Dual targeting and bioresponsive nano-PROTAC induced precise and effective lung cancer therapy

Autor: Xiaoling Guan, Xiaowei Xu, Yiwen Tao, Xiaohua Deng, Linlong He, Zhongxiao Lin, Jishuo Chang, Jionghua Huang, Dazhi Zhou, Xiyong Yu, Minyan Wei, Lingmin Zhang

Publikováno v: Journal of Nanobiotechnology, Vol 22, Iss 1, Pp 1-17 (2024)

Abstract Epigenetic regulation has emerged as a promising therapeutic strategy for lung cancer treatment, which can facilitate the antitumor responses by modulating epigenetic dysregulation of target proteins in lung cancer. The proteolysis-targeting

Externí odkaz: https://doaj.org/article/844e77478f364ceea0fb44ed6bbef605

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Degradation of BRD4 - a promising treatment approach not only for hematologic but also for solid cancer.

Autor: Bauer K; