Opposing effects of the purinergic P2X7 receptor on seizures in neurons and microglia in male mice.

Autor: Alves M; Department of Physiology & Medical Physics, RCSI University of Medicine & Health Sciences, Dublin D02 YN77, Ireland., Gil B; Department of Physiology & Medical Physics, RCSI University of Medicine & Health Sciences, Dublin D02 YN77, Ireland., Villegas-Salmerón J; Department of Physiology & Medical Physics, RCSI University of Medicine & Health Sciences, Dublin D02 YN77, Ireland; FutureNeuro, SFI Research Centre for Chronic and Rare Neurological Diseases, RCSI University of Medicine and Health Sciences, Dublin D02 YN77, Ireland; The SFI Centre for Research Training in Genomics Data Science, RCSI University of Medicine & Health Sciences, Dublin D02 YN77, Ireland., Salari V; Department of Neurosciences, Biomedicine and Movement Sciences, School of Medicine, University of Verona, 37134 Verona, Italy., Martins-Ferreira R; Epigenetics and Immune Disease Group, Josep Carreras Research Institute (IJC), 08916 Badalona, Barcelona, Spain; Immunogenetics Laboratory, Molecular Pathology and Immunology, Instituto de Ciências Biomédicas Abel Salazar - Universidade do Porto (ICBAS-UP), Rua Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal; Autoimmunity and Neuroscience Group, UMIB - Unit for Multidisciplinary Research in Biomedicine, ICBAS - School of Medicine and Biomedical Sciences, University of Porto, Porto, Portugal; ITR - Laboratory for Integrative and Translational Research in Population Health, Porto, Portugal., Arribas Blázquez M; Department of Pharmacology and Toxicology, Veterinary Faculty, Universidad Complutense de Madrid, Avda. Puerta de Hierro s/n, 28040 Madrid, Spain., Menéndez Méndez A; Department of Physiology & Medical Physics, RCSI University of Medicine & Health Sciences, Dublin D02 YN77, Ireland; Department of Medicine, Faculty of Biomedical and Health Sciences, Universidad Europea de Madrid, 28670, Villaviciosa de Odon, Spain., Da Rosa Gerbatin R; Department of Physiology & Medical Physics, RCSI University of Medicine & Health Sciences, Dublin D02 YN77, Ireland; FutureNeuro, SFI Research Centre for Chronic and Rare Neurological Diseases, RCSI University of Medicine and Health Sciences, Dublin D02 YN77, Ireland., Smith J; Department of Physiology & Medical Physics, RCSI University of Medicine & Health Sciences, Dublin D02 YN77, Ireland; FutureNeuro, SFI Research Centre for Chronic and Rare Neurological Diseases, RCSI University of Medicine and Health Sciences, Dublin D02 YN77, Ireland., de Diego-Garcia L; Department of Physiology & Medical Physics, RCSI University of Medicine & Health Sciences, Dublin D02 YN77, Ireland; Ocupharm Research Group, Faculty of Optics and Optometry, Complutense University of Madrid, Avda. Arcos de Jalon, 118 (28037), Madrid, Spain., Conte G; Department of Physiology & Medical Physics, RCSI University of Medicine & Health Sciences, Dublin D02 YN77, Ireland., Sierra-Marquez J; Walther Straub Institute of Pharmacology and Toxicology, Faculty of Medicine, Ludwig-Maximilians-Universität München, Munich, Germany; Laboratorio Cajal de Circuitos Corticales (CTB), Centro de Tecnología Biomédica, Universidad Politécnica de Madrid, Campus Montegancedo S/N, Pozuelo de Alarcon, 28223 Madrid, Spain; Instituto Cajal, Consejo Superior de Investigaciones Científicas (CSIC), Madrid 28002, Spain; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, Instituto de Salud Carlos III, Madrid 28031, Spain., Merino Serrais P; Laboratorio Cajal de Circuitos Corticales (CTB), Centro de Tecnología Biomédica, Universidad Politécnica de Madrid, Campus Montegancedo S/N, Pozuelo de Alarcon, 28223 Madrid, Spain., Mitra M; Department of Physiology & Medical Physics, RCSI University of Medicine & Health Sciences, Dublin D02 YN77, Ireland., Fernandez Martin A; Department of Physiology & Medical Physics, RCSI University of Medicine & Health Sciences, Dublin D02 YN77, Ireland., Wang Y; Department of Physiology & Medical Physics, RCSI University of Medicine & Health Sciences, Dublin D02 YN77, Ireland; College of Pharmaceutical Sciences, Soochow University, Suzhou, Jiangsu 215123, China., Kesavan J; Department of Physiology & Medical Physics, RCSI University of Medicine & Health Sciences, Dublin D02 YN77, Ireland; FutureNeuro, SFI Research Centre for Chronic and Rare Neurological Diseases, RCSI University of Medicine and Health Sciences, Dublin D02 YN77, Ireland., Melia C; Department of Physiology & Medical Physics, RCSI University of Medicine & Health Sciences, Dublin D02 YN77, Ireland; VivoArchitect, Route de la Corniche 5, 1066 Epalinges, Vaud, Switzerland., Parras A; Department of Physiology & Medical Physics, RCSI University of Medicine & Health Sciences, Dublin D02 YN77, Ireland., Beamer E; Department of Physiology & Medical Physics, RCSI University of Medicine & Health Sciences, Dublin D02 YN77, Ireland; School of Science and Technology, Nottingham Trent University, Nottingham, UK., Zimmer B; Walther Straub Institute of Pharmacology and Toxicology, Faculty of Medicine, Ludwig-Maximilians-Universität München, Munich, Germany., Heiland M; Department of Physiology & Medical Physics, RCSI University of Medicine & Health Sciences, Dublin D02 YN77, Ireland; FutureNeuro, SFI Research Centre for Chronic and Rare Neurological Diseases, RCSI University of Medicine and Health Sciences, Dublin D02 YN77, Ireland., Cavanagh B; Cellular and Molecular Imaging Core, Royal College of Surgeons in Ireland, 123 St. Stephen's Green, Dublin 2, Ireland., Parcianello Cipolat R; Department of Physiology & Medical Physics, RCSI University of Medicine & Health Sciences, Dublin D02 YN77, Ireland; FutureNeuro, SFI Research Centre for Chronic and Rare Neurological Diseases, RCSI University of Medicine and Health Sciences, Dublin D02 YN77, Ireland., Morgan J; Department of Physiology & Medical Physics, RCSI University of Medicine & Health Sciences, Dublin D02 YN77, Ireland; Division of Developmental Biology and Medicine, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, M13 9PL, UK., Teng X; College of Pharmaceutical Sciences, Soochow University, Suzhou, Jiangsu 215123, China., Prehn JHM; Department of Physiology & Medical Physics, RCSI University of Medicine & Health Sciences, Dublin D02 YN77, Ireland; FutureNeuro, SFI Research Centre for Chronic and Rare Neurological Diseases, RCSI University of Medicine and Health Sciences, Dublin D02 YN77, Ireland., Fabene PF; Department of Neurosciences, Biomedicine and Movement Sciences, School of Medicine, University of Verona, 37134 Verona, Italy; Section of Anatomy and Histology, Department of Neurosciences, Biomedicine, and Movement Science, Faculty of Medicine, University of Verona, Verona, Italy; Section of Innovation Biomedicine, Department of Engineering for Innovation Medicine, Faculty of Medicine, University of Verona, Verona, Italy., Bertini G; Department of Neurosciences, Biomedicine and Movement Sciences, School of Medicine, University of Verona, 37134 Verona, Italy., Artalejo AR; Department of Pharmacology and Toxicology, Veterinary Faculty, Universidad Complutense de Madrid, Avda. Puerta de Hierro s/n, 28040 Madrid, Spain., Ballestar E; Epigenetics and Immune Disease Group, Josep Carreras Research Institute (IJC), 08916 Badalona, Barcelona, Spain; Epigenetics in Inflammatory and Metabolic Diseases Laboratory, Health Science Center (HSC), East China Normal University (ECNU), Shanghai 200241, China., Nicke A; Walther Straub Institute of Pharmacology and Toxicology, Faculty of Medicine, Ludwig-Maximilians-Universität München, Munich, Germany., Olivos-Oré LA; Department of Pharmacology and Toxicology, Veterinary Faculty, Universidad Complutense de Madrid, Avda. Puerta de Hierro s/n, 28040 Madrid, Spain., Connolly NMC; Department of Physiology & Medical Physics, RCSI University of Medicine & Health Sciences, Dublin D02 YN77, Ireland; FutureNeuro, SFI Research Centre for Chronic and Rare Neurological Diseases, RCSI University of Medicine and Health Sciences, Dublin D02 YN77, Ireland., Henshall DC; Department of Physiology & Medical Physics, RCSI University of Medicine & Health Sciences, Dublin D02 YN77, Ireland; FutureNeuro, SFI Research Centre for Chronic and Rare Neurological Diseases, RCSI University of Medicine and Health Sciences, Dublin D02 YN77, Ireland., Engel T; Department of Physiology & Medical Physics, RCSI University of Medicine & Health Sciences, Dublin D02 YN77, Ireland; FutureNeuro, SFI Research Centre for Chronic and Rare Neurological Diseases, RCSI University of Medicine and Health Sciences, Dublin D02 YN77, Ireland. Electronic address: tengel@rcsi.ie.

