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Mechanisms of sensitivity and resistance to CDK4/CDK6 inhibitors in hormone receptor-positive breast cancer treatment.

Autor: Glaviano A; Department of Biological, Chemical and Pharmaceutical Sciences and Technologies, University of Palermo, Palermo 90123, Italy., Wander SA; Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA., Baird RD; Cancer Research UK Cambridge Centre, Hills Road, Cambridge CB2 0QQ, UK., Yap KC; Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117600, Singapore; NUS Center for Cancer Research, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119077, Singapore., Lam HY; Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117600, Singapore; NUS Center for Cancer Research, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119077, Singapore., Toi M; School of Medicine, Kyoto University, Kyoto, Japan., Carbone D; Department of Biological, Chemical and Pharmaceutical Sciences and Technologies, University of Palermo, Palermo 90123, Italy., Geoerger B; Gustave Roussy Cancer Center, Department of Pediatric and Adolescent Oncology, Inserm U1015, Université Paris-Saclay, Villejuif, France., Serra V; Experimental Therapeutics Group, Vall d'Hebron Institute of Oncology, Barcelona, Spain., Jones RH; Cardiff University and Velindre Cancer Centre, Museum Avenue, Cardiff CF10 3AX, UK., Ngeow J; Lee Kong Chian School of Medicine (LKCMedicine), Nanyang Technological University, Experimental Medicine Building, 636921, Singapore; Cancer Genetics Service (CGS), National Cancer Centre Singapore, 168583, Singapore., Toska E; Department of Biochemistry and Molecular Biology, Johns Hopkins School of Public Health, Baltimore, MD, USA., Stebbing J; School of Life Sciences, Anglia Ruskin University, Cambridge, UK; Division of Cancer, Imperial College London, Hammersmith Campus, London, UK., Crasta K; NUS Center for Cancer Research, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119077, Singapore; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, 117593, Singapore; Healthy Longetivity Translational Program, Yong Loo Lin School of Medicine, National University of Singapore, 117456, Singapore., Finn RS; Department of Oncology, Geffen School of Medicine, University of California, Los Angeles, CA, USA., Diana P; Department of Biological, Chemical and Pharmaceutical Sciences and Technologies, University of Palermo, Palermo 90123, Italy., Vuina K; MRC Laboratory for Molecular Cell Biology, University College London, London WC1E 6BT, UK., de Bruin RAM; MRC Laboratory for Molecular Cell Biology, University College London, London WC1E 6BT, UK., Surana U; Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117600, Singapore; SiNOPSEE Therapeutics Pte Ltd, A⁎STARTCentral, 139955, Singapore., Bardia A; Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA., Kumar AP; Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117600, Singapore; NUS Center for Cancer Research, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119077, Singapore. Electronic address: apkumar@nus.edu.sg.

Publikováno v: Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy [Drug Resist Updat] 2024 Sep; Vol. 76, pp. 101103. Date of Electronic Publication: 2024 Jun 25.

Active growth signaling promotes senescence and cancer cell sensitivity to CDK7 inhibition.

Autor: Wilson GA; Laboratory for Molecular Cell Biology, University College London, London, UK., Vuina K; Laboratory for Molecular Cell Biology, University College London, London, UK., Sava G; Division of Cancer, Department of Surgery & Cancer, Imperial College London, London, UK., Huard C; Institute for Research in Immunology and Cancer, Université de Montréal, Montréal, QC, Canada., Meneguello L; Laboratory for Molecular Cell Biology, University College London, London, UK; UCL Cancer Institute, University College London, London, UK., Coulombe-Huntington J; Institute for Research in Immunology and Cancer, Université de Montréal, Montréal, QC, Canada; Department of Bioengineering, McGill University, Montréal, QC, Canada., Bertomeu T; Institute for Research in Immunology and Cancer, Université de Montréal, Montréal, QC, Canada., Maizels RJ; Laboratory for Molecular Cell Biology, University College London, London, UK., Lauring J; Janssen Research and Development, the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD, USA., Kriston-Vizi J; Laboratory for Molecular Cell Biology, University College London, London, UK., Tyers M; Institute for Research in Immunology and Cancer, Université de Montréal, Montréal, QC, Canada; Hospital for Sick Children, University of Toronto, Toronto, ON, Canada., Ali S; Division of Cancer, Department of Surgery & Cancer, Imperial College London, London, UK., Bertoli C; Laboratory for Molecular Cell Biology, University College London, London, UK. Electronic address: c.bertoli@ucl.ac.uk., de Bruin RAM; Laboratory for Molecular Cell Biology, University College London, London, UK; UCL Cancer Institute, University College London, London, UK. Electronic address: r.debruin@ucl.ac.uk.

Publikováno v: Molecular cell [Mol Cell] 2023 Nov 16; Vol. 83 (22), pp. 4078-4092.e6. Date of Electronic Publication: 2023 Nov 16.

A ferrocene-containing nucleoside analogue targets DNA replication in pancreatic cancer cells.

Autor: Rana M; School of Biosciences, The University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK.; School of Chemistry, The University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK., Perotti A; School of Biosciences, The University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK., Bisset LM; School of Biosciences, The University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK., Smith JD; School of Biosciences, The University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK., Lamden E; School of Biosciences, The University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK., Khan Z; School of Biosciences, The University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK., Ismail MK; Department of pharmacy, college of pharmacy, Knowledge University, 44001 Erbil, Kurdistan Region, Iraq., Ellis K; Institute of Cancer and Genomic Sciences, and The University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK., Armstrong KA; School of Biosciences, The University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK., Hodder SL; School of Biosciences, The University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK., Bertoli C; MRC Laboratory or Molecular Cell Biology, University College London, London, WC1E 6BT, UK., Meneguello L; MRC Laboratory or Molecular Cell Biology, University College London, London, WC1E 6BT, UK., de Bruin RAM; MRC Laboratory or Molecular Cell Biology, University College London, London, WC1E 6BT, UK., Morris JR; Institute of Cancer and Genomic Sciences, and The University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK., Romero-Canelon I; School of Pharmacy, The University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK., Tucker JHR; School of Chemistry, The University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK., Hodges NJ; School of Biosciences, The University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK.

Publikováno v: Metallomics : integrated biometal science [Metallomics] 2022 Jul 25; Vol. 14 (7).

Cell cycle control in cancer.

Autor: Matthews HK; MRC Laboratory for Molecular Cell Biology, University College London, London, UK.; Department of Biomedical Science, University of Sheffield, Sheffield, UK., Bertoli C; MRC Laboratory for Molecular Cell Biology, University College London, London, UK., de Bruin RAM; MRC Laboratory for Molecular Cell Biology, University College London, London, UK. r.debruin@ucl.ac.uk.; UCL Cancer Institute, University College London, London, UK. r.debruin@ucl.ac.uk.

Publikováno v: Nature reviews. Molecular cell biology [Nat Rev Mol Cell Biol] 2022 Jan; Vol. 23 (1), pp. 74-88. Date of Electronic Publication: 2021 Sep 10.