Zobrazeno 1 - 10
of 495
pro vyhledávání: '"dalcetrapib"'
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Muthiah Vaduganathan, John Fanikos, Hessam Kakavand, Manuel Monreal, Deepak L. Bhatt, Sahil A. Parikh, Isaac Dreyfus, Gregg W. Stone, Peter Libby, Behnood Bikdeli, Benjamin W. Van Tassell, Harlan M. Krumholz, Samuel Z. Goldhaber, Hamid Ariannejad, David Jiménez, Aakriti Gupta, Gregory Piazza, Mahesh V. Madhavan, Gregory Y.H. Lip, Dave L. Dixon, Maryam Aghakouchakzadeh, Parham Sadeghipour, Azita Hajhossein Talasaz
Publikováno v:
Journal of the American College of Cardiology
Coronavirus disease-2019 (COVID-19) is associated with systemic inflammation, endothelial activation, and multiorgan manifestations. Lipid-modulating agents may be useful in treating patients with COVID-19. These agents may inhibit viral entry by lip
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3721f970ef56224a197e57d83090f783
http://europepmc.org/articles/PMC8504484
http://europepmc.org/articles/PMC8504484
Autor:
Rong Shi, Fouzia Laghrissi-Thode, Eric J. Niesor, Guy Boivin, Nathalie Goyette, Véronique Lavoie, Marie-Ève Picard, Eric Rhéaume, Jean-Claude Tardif, Anne Perez
Publikováno v:
ACS Omega, Vol 6, Iss 25, Pp 16584-16591 (2021)
ACS Omega
ACS Omega
The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) 3CL protease is a promising target for inhibition of viral replication by interaction with a cysteine residue (Cys145) at its catalytic site. Dalcetrapib exerts its lipid-modulating eff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::581567f984d32bf4aa0e708c4335f25c
https://doi.org/10.1021/acsomega.1c01797
https://doi.org/10.1021/acsomega.1c01797
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Sheng-Ping Wang, Erin Daniels, Ying Chen, Jose Castro-Perez, Haihong Zhou, Karen O. Akinsanya, Stephen F. Previs, Thomas P. Roddy, Douglas G. Johns
Publikováno v:
Journal of Lipid Research, Vol 54, Iss 10, Pp 2858-2865 (2013)
Cholesteryl ester transfer protein (CETP) transfers cholesteryl ester and triglyceride between HDL and apoB-containing lipoproteins. Anacetrapib (ANA), a reversible inhibitor of CETP, raises HDL cholesterol and lowers LDL cholesterol in dyslipidemic
Externí odkaz:
https://doaj.org/article/03111596da4743d3967c09a8c2bd6f4b
Publikováno v:
Clinica Chimica Acta. 510:733-740
Dyslipidemia is associated with atherosclerosis and cardiovascular disease development, posing serious risks to human health. Cholesteryl ester transfer protein (CETP) is responsible for exchange of neutral lipids, such as cholesteryl ester and TG, b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f15175263d19951d47e94f136604076
https://doi.org/10.1016/j.cca.2020.09.012
https://doi.org/10.1016/j.cca.2020.09.012
Publikováno v:
Xenobiotica. 51:82-87
We investigated the influence of multiple oral administration on the accumulation of dalcetrapib (JTT-705/RO4607381), a novel cholesteryl ester transfer protein inhibitor, in rats. It is well known that orally administered dalcetrapib is rapidly hydr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bff89d6444e0caa6caf9b9e709dc42b7
https://doi.org/10.1080/00498254.2020.1809030
https://doi.org/10.1080/00498254.2020.1809030
Publikováno v:
Xenobiotica. 51:31-39
Targeted covalent inhibitors designed to bind covalently to a specific molecular target have recently been a focus of drug development. Among these inhibitors, thiol compounds bind covalently to endogenous thiols in the body through a process involvi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f925c00a8206ddc8cf0bc5e82c4fa94
https://doi.org/10.1080/00498254.2020.1805816
https://doi.org/10.1080/00498254.2020.1805816
Publikováno v:
Organic Process Research & Development. 24:977-987
peer-reviewed The full text of this article will not be available in ULIR until the embargo expires on the 14/04/2021 This work aims to transfer the fast dissolution performances of drug nanosuspensions into the solid state via a carrier particle-med
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc7f1557c99e761e37f8f5134f536f33
https://doi.org/10.1021/acs.oprd.9b00460
https://doi.org/10.1021/acs.oprd.9b00460
Autor:
Donald M. Black, Taufiq Salahuddin, Jean-Claude Tardif, Lawrence A. Leiter, David Kallend, Philip J. Barter, Eran Leitersdorf, Stephen J. Nicholls, Christie M. Ballantyne, Anders G. Olsson, Prediman K. Shah, Gregory G. Schwartz, John Kittelson
Publikováno v:
American Heart Journal. 221:60-66
Background High-density lipoprotein cholesterol (HDL-C) concentration is inversely related to risk of major adverse cardiovascular events (MACE) in epidemiologic studies but is a poorer predictor of MACE in patients with established coronary heart di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7a5f308cff470276ad34fa952b3bc87
https://doi.org/10.1016/j.ahj.2019.12.003
https://doi.org/10.1016/j.ahj.2019.12.003