrology), Leiden University Medical Center, Albinusdreef 2, C7-36, PO Box 9600, 2300RC, Leiden The Netherlands., Shiue L; Center for Molecular Biology of RNA, Department of Molecular, Cell and Developmental Biology, University of California, 1156 High Street, Santa Cruz, California 95064, USA., Prins J; Einthoven Laboratory of Experimental Vascular Medicine, Leiden University Medical Center, Albinusdreef 2, 2300RC Leiden, The Netherlands.; Department of Internal Medicine (Nephrology), Leiden University Medical Center, Albinusdreef 2, C7-36, PO Box 9600, 2300RC, Leiden The Netherlands., de Boer HC; Einthoven Laboratory of Experimental Vascular Medicine, Leiden University Medical Center, Albinusdreef 2, 2300RC Leiden, The Netherlands.; Department of Internal Medicine (Nephrology), Leiden University Medical Center, Albinusdreef 2, C7-36, PO Box 9600, 2300RC, Leiden The Netherlands., Singh A; Department of Pathology, CARIM, Academic University Hospital Maastricht, P. Debyelaan 25, 6229HX Maastricht, The Netherlands., Fagg WS; Center for Molecular Biology of RNA, Department of Molecular, Cell and Developmental Biology, University of California, 1156 High Street, Santa Cruz, California 95064, USA., van Gils JM; Einthoven Laboratory of Experimental Vascular Medicine, Leiden University Medical Center, Albinusdreef 2, 2300RC Leiden, The Netherlands.; Department of Internal Medicine (Nephrology), Leiden University Medical Center, Albinusdreef 2, C7-36, PO Box 9600, 2300RC, Leiden The Netherlands., Duijs JM; Einthoven Laboratory of Experimental Vascular Medicine, Leiden University Medical Center, Albinusdreef 2, 2300RC Leiden, The Netherlands.; Department of Internal Medicine (Nephrology), Leiden University Medical Center, Albinusdreef 2, C7-36, PO Box 9600, 2300RC, Leiden The Netherlands., Katzman S; Center for Molecular Biology of RNA, Department of Molecular, Cell and Developmental Biology, University of California, 1156 High Street, Santa Cruz, California 95064, USA., Kraaijeveld AO; Department of Cardiology, Leiden University Medical Center, Albinusdreef 2, 2300RC Leiden, The Netherlands., Böhringer S; Department of Medical Biostatistics, Leiden University Medical Center, Albinusdreef 2, 2300RC Leiden, The Netherlands., Leung WY; Department of Sequencing Analysis Support Core, Leiden University Medical Center, Albinusdreef 2, 2300RC Leiden, The Netherlands., Kielbasa SM; Department of Medical Biostatistics, Leiden University Medical Center, Albinusdreef 2, 2300RC Leiden, The Netherlands., Donahue JP; Center for Molecular Biology of RNA, Department of Molecular, Cell and Developmental Biology, University of California, 1156 High Street, Santa Cruz, California 95064, USA., van der Zande PH; Einthoven Laboratory of Experimental Vascular Medicine, Leiden University Medical Center, Albinusdreef 2, 2300RC Leiden, The Netherlands.; Department of Internal Medicine (Nephrology), Leiden University Medical Center, Albinusdreef 2, C7-36, PO Box 9600, 2300RC, Leiden The Netherlands., Sijbom R; Einthoven Laboratory of Experimental Vascular Medicine, Leiden University Medical Center, Albinusdreef 2, 2300RC Leiden, The Netherlands.; Department of Internal Medicine (Nephrology), Leiden University Medical Center, Albinusdreef 2, C7-36, PO Box 9600, 2300RC, Leiden The Netherlands., van Alem CM; Department of Internal Medicine (Nephrology), Leiden University Medical Center, Albinusdreef 2, C7-36, PO Box 9600, 2300RC, Leiden The Netherlands., Bot I; Division of Biopharmaceutics, Leiden/Amsterdam Center for Drug Research, Leiden University, Einsteinweg 55, 2333CC Leiden, The Netherlands., van Kooten C; Department of Internal Medicine (Nephrology), Leiden University Medical Center, Albinusdreef 2, C7-36, PO Box 9600, 2300RC, Leiden The Netherlands., Jukema JW; Department of Cardiology, Leiden University Medical Center, Albinusdreef 2, 2300RC Leiden, The Netherlands.; Durrer Center for Cardiogenetic Research, Meiburgdreef 9, 1105AZ Amsterdam, The Netherlands., Van Esch H; Department of Human Genetics, University Hospitals Leuven, Herestraat 43, 3000 Leuven, Belgium., Rabelink TJ; Einthoven Laboratory of Experimental Vascular Medicine, Leiden University Medical Center, Albinusdreef 2, 2300RC Leiden, The Netherlands.; Department of Internal Medicine (Nephrology), Leiden University Medical Center, Albinusdreef 2, C7-36, PO Box 9600, 2300RC, Leiden The Netherlands., Kazan H; Department of Computer Engineering, Antalya International University, Universit Cad. No.2, Antalya 07190, Turkey., Biessen EA; Department of Pathology, CARIM, Academic University Hospital Maastricht, P. Debyelaan 25, 6229HX Maastricht, The Netherlands.; Division of Biopharmaceutics, Leiden/Amsterdam Center for Drug Research, Leiden University, Einsteinweg 55, 2333CC Leiden, The Netherlands., Ares M Jr; Center for Molecular Biology of RNA, Department of Molecular, Cell and Developmental Biology, University of California, 1156 High Street, Santa Cruz, California 95064, USA., van Zonneveld AJ; Einthoven Laboratory of Experimental Vascular Medicine, Leiden University Medical Center, Albinusdreef 2, 2300RC Leiden, The Netherlands.; Department of Internal Medicine (Nephrology), Leiden University Medical Center, Albinusdreef 2, C7-36, PO Box 9600, 2300RC, Leiden The Netherlands., van der Veer EP; Einthoven Laboratory of Experimental Vascular Medicine, Leiden University Medical Center, Albinusdreef 2, 2300RC Leiden, The Netherlands.; Department of Internal Medicine (Nephrology), Leiden University Medical Center, Albinusdreef 2, C7-36, PO Box 9600, 2300RC, Leiden The Netherlands.

Publikováno v: Nature communications [Nat Commun] 2016 Mar 31; Vol. 7, pp. 10846. Date of Electronic Publication: 2016 Mar 31.