Cannabidiol prevents LPS-induced inflammation by inhibiting the NLRP3 inflammasome and iNOS activity in BV2 microglia cells via CB2 receptors and PPARγ.

Autor: Rodrigues FDS; Graduate Program in Biosciences, Federal University of Health Sciences of Porto Alegre (UFCSPA), Porto Alegre, Rio Grande do Sul, Brazil; Division of Biomedical and Life Sciences, Lancaster University, Lancaster, Lancashire, United Kingdom. Electronic address: fernandargois@gmail.com., Newton WR; Division of Biomedical and Life Sciences, Lancaster University, Lancaster, Lancashire, United Kingdom; MRC Centre for Medical Mycology, Exeter University, Exeter, United Kingdom. Electronic address: wn257@exeter.ac.uk., Tassinari ID; Division of Biomedical and Life Sciences, Lancaster University, Lancaster, Lancashire, United Kingdom; Graduate Program in Physiology, Institute of Basic Health Sciences (ICBS), Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, Rio Grande do Sul, Brazil. Electronic address: isatassinari@gmail.com., da Cunha Xavier FH; Thymus Research Laboratory, Oswaldo Cruz Institute (FIOCRUZ), Rio de Janeiro, Rio de Janeiro, Brazil. Electronic address: felipehcx@gmail.com., Marx A; Division of Biomedical and Life Sciences, Lancaster University, Lancaster, Lancashire, United Kingdom. Electronic address: marx.adel8@gmail.com., de Fraga LS; Graduate Program in Physiology, Institute of Basic Health Sciences (ICBS), Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, Rio Grande do Sul, Brazil. Electronic address: lucianof@ufrgs.br., Wright K; Division of Biomedical and Life Sciences, Lancaster University, Lancaster, Lancashire, United Kingdom. Electronic address: karen.wright@lancaster.ac.uk., Guedes RP; Graduate Program in Biosciences, Federal University of Health Sciences of Porto Alegre (UFCSPA), Porto Alegre, Rio Grande do Sul, Brazil; Graduate Program in Health Sciences, Federal University of Health Sciences of Porto Alegre (UFCSPA), Porto Alegre, Rio Grande do Sul, Brazil. Electronic address: renata.guedes@ufcspa.edu.br., Bambini-Jr V; Division of Biomedical and Life Sciences, Lancaster University, Lancaster, Lancashire, United Kingdom. Electronic address: v.bambini@lancaster.ac.uk.

Publikováno v: Neurochemistry international [Neurochem Int] 2024 Jul; Vol. 177, pp. 105769. Date of Electronic Publication: 2024 May 16.