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of 2 653
pro vyhledávání: '"ddc:616.07"'
Autor:
Kristof Egervari, Yves Chalandon, Stavroula Masouridi, Anne-Claire Mamez, Maria Vargas, Karine Hadaya, Maria Anastasiou
Publikováno v:
BMJ case reports, Vol. 14, No 8 (2021) P. e238236
Central nervous system lymphoproliferative disorder (CNS-PTLD) after organ transplant is a unique clinicopathological entity and is associated with poor survival rates. When the CNS is involved, intravenous rituximab might not be the treatment of cho
Autor:
Alejandro Brigante, Barbara Russo, Denis Mongin, Kim Lauper, Danièle Allali, Delphine S. Courvoisier, Michele Iudici
Publikováno v:
Arthritis care & research (2022)
Objectives: To assess the proportion, the reasons, and the factors associated with discontinuation or nonpublication of randomized controlled trials (RCTs) on connective tissue diseases (CTDs).Methods: We searched all interventional RCTs on CTDs regi
Autor:
Paola Antinori, Eniko Veronika Kovari, Johannes Alexander Lobrinus, Pierre R. Burkhard, Affif Zaccaria, Virginie Licker
Publikováno v:
Cellular and molecular neurobiology (2021)
Dopaminergic neurons (DA) of the substantia nigra pars compacta (SNpc) selectively and progressively degenerate in Parkinson’s disease (PD). Until now, molecular analyses of DA in PD have been limited to genomic or transcriptomic approaches, wherea
Autor:
Frédéric Triponez, Hiba Mechahougui, Claudio De Vito, Nicolas Mach, William C. Faquin, Amanda H. Seipel
Publikováno v:
Head and Neck Pathology (2021)
Extra-osseous Ewing sarcoma (ES) is a rare and aggressive malignant tumor found in a variety of organs. Primary ES of the thyroid is exceedingly rare and few cases have been documented to date. We describe the case of a 54-year old woman with a histo
Immune response of polarized cystic fibrosis airway epithelial cells infected with Influenza A virus
Publikováno v:
King's College London
Journal of Cystic Fibrosis (2020)
Journal of Cystic Fibrosis (2020)
Background Cystic fibrosis (CF), a genetic disease caused by mutations of the cystic fibrosis transmembrane conductance regulator (CFTR) gene, is characterized by dysfunction of the immune response in the airway epithelium that leads to prolonged inf
Autor:
Karl-Heinz Krause, Marco Alessandrini, Silvia Acosta-Gutierrez, Carolina Estarellas, Sten Ilmjärv, Francesco Luigi Gervasio, Fabien Abdul, Marina Casimir, Ioannis Galdadas
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Scientific reports, Vol. 11, No 1 (2021) P. 13705
Scientific Reports
Scientific reports, Vol. 11, No 1 (2021) P. 13705
Scientific Reports
The D614G mutation in the Spike protein of the SARS-CoV-2 has effectively replaced the early pandemic-causing variant. Using pseudotyped lentivectors, we confirmed that the aspartate replacement by glycine in position 614 is markedly more infectious.
A mutual information-based in vivo monitoring of adaptive response to targeted therapies in melanoma
Publikováno v:
Neoplasia (New York, N.Y.)
Neoplasia, Vol. 23, No 8 (2021) pp. 775-782
Neoplasia: An International Journal for Oncology Research, Vol 23, Iss 8, Pp 775-782 (2021)
Neoplasia, Vol. 23, No 8 (2021) pp. 775-782
Neoplasia: An International Journal for Oncology Research, Vol 23, Iss 8, Pp 775-782 (2021)
The mechanisms of adaptive resistance to genetic-based targeted therapies of solid malignancies have been the subject of intense research. These studies hold great promise for finding co-targetable hub/pathways which in turn would control the downstr
Autor:
Zhenzhen Zhang, Yves Horsmans, Francesco Negro, Nasser Semmo, Fiona Marra, Carlos Roncero, Nuno Marques, Michael Gschwantler, Włodzimierz Mazur, Rawi Hazzan, Mark Bondin, Georges Philippe Pageaux, Robert Flisiak, Konstantinos Mimidis, Tarik Asselah, Harald Hofer, Suzanne Bourgeois, John Marcinak, Pietro Lampertico, Alessio Aghemo, Ella Veitsman, Ioannis Goulis
Publikováno v:
Aghemo, Alessio; Horsmans, Yves; Bourgeois, Stefan; Bondin, Mark; Gschwantler, Michael; Hofer, Harald; Semmo, Nasser; Negro, Francesco; Zhang, Zhenzhen; Marcinak, John; Veitsman, Ella; Hazzan, Rawi; Mimidis, Konstantinos; Goulis, Ioannis; Marques, Nuno; Flisiak, Robert; Mazur, Wlodzimierz; Roncero, Carlos; Marra, Fiona; Pageaux, Georges Philippe; ... (2021). Real-World Outcomes in Historically Underserved Patients with Chronic Hepatitis C Infection Treated with Glecaprevir/Pibrentasvir. Infectious diseases and therapy, 10(4), pp. 2203-2222. Springer 10.1007/s40121-021-00455-1
Infectious diseases and therapy, Vol. 10, no.4, p. 2203-2222 (2021)
Infectious Diseases and Therapy
Infectious Diseases and Therapy (2021)
Infectious diseases and therapy, Vol. 10, no.4, p. 2203-2222 (2021)
Infectious Diseases and Therapy
Infectious Diseases and Therapy (2021)
Introduction Glecaprevir/pibrentasvir is approved for treating chronic hepatitis C virus (HCV) genotypes (GT) 1–6. We evaluated real-world effectiveness, safety, and patient-reported outcomes of glecaprevir/pibrentasvir in underserved patient popul
Autor:
Vanzan, Ludovica, Soldati, Hadrien, Ythier, Victor, Anand, Santosh, Braun, Simon M. G., Francis, Nicole, Murr, Rabih
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Nature Communications
Nature Communications, Vol. 12, No 1 (2021) P. 3337
Nature Communications
Nature Communications, Vol. 12, No 1 (2021) P. 3337
Binding of mammalian transcription factors (TFs) to regulatory regions is hindered by chromatin compaction and DNA methylation of their binding sites. Nevertheless, pioneer transcription factors (PFs), a distinct class of TFs, have the ability to acc
Autor:
Idris Guessous, Laurent Kaiser, Nicolas Vuilleumier, Qifang Bi, Andrew S. Azman, Isabella Eckerle, Stephen A. Lauer, Derek A. T. Cummings, Justin Lessler, Silvia Stringhini, Dusan Petrovic, Antoine Flahault
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-8 (2021)
Nature Communications
Nature Communications, Vol. 12, No 1 (2021) P. 3643
Nature Communications
Nature Communications, Vol. 12, No 1 (2021) P. 3643
Understanding the risk of infection from household- and community-exposures and the transmissibility of asymptomatic infections is critical to SARS-CoV-2 control. Limited previous evidence is based primarily on virologic testing, which disproportiona