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Akademický článek

Hybrid Molecular and Functional Micro-CT Imaging Reveals Increased Myocardial Apoptosis Preceding Cardiac Failure in Progeroid Ercc1 Mice.

Autor: van Thiel BS; Department of Molecular Genetics, Erasmus MC Cancer Institute, Erasmus University Medical Center, Rotterdam, The Netherlands.; Department of Vascular Surgery, Erasmus MC Cardiovascular Institute, Erasmus University Medical Center, Room 702A, Wytemaweg 80, 3015 CN, Rotterdam, The Netherlands.; Division of Vascular Medicine and Pharmacology, Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands., de Boer M; Division of Experimental Cardiology, Department of Cardiology, Erasmus MC Cardiovascular Institute, Erasmus University Medical Center, Rotterdam, The Netherlands., Ridwan Y; Department of Molecular Genetics, Erasmus MC Cancer Institute, Erasmus University Medical Center, Rotterdam, The Netherlands.; Department of Radiotherapy, Erasmus University Medical Center, Room 702A, Wytemaweg 80, 3015 CN, Rotterdam, The Netherlands., de Kleijnen MGJ; Division of Experimental Cardiology, Department of Cardiology, Erasmus MC Cardiovascular Institute, Erasmus University Medical Center, Rotterdam, The Netherlands., van Vliet N; Department of Molecular Genetics, Erasmus MC Cancer Institute, Erasmus University Medical Center, Rotterdam, The Netherlands., van der Linden J; Department of Molecular Genetics, Erasmus MC Cancer Institute, Erasmus University Medical Center, Rotterdam, The Netherlands.; Division of Vascular Medicine and Pharmacology, Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands.; Division of Experimental Cardiology, Department of Cardiology, Erasmus MC Cardiovascular Institute, Erasmus University Medical Center, Rotterdam, The Netherlands., de Beer I; Department of Molecular Genetics, Erasmus MC Cancer Institute, Erasmus University Medical Center, Rotterdam, The Netherlands., van Heijningen PM; Department of Molecular Genetics, Erasmus MC Cancer Institute, Erasmus University Medical Center, Rotterdam, The Netherlands., Vermeij WP; Department of Molecular Genetics, Erasmus MC Cancer Institute, Erasmus University Medical Center, Rotterdam, The Netherlands.; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.; Oncode Institute, Utrecht, The Netherlands., Hoeijmakers JHJ; Department of Molecular Genetics, Erasmus MC Cancer Institute, Erasmus University Medical Center, Rotterdam, The Netherlands.; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.; Oncode Institute, Utrecht, The Netherlands.; Institute for Genome Stability in Aging and Disease, Cologne Excellence Cluster for Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany., Danser AHJ; Division of Vascular Medicine and Pharmacology, Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands., Kanaar R; Department of Molecular Genetics, Erasmus MC Cancer Institute, Erasmus University Medical Center, Rotterdam, The Netherlands.; Oncode Institute, Utrecht, The Netherlands., Duncker DJ; Division of Experimental Cardiology, Department of Cardiology, Erasmus MC Cardiovascular Institute, Erasmus University Medical Center, Rotterdam, The Netherlands., van der Pluijm I; Department of Molecular Genetics, Erasmus MC Cancer Institute, Erasmus University Medical Center, Rotterdam, The Netherlands. i.vanderpluijm@erasmusmc.nl.; Department of Vascular Surgery, Erasmus MC Cardiovascular Institute, Erasmus University Medical Center, Room 702A, Wytemaweg 80, 3015 CN, Rotterdam, The Netherlands. i.vanderpluijm@erasmusmc.nl., Essers J; Department of Molecular Genetics, Erasmus MC Cancer Institute, Erasmus University Medical Center, Rotterdam, The Netherlands. j.essers@erasmusmc.nl.; Department of Vascular Surgery, Erasmus MC Cardiovascular Institute, Erasmus University Medical Center, Room 702A, Wytemaweg 80, 3015 CN, Rotterdam, The Netherlands. j.essers@erasmusmc.nl.; Department of Radiotherapy, Erasmus University Medical Center, Room 702A, Wytemaweg 80, 3015 CN, Rotterdam, The Netherlands. j.essers@erasmusmc.nl.

Publikováno v: Molecular imaging and biology [Mol Imaging Biol] 2024 Aug; Vol. 26 (4), pp. 628-637. Date of Electronic Publication: 2024 Mar 18.

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Akademický článek

Ercc1 DNA repair deficiency results in vascular aging characterized by VSMC phenotype switching, ECM remodeling, and an increased stress response.

Autor: van der Linden J; Division of Vascular Medicine and Pharmacology, Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands.; Department of Molecular Genetics, Cancer Genomics Center, Erasmus University Medical Center, Rotterdam, The Netherlands., Stefens SJM; Department of Molecular Genetics, Cancer Genomics Center, Erasmus University Medical Center, Rotterdam, The Netherlands., Heredia-Genestar JM; Department of Molecular Genetics, Cancer Genomics Center, Erasmus University Medical Center, Rotterdam, The Netherlands., Ridwan Y; Department of Molecular Genetics, Cancer Genomics Center, Erasmus University Medical Center, Rotterdam, The Netherlands.; AMIE Core facility, Erasmus University Medical Center, Rotterdam, The Netherlands., Brandt RMC; Department of Molecular Genetics, Cancer Genomics Center, Erasmus University Medical Center, Rotterdam, The Netherlands., van Vliet N; Department of Molecular Genetics, Cancer Genomics Center, Erasmus University Medical Center, Rotterdam, The Netherlands., de Beer I; Department of Molecular Genetics, Cancer Genomics Center, Erasmus University Medical Center, Rotterdam, The Netherlands., van Thiel BS; Department of Molecular Genetics, Cancer Genomics Center, Erasmus University Medical Center, Rotterdam, The Netherlands., Steen H; Cortalix BV, Groningen, The Netherlands., Cheng C; Division of Experimental Cardiology, Department of Cardiology, MC Utrecht, Utrecht, The Netherlands.; Division of Internal Medicine and Dermatology, Department of Nephrology and Hypertension, MC Utrecht, Utrecht, The Netherlands., Roks AJM; Division of Vascular Medicine and Pharmacology, Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands., Danser AHJ; Division of Vascular Medicine and Pharmacology, Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands., Essers J; Department of Molecular Genetics, Cancer Genomics Center, Erasmus University Medical Center, Rotterdam, The Netherlands.; Department of Vascular Surgery, Cardiovascular Institute, Erasmus University Medical Center, Rotterdam, The Netherlands.; Department of Radiotherapy, Erasmus University Medical Center, Rotterdam, The Netherlands., van der Pluijm I; Department of Molecular Genetics, Cancer Genomics Center, Erasmus University Medical Center, Rotterdam, The Netherlands.; Department of Vascular Surgery, Cardiovascular Institute, Erasmus University Medical Center, Rotterdam, The Netherlands.

Publikováno v: Aging cell [Aging Cell] 2024 May; Vol. 23 (5), pp. e14126. Date of Electronic Publication: 2024 Mar 07.

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