Zobrazeno 1 - 10
of 9 640
pro vyhledávání: '"ddr"'
Publikováno v:
Animal Cells and Systems, Vol 28, Iss 1, Pp 401-416 (2024)
Lamin A/C, a core component of the nuclear lamina, forms a mesh-like structure beneath the inner nuclear membrane. While its structural role is well-studied, its involvement in DNA metabolism remains unclear. We conducted sequential protein fractiona
Externí odkaz:
https://doaj.org/article/252959cfcbaf45b6943abeaefa027f3e
Autor:
Clare E. Murray, Anand V. R. Kornepati, Carlos Ontiveros, Yiji Liao, Bárbara de la Peña Avalos, Cody M. Rogers, Zexuan Liu, Yilun Deng, Haiyan Bai, Suresh Kari, Alvaro S. Padron, Jacob T. Boyd, Ryan Reyes, Curtis A. Clark, Robert S. Svatek, Rong Li, Yanfen Hu, Meiling Wang, José R. Conejo-Garcia, Lauren A. Byers, Kavya Ramkumar, Anil K. Sood, Jung-Min Lee, Christin E. Burd, Ratna K. Vadlamudi, Harshita B. Gupta, Weixing Zhao, Eloïse Dray, Patrick Sung, Tyler J. Curiel
Publikováno v:
Molecular Cancer, Vol 23, Iss 1, Pp 1-24 (2024)
Abstract Background Aside from the canonical role of PDL1 as a tumour surface-expressed immune checkpoint molecule, tumour-intrinsic PDL1 signals regulate non-canonical immunopathological pathways mediating treatment resistance whose significance, me
Externí odkaz:
https://doaj.org/article/324b033e9fa34bbcab45721b8054a03a
Publikováno v:
Cancer Cell International, Vol 24, Iss 1, Pp 1-15 (2024)
Abstract Bladder cancer stands as one of the most prevalent cancers worldwide. While our previous research confirmed the significant role of stearoyl-CoA desaturase (SCD) in bladder cancer, the underlying reasons for its abnormal overexpression remai
Externí odkaz:
https://doaj.org/article/9d23c1b0ae594d0591a3189e6e576037
Autor:
Yuhui Han, Wenjiong Sheng, Xiuxin Liu, Haide Liu, Xinyu Jia, Honghui Li, Changyuan Wang, Bin Wang, Tao Hu, Yanchao Ma
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract As one of the most common malignancies, colorectal cancer (CRC) usually starts with a benign lesion and accumulates DNA damage as it progresses to full-fledged cancer. Glycyrrhizin (GL) has been found to alleviate tumor growth and inflammati
Externí odkaz:
https://doaj.org/article/0cf42e116e3c44ee8e9fcb2a2c823d08
Publikováno v:
Cancer Management and Research, Vol Volume 16, Pp 1267-1283 (2024)
Bicky Thapa,1,* Navonil De Sarkar,2– 4,* Subhajit Giri,2,3 Komal Sharma,2– 4 Mingee Kim,5 Deepak Kilari1 1Division of Hematology and Oncology, Medical College of Wisconsin, Milwaukee, WI, USA; 2Medical College of Wisconsin Cancer Center,
Externí odkaz:
https://doaj.org/article/7099d4bb6250439690b805dadd42278b
Autor:
Janet L. Oblinger, Jack Wang, Georgia D. Wetherell, Garima Agarwal, Tyler A. Wilson, Nicole R. Benson, Joelle M. Fenger, James R. Fuchs, A. Douglas Kinghorn, Long-Sheng Chang
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-17 (2024)
Abstract Inhibition of translation initiation using eIF4A inhibitors like (−)-didesmethylrocaglamide [(−)-DDR] and (−)-rocaglamide [(−)-Roc] is a potential cancer treatment strategy as they simultaneously diminish multiple oncogenic drivers.
Externí odkaz:
https://doaj.org/article/9f51765470304068adff9d89398af258
Publikováno v:
Military Medical Research, Vol 11, Iss 1, Pp 1-36 (2024)
Abstract Small nucleolar RNAs (snoRNAs) were previously regarded as a class of functionally conserved housekeeping genes, primarily involved in the regulation of ribosome biogenesis by ribosomal RNA (rRNA) modification. However, some of them are invo
Externí odkaz:
https://doaj.org/article/c322321cb98548d28b7a45eb169a40f2
Autor:
Christian Wicke
Publikováno v:
Sub\urban, Vol 12, Iss 2/3 (2024)
Der komplexe Band Stadtwende. Bürgerengagement und Altstadterneuerung in der DDR und Ostdeutschland eröffnet neue Perspektiven bezüglich der Erforschung der deutschen Vereinigung von 1990. Herausgegeben von Jana Breßler, Harald Engler, Constanze
Externí odkaz:
https://doaj.org/article/a9ef21e878ad42cc931cebfb9f3934f8
Publikováno v:
Current Problems in Cancer: Case Reports, Vol 16, Iss , Pp 100321- (2024)
Breast cancer (BC) is a complex and heterogeneous disease including different biological subtypes. This results in molecular and phenotypic heterogeneity within the BC. Stratification of tumors contributed to achieving better outcome in terms of resp
Externí odkaz:
https://doaj.org/article/a9fea07d6ef8406188bfbc33eaab027b
Publikováno v:
Nucleus, Vol 15, Iss 1 (2024)
DNA double-strand break (DSB) is the most dangerous type of DNA damage, which may lead to cell death or oncogenic mutations. Homologous recombination (HR) and nonhomologous end-joining (NHEJ) are two typical DSB repair mechanisms. Recently, many stud
Externí odkaz:
https://doaj.org/article/7751d5556522435ca788274cdf66af7c