Altered network and rescue of human neurons derived from individuals with early-onset genetic epilepsy.

Autor: Negraes PD; Department of Pediatrics, University of California San Diego, La Jolla, CA, USA., Trujillo CA; Department of Pediatrics, University of California San Diego, La Jolla, CA, USA. clebertrujillo@gmail.com., Yu NK; Department of Chemical Physiology, The Scripps Research Institute, La Jolla, CA, USA., Wu W; Department of Pediatrics, University of California San Diego, La Jolla, CA, USA., Yao H; Department of Pediatrics, University of California San Diego, La Jolla, CA, USA., Liang N; Department of Pediatrics, University of California San Diego, La Jolla, CA, USA., Lautz JD; Center for Integrative Brain Research, Seattle Children's Research Institute, Seattle, WA, USA.; Graduate Program in Neuroscience, University of Washington, Seattle, WA, USA., Kwok E; Department of Pediatrics, University of California San Diego, La Jolla, CA, USA., McClatchy D; Department of Chemical Physiology, The Scripps Research Institute, La Jolla, CA, USA., Diedrich J; Department of Chemical Physiology, The Scripps Research Institute, La Jolla, CA, USA., de Bartolome SM; Department of Chemical Physiology, The Scripps Research Institute, La Jolla, CA, USA., Truong J; Department of Pediatrics, University of California San Diego, La Jolla, CA, USA., Szeto R; Department of Pediatrics, University of California San Diego, La Jolla, CA, USA., Tran T; Department of Pediatrics, University of California San Diego, La Jolla, CA, USA., Herai RH; Experimental Multiuser Laboratory, Graduate Program in Health Sciences, School of Medicine, Pontifícia Universidade Católica do Paraná, Curitiba, Paraná, Brazil., Smith SEP; Center for Integrative Brain Research, Seattle Children's Research Institute, Seattle, WA, USA.; Graduate Program in Neuroscience, University of Washington, Seattle, WA, USA., Haddad GG; Department of Pediatrics, University of California San Diego, La Jolla, CA, USA.; Department of Neurosciences, University of California San Diego, La Jolla, CA, USA., Yates JR 3rd; Department of Chemical Physiology, The Scripps Research Institute, La Jolla, CA, USA., Muotri AR; Department of Pediatrics, University of California San Diego, La Jolla, CA, USA. muotri@ucsd.edu.; Kavli Institute for Brain and Mind, University of California San Diego, La Jolla, CA, USA. muotri@ucsd.edu.; Center for Academic Research and Training in Anthropogeny (CARTA), La Jolla, CA, USA. muotri@ucsd.edu.

Publikováno v: Molecular psychiatry [Mol Psychiatry] 2021 Nov; Vol. 26 (11), pp. 7047-7068. Date of Electronic Publication: 2021 Apr 22.