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of 63
pro vyhledávání: '"ddc:572.8"'
Translational Control by RNA-RNA Interaction: Improved Computation of RNA-RNA Binding Thermodynamics
Autor:
Mückstein, Ulrike, Tafer, Hakim, Bernhart, Stephan H., Hernandez-Rosales, Maribel, Vogel, Jörg, Stadler, Peter F., Hofacker, Ivo L.
The thermodynamics of RNA-RNA interaction consists of two components: the energy necessary to make a potential binding region accessible, i.e., unpaired, and the energy gained from the base pairing of the two interaction partners. We show here that b
Externí odkaz:
https://ul.qucosa.de/id/qucosa%3A32007
https://ul.qucosa.de/api/qucosa%3A32007/attachment/ATT-0/
https://ul.qucosa.de/api/qucosa%3A32007/attachment/ATT-0/
Autor:
Lehner, Wolfgang, Habich, Dirk, Richly, Sebastian, Assmann, Uwe, Grasselt, Mike, Maier, Albert, Pilarsky, Christian
In the context of genome research, the method of gene expression analysis has been used for several years. Related microarray experiments are conducted all over the world, and consequently, a vast amount of microarray data sets are produced. Having a
Externí odkaz:
https://tud.qucosa.de/id/qucosa%3A78849
https://tud.qucosa.de/api/qucosa%3A78849/attachment/ATT-0/
https://tud.qucosa.de/api/qucosa%3A78849/attachment/ATT-0/
Autor:
Prohaska, Sonja J., Stadler, Peter F.
High-throughput experiments have produced convicing evidence for an extensive contribution of diverse classes of RNAs in the expression of genetic information. Instead of a simple arrangement of mostly protein-coding genes, the human tran- scriptome
Externí odkaz:
https://ul.qucosa.de/id/qucosa%3A32008
https://ul.qucosa.de/api/qucosa%3A32008/attachment/ATT-0/
https://ul.qucosa.de/api/qucosa%3A32008/attachment/ATT-0/
The analysis of small circular sequences requires specialized tools. While the differences between linear and circular sequences can be neglected in the case of long molecules such as bacterial genomes since in practice all analysis is performed in s
Externí odkaz:
https://ul.qucosa.de/id/qucosa%3A32019
https://ul.qucosa.de/api/qucosa%3A32019/attachment/ATT-0/
https://ul.qucosa.de/api/qucosa%3A32019/attachment/ATT-0/
Unlike tRNAs and microRNAs, both classes of snoRNAs, which direct two distinct types of chemical modifications of uracil residues, have proved to be surprisingly difficult to find in genomic sequences. Most computational approaches so far have explic
Externí odkaz:
https://ul.qucosa.de/id/qucosa%3A32109
https://ul.qucosa.de/api/qucosa%3A32109/attachment/ATT-0/
https://ul.qucosa.de/api/qucosa%3A32109/attachment/ATT-0/
While studies of the evolutionary histories of protein families are commonplace, little is known on noncoding RNAs beyond microRNAs and some snoRNAs. Here we investigate in detail the evolutionary history of the nine spliceosomal snRNA families (U1,
Externí odkaz:
https://ul.qucosa.de/id/qucosa%3A32100
https://ul.qucosa.de/api/qucosa%3A32100/attachment/ATT-0/
https://ul.qucosa.de/api/qucosa%3A32100/attachment/ATT-0/
Autor:
Prohaska, Sonja J., Stadler, Peter F.
In order to describe a cell at molecular level, a notion of a “gene” is neither necessary nor helpful. It is sufficient to consider the molecules (i.e., chromosomes, transcripts, proteins) and their interactions to describe cellular processes. Th
Externí odkaz:
https://ul.qucosa.de/id/qucosa%3A31989
https://ul.qucosa.de/api/qucosa%3A31989/attachment/ATT-0/
https://ul.qucosa.de/api/qucosa%3A31989/attachment/ATT-0/
Genome-wide multiple sequence alignments (MSAs) are a necessary prerequisite for an increasingly diverse collection of comparative genomic approaches. Here we present a versatile method that generates high-quality MSAs for non-protein-coding sequence
Externí odkaz:
https://ul.qucosa.de/id/qucosa%3A31951
https://ul.qucosa.de/api/qucosa%3A31951/attachment/ATT-0/
https://ul.qucosa.de/api/qucosa%3A31951/attachment/ATT-0/
Autor:
Rose, Dominic, Jöris, Julian, Hackermüller, Jörg, Reiche, Kristin, Li, Qiang, Stadler, Peter F.
Teleost fishes share a duplication of their entire genomes. We report here on a computational survey of structured non-coding RNAs (ncRNAs) in teleost genomes, focusing on the fate of fish-specific duplicates. As in other metazoan groups, we find evi
Externí odkaz:
https://ul.qucosa.de/id/qucosa%3A31950
https://ul.qucosa.de/api/qucosa%3A31950/attachment/ATT-0/
https://ul.qucosa.de/api/qucosa%3A31950/attachment/ATT-0/
Autor:
Schuster, Peter, Stadler, Peter F.
RNA and protein molecules were found to be both templates for replication and specific catalysts for biochemical reactions. RNA molecules, although very difficult to obtain via plausible synthetic pathways under prebiotic conditions, are the only can
Externí odkaz:
https://ul.qucosa.de/id/qucosa%3A31947
https://ul.qucosa.de/api/qucosa%3A31947/attachment/ATT-0/
https://ul.qucosa.de/api/qucosa%3A31947/attachment/ATT-0/