A chromatin-regulated biphasic circuit coordinates IL-1β-mediated inflammation.

Autor: Fok ET; Department of Cell Biology, Faculty of Science, Radboud Institute for Molecular Life Sciences, Radboud University, Nijmegen, the Netherlands.; Department of Human Genetics, Radboud University Medical Center, Nijmegen, the Netherlands.; Lemba Therapeutics, Nijmegen, the Netherlands., Moorlag SJCFM; Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, the Netherlands., Negishi Y; Department of Cell Biology, Faculty of Science, Radboud Institute for Molecular Life Sciences, Radboud University, Nijmegen, the Netherlands.; Department of Human Genetics, Radboud University Medical Center, Nijmegen, the Netherlands., Groh LA; Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, the Netherlands., Dos Santos JC; Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, the Netherlands., Gräwe C; Department of Molecular Biology, Faculty of Science, Radboud Institute for Molecular Life Sciences, Oncode Institute, Radboud University, Nijmegen, the Netherlands., Monge VV; Lemba Therapeutics, Nijmegen, the Netherlands., Craenmehr DDD; Lemba Therapeutics, Nijmegen, the Netherlands., van Roosmalen M; Lemba Therapeutics, Nijmegen, the Netherlands., da Cunha Jolvino DP; Albert Einstein Research and Education Institute, Hospital Israelita Albert Einstein, São Paulo, Brazil.; Australian and New Zealand Intensive Care Research Centre, Monash University, Melbourne, Victoria, Australia., Migliorini LB; Albert Einstein Research and Education Institute, Hospital Israelita Albert Einstein, São Paulo, Brazil., Neto AS; Department of Critical Care Medicine, Hospital Israelita Albert Einstein, São Paulo, Brazil., Severino P; Albert Einstein Research and Education Institute, Hospital Israelita Albert Einstein, São Paulo, Brazil., Vermeulen M; Department of Molecular Biology, Faculty of Science, Radboud Institute for Molecular Life Sciences, Oncode Institute, Radboud University, Nijmegen, the Netherlands.; Division of Molecular Genetics, The Netherlands Cancer Institute, Amsterdam, the Netherlands., Joosten LAB; Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, the Netherlands.; Department of Medical Genetics, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania., Netea MG; Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, the Netherlands., Fanucchi S; Lemba Therapeutics, Nijmegen, the Netherlands., Mhlanga MM; Department of Cell Biology, Faculty of Science, Radboud Institute for Molecular Life Sciences, Radboud University, Nijmegen, the Netherlands. ikigai@mhlangalab.org.; Department of Human Genetics, Radboud University Medical Center, Nijmegen, the Netherlands. ikigai@mhlangalab.org.

Publikováno v: Nature genetics [Nat Genet] 2024 Jan; Vol. 56 (1), pp. 85-99. Date of Electronic Publication: 2023 Dec 13.