Using Selective Enzymes to Measure Noncanonical DNA Building Blocks: dUTP, 5-Methyl-dCTP, and 5-Hydroxymethyl-dCTP

Autor: Éva Viola Surányi, Viktória Perey-Simon, Rita Hirmondó, Tamás Trombitás, Latifa Kazzazy, Máté Varga, Beáta G. Vértessy, Judit Tóth

Publikováno v: Biomolecules, Vol 13, Iss 12, p 1801 (2023)

Cells maintain a fine-tuned balance of deoxyribonucleoside 5′-triphosphates (dNTPs), a crucial factor in preserving genomic integrity. Any alterations in the nucleotide pool’s composition or chemical modifications to nucleotides before their inco

Externí odkaz: https://doaj.org/article/246eae099bce49ec94da410c7a84d56b

Effect of induced dNTP pool imbalance on HIV-1 reverse transcription in macrophages

Autor: Caitlin Shepard, Joella Xu, Jessica Holler, Dong-Hyun Kim, Louis M. Mansky, Raymond F. Schinazi, Baek Kim

Publikováno v: Retrovirology, Vol 16, Iss 1, Pp 1-11 (2019)

Abstract Background Terminally differentiated/nondividing macrophages, a key target cell type of HIV-1, harbor extremely low dNTP concentrations established by a host dNTP triphosphohydrolase, SAM domain and HD domain containing protein 1 (SAMHD1). W

Externí odkaz: https://doaj.org/article/84f81dd739a245cab04437cb7403df15

The HMGB Protein KlIxr1, a DNA Binding Regulator of Kluyveromyces lactis Gene Expression Involved in Oxidative Metabolism, Growth, and dNTP Synthesis

Autor: Agustín Rico-Díaz, Aída Barreiro-Alonso, Cora Rey-Souto, Manuel Becerra, Mónica Lamas-Maceiras, M. Esperanza Cerdán, Ángel Vizoso-Vázquez

Publikováno v: Biomolecules, Vol 11, Iss 9, p 1392 (2021)

In the traditional fermentative model yeast Saccharomyces cerevisiae, ScIxr1 is an HMGB (High Mobility Group box B) protein that has been considered as an important regulator of gene transcription in response to external changes like oxygen, carbon s

Externí odkaz: https://doaj.org/article/6ee780fb387d4c5c9a7b8fcffeb15c0d

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A Yeast-Based Repurposing Approach for the Treatment of Mitochondrial DNA Depletion Syndromes Led to the Identification of Molecules Able to Modulate the dNTP Pool

Autor: Claudia Donnini, Micol Gilberti, Enrico Baruffini, Cristina Dallabona, Tiziana Lodi, Giulia di Punzio

Publikováno v: International Journal of Molecular Sciences
Volume 22
Issue 22
International Journal of Molecular Sciences, Vol 22, Iss 12223, p 12223 (2021)

Mitochondrial DNA depletion syndromes (MDS) are clinically heterogenous and often severe diseases, characterized by a reduction of the number of copies of mitochondrial DNA (mtDNA) in affected tissues. In the context of MDS, yeast has proved to be bo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::753a655ce8ed0b8714e29a5c3dab6aa2
http://europepmc.org/articles/PMC8621932