Zobrazeno 1 - 10
of 173
pro vyhledávání: '"dGTPase"'
Publikováno v:
Free Radical Biology and Medicine. 148:1-21
We measured the specific 8-oxo-dGTPase activity profile of the NCI-60 panel of malignant cell lines, and MTH1 protein levels in a subset of 16 lines. Their 8-oxo-dGTPase activity was compared to twelve publicly accessible MTH1 mRNA expression data ba
Autor:
C. Abraham, Gil Amitai, Adi Millman, Avigail Stokar-Avihail, Taya Fedorenko, Rotem Sorek, Nitzan Tal, Sarah Melamed, Erez Yirmiya, Azita Leavitt
DNA viruses and retroviruses need to consume large quantities of deoxynucleotides (dNTPs) when replicating within infected cells. The human antiviral factor SAMHD1 takes advantage of this vulnerability in the viral life cycle, and inhibits viral repl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::97a432663aacd2e99ced90034408ec36
https://doi.org/10.1101/2021.04.26.441389
https://doi.org/10.1101/2021.04.26.441389
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 1989 Jun 01. 86(11), 3949-3952.
Externí odkaz:
https://www.jstor.org/stable/33600
Autor:
Christopher O. Barnes, Aina E. Cohen, J. Song, E.L. Baxter, Nicholas K. Sauter, S.M. Soltis, Avram J. Holmes, Veeranagu Nagarajan, Jinwoo Ahn, Guowu Lin, Yijen L. Wu, Aaron S. Brewster, Guillermo Calero
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, vol 116, iss 19
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America
Significance While cellular dNTPases display broad activity toward dNTPs (e.g., SAMHD1), Escherichia coli (Ec)-dGTPase is the only known enzyme that specifically hydrolyzes dGTP. Here, we present methods for highly efficient, fixed-target X-ray free-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdf2f8be4137e7066f378ec0039dbbd8
https://escholarship.org/uc/item/4v75c32n
https://escholarship.org/uc/item/4v75c32n
Autor:
Guillermo Calero, J. Song, E.L. Baxter, Nagarajan, Avram J. Holmes, Nicholas K. Sauter, Aaron S. Brewster, M. Soltis, Guowu Lin, Yang Wu, Adam E. Cohen, Christopher O. Barnes, Jinwoo Ahn
Deoxynucleotide triphosphate triphosphyohydrolyases (dNTPases) play a critical role in cellular survival and DNA replication through the proper maintenance of cellular dNTP pools by hydrolyzing dNTPs into deoxynucleosides and inorganic triphosphate (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::684e7138a8e8d800d3b1c818a756cd7e
Publikováno v:
Expert Review of Proteomics. 12:97-107
Objective: In this study, we aimed to search for noninvasive predictive biomarkers for prenatal diagnosis of Down’s syndrome (DS). Methods: Maternal serum samples from five DS-affected pregnant women and five DS-unaffected women were analyzed by 2D
The VEGF/Rho GTPase signalling pathway: A promising target for anti-angiogenic/anti-invasion therapy
Autor:
Raymond M. Schiffelers, Gert Storm, Marc Symons, William M. Gallagher, Robert Kudernatsch, Robbert J. Kok, Annette T. Byrne, Roy van der Meel
Publikováno v:
Drug Discovery Today. 16:219-228
It has become increasingly apparent that current antiangiogenic therapy elicits modest effects in clinical settings. In addition, it remains challenging to treat cancer metastasis through antiangiogenic regimes. Rho GTPases are essential for vascular
Autor:
Luciana Renna, Stefano Mancuso, Giovanni Stefano, Marika Rossi, Federica Brandizzi, Susanna Pollastri, František Baluška, Elisa Azzarello
Publikováno v:
The Plant Journal. 64:790-799
ARF-GTPases are important proteins that control membrane trafficking events. Their activity is largely influenced by the interplay between guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs), which facilitate the activati
Autor:
Nicole Schneiderhan-Marra, Thomas O. Joos, Stefanie Rimmele, Peter Gierschik, Oliver Pötz, Michael Schmohl, Yoel Kloog
Publikováno v:
PROTEOMICS. 10:1716-1720
A miniaturized, bead-based protein-protein-interaction assay was developed to study the interaction of Rho GTPases with regulatory proteins. The setup, which uses only minute amounts of sample, was used to analyze small molecules that inhibit the int
Autor:
Alemayehu A. Gorfe
Publikováno v:
Current Medicinal Chemistry. 17:1-9
Ras GTPases are membrane-anchored molecular switches that mediate signaling pathways controlling a variety of cellular processes, including cell division and development. Despite their prominent role in many forms of cancer, little is known about the