Publikováno v: Brain, behavior, and immunity [Brain Behav Immun] 2024 Aug; Vol. 120, pp. 121-140. Date of Electronic Publication: 2024 May 20.

Immunoproteasome deficiency results in age-dependent development of epilepsy.

Autor: Leister H; Institute for Medical Microbiology and Hygiene, Philipps-University, 35043 Marburg, Germany., Krause FF; Institute for Medical Microbiology and Hygiene, Philipps-University, 35043 Marburg, Germany., Gil B; Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, University of Medicine and Health Sciences, D02 YN77 Dublin, Ireland., Prus R; Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, University of Medicine and Health Sciences, D02 YN77 Dublin, Ireland., Prus I; Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, University of Medicine and Health Sciences, D02 YN77 Dublin, Ireland., Hellhund-Zingel A; Institute for Medical Microbiology and Hygiene, Philipps-University, 35043 Marburg, Germany., Mitra M; Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, University of Medicine and Health Sciences, D02 YN77 Dublin, Ireland., Da Rosa Gerbatin R; FutureNeuro, SFI Research Centre for Chronic and Rare Neurological Diseases, Royal College of Surgeons in Ireland, University of Medicine and Health Sciences, D02 YN77 Dublin, Ireland., Delanty N; FutureNeuro, SFI Research Centre for Chronic and Rare Neurological Diseases, Royal College of Surgeons in Ireland, University of Medicine and Health Sciences, D02 YN77 Dublin, Ireland.; Department of Neurology, Beaumont Hospital, D09V2N0 Dublin, Ireland., Beausang A; Department of Neuropathology, Beaumont Hospital, D09V2N0 Dublin, Ireland., Brett FM; Department of Neuropathology, Beaumont Hospital, D09V2N0 Dublin, Ireland., Farrell MA; Department of Neuropathology, Beaumont Hospital, D09V2N0 Dublin, Ireland., Cryan J; Department of Neuropathology, Beaumont Hospital, D09V2N0 Dublin, Ireland., O'Brien DF; Department of Neurosurgery, Beaumont Hospital, D09V2N0 Dublin, Ireland., Henshall DC; Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, University of Medicine and Health Sciences, D02 YN77 Dublin, Ireland.; FutureNeuro, SFI Research Centre for Chronic and Rare Neurological Diseases, Royal College of Surgeons in Ireland, University of Medicine and Health Sciences, D02 YN77 Dublin, Ireland., Helmprobst F; Institute of Neuropathology, Philipps-University, 35043 Marburg, Germany.; Core Facility for Mouse Pathology and Electron Microscopy, Philipps-University, 35043 Marburg, Germany., Pagenstecher A; Institute of Neuropathology, Philipps-University, 35043 Marburg, Germany.; Core Facility for Mouse Pathology and Electron Microscopy, Philipps-University, 35043 Marburg, Germany., Steinhoff U; Institute for Medical Microbiology and Hygiene, Philipps-University, 35043 Marburg, Germany., Visekruna A; Institute for Medical Microbiology and Hygiene, Philipps-University, 35043 Marburg, Germany., Engel T; Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, University of Medicine and Health Sciences, D02 YN77 Dublin, Ireland.; FutureNeuro, SFI Research Centre for Chronic and Rare Neurological Diseases, Royal College of Surgeons in Ireland, University of Medicine and Health Sciences, D02 YN77 Dublin, Ireland.

Publikováno v: Brain communications [Brain Commun] 2024 Jan 29; Vol. 6 (1), pp. fcae017. Date of Electronic Publication: 2024 Jan 29 (Print Publication: 2024).

Neuropharmacological insight into preventive intervention in posttraumatic epilepsy based on regulating glutamate homeostasis.

Autor: Gao, Yuan^1,2 (AUTHOR), Liu, Ning¹ (AUTHOR), Chen, Juan¹ (AUTHOR), Zheng, Ping¹ (AUTHOR), Niu, Jianguo³ (AUTHOR), Tang, Shengsong² (AUTHOR), Peng, Xiaodong¹ (AUTHOR), Wu, Jing¹ (AUTHOR) 13895308035@163.com, Yu, Jianqiang¹ (AUTHOR) yujqlab@163.com, Ma, Lin^1,3 (AUTHOR) malin_ky@163.com

Publikováno v: CNS Neuroscience & Therapeutics. Sep2023, Vol. 29 Issue 9, p2430-2444. 15p.

Metabolic Signature of Energy Metabolism Alterations and Excess Nitric Oxide Production in Culture Media Correlate with Low Human Embryo Quality and Unsuccessful Pregnancy.

Autor: Pallisco, Romina¹ (AUTHOR), Lazzarino, Giacomo² (AUTHOR), Bilotta, Gabriele² (AUTHOR), Marroni, Francesca² (AUTHOR), Mangione, Renata³ (AUTHOR), Saab, Miriam Wissam⁴ (AUTHOR), Brundo, Maria Violetta⁵ (AUTHOR), Pittalà, Alessandra⁴ (AUTHOR), Caruso, Giuseppe⁶ (AUTHOR), Capoccia, Elena² (AUTHOR), Lazzarino, Giuseppe^4,7 (AUTHOR) lazzarig@unict.it, Tavazzi, Barbara¹ (AUTHOR), Bilotta, Pasquale⁸ (AUTHOR), Amorini, Angela Maria⁴ (AUTHOR)

Publikováno v: International Journal of Molecular Sciences. Jan2023, Vol. 24 Issue 1, p890. 15p.

Antioxidant Therapy Reduces Oxidative Stress, Restores Na,K-ATPase Function and Induces Neuroprotection in Rodent Models of Seizure and Epilepsy: A Systematic Review and Meta-Analysis.

Autor: de Melo, Anderson Dutra, Freire, Victor Antonio Ferreira, Diogo, Ítalo Leonardo, Santos, Hérica de Lima, Barbosa, Leandro Augusto, de Carvalho, Luciana Estefani Drumond

Publikováno v: Antioxidants; Jul2023, Vol. 12 Issue 7, p1397, 27p