Zobrazeno 1 - 10
of 21 891
pro vyhledávání: '"damage response"'
Autor:
Tamer A. Addissouky
Publikováno v:
Egyptian Liver Journal, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract Background Polyploidization, a process where cells acquire additional chromosome sets, is a unique characteristic of hepatocytes. This process has been increasingly recognized as an adaptive mechanism for maintaining liver function during ag
Externí odkaz:
https://doaj.org/article/56cf5f59661e469cb3806bb8a70eb985
Publikováno v:
Egyptian Journal of Medical Human Genetics, Vol 25, Iss 1, Pp 1-6 (2024)
Abstract Background Autism spectrum disorder (ASD) is a highly heritable neurodevelopmental disorder characterized by impaired social communication and repetitive behaviours. The genetic basis of ASD is complex and involves both rare variants with la
Externí odkaz:
https://doaj.org/article/1e137e0335b74b479f31ac8df0acc89a
Autor:
Seyed Esmaeil Ahmadi, Elahe Rahimian, Samira Rahimi, Bahman Zarandi, Mehran Bahraini, Maral Soleymani, Seyed Mehrab Safdari, Ashkan Shabannezhad, Niloofar Jaafari, Majid Safa
Publikováno v:
Biomarker Research, Vol 12, Iss 1, Pp 1-60 (2024)
Abstract The p53 protein, encoded by the TP53 gene, serves as a critical tumor suppressor, playing a vital role in maintaining genomic stability and regulating cellular responses to stress. Dysregulation of p53 is frequently observed in hematological
Externí odkaz:
https://doaj.org/article/edd454dcab5842c794282c615d36013f
Autor:
Yang Chen, Mingming Xiao, Yaqi Mo, Jinlu Ma, Yamei Han, Qing Li, Qinghua Zeng, Rebecca J. Boohaker, Joshua Fried, Yonghe Li, Han Wang, Bo Xu
Publikováno v:
Experimental Hematology & Oncology, Vol 13, Iss 1, Pp 1-19 (2024)
Abstract Background The activation of the DNA damage response (DDR) heavily relies on post-translational modifications (PTMs) of proteins, which play a crucial role in the prevention of genetic instability and tumorigenesis. Among these PTMs, palmito
Externí odkaz:
https://doaj.org/article/774e4c330964480d9ada5f488ef383f3
Autor:
Ruiqiu Zhu, Mingyue Li, Difan Wang, Chengzhi Liu, Liwei Xie, Yinyin Yang, Xuhao Gu, Kui Zhao, Ye Tian, Shang Cai
Publikováno v:
Molecular Medicine, Vol 30, Iss 1, Pp 1-17 (2024)
Abstract Background Radiation-induced intestinal injury (RIII) interrupts the scheduled processes of abdominal and pelvic radiotherapy (RT) and compromises the quality of life of cancer survivors. However, the specific regulators and mechanisms under
Externí odkaz:
https://doaj.org/article/966b0e265d814b8fa2708fda4809fbbd
Autor:
Yuhui Han, Wenjiong Sheng, Xiuxin Liu, Haide Liu, Xinyu Jia, Honghui Li, Changyuan Wang, Bin Wang, Tao Hu, Yanchao Ma
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract As one of the most common malignancies, colorectal cancer (CRC) usually starts with a benign lesion and accumulates DNA damage as it progresses to full-fledged cancer. Glycyrrhizin (GL) has been found to alleviate tumor growth and inflammati
Externí odkaz:
https://doaj.org/article/0cf42e116e3c44ee8e9fcb2a2c823d08
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract This study aimed to investigate whether the plant DNA damage levels and DNA damage response (DDR) are regulated during Agrobacterium infection and potentially manipulated by Agrobacterium to facilitate T-DNA integration. We investigated the
Externí odkaz:
https://doaj.org/article/2b55dcf9b80e4dfaafa4d0e1da100bf7
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-18 (2024)
Abstract The DNA damage response is a highly conserved protective mechanism that enables cells to cope with various lesions in the genome. Extensive studies across different eukaryotic cells have identified the crucial roles played by components requ
Externí odkaz:
https://doaj.org/article/9e4b3efb26ad4166a50e46d6622e2966
Autor:
Haihua Yuan, Renjie Cai, Biying Chen, Qian Wang, Mengting Wang, Junyi An, Weishu An, Ye Tao, Jianxiu Yu, Bin Jiang, Yanjie Zhang, Ming Xu
Publikováno v:
Molecular Oncology, Vol 18, Iss 9, Pp 2314-2330 (2024)
Androgen‐regulated DNA damage response (DDR) is one of the essential mechanisms in prostate cancer (PCa), a hormone‐sensitive disease. The heterogeneous nuclear ribonucleoprotein K (hnRNPK)‐homology splicing regulatory protein known as far upst
Externí odkaz:
https://doaj.org/article/9a39442787ce423ba7555c833b7e0f53
Autor:
Jiayi Li, Ziqi Jia, Lin Dong, Heng Cao, Yansong Huang, Hengyi Xu, Zhixuan Xie, Yiwen Jiang, Xiang Wang, Jiaqi Liu
Publikováno v:
Biomarker Research, Vol 12, Iss 1, Pp 1-32 (2024)
Abstract DNA damage response (DDR) deficiency has been one of the emerging targets in treating breast cancer in recent years. On the one hand, DDR coordinates cell cycle and signal transduction, whose dysfunction may lead to cell apoptosis, genomic i
Externí odkaz:
https://doaj.org/article/022406c0024840c49cd64f88da50a85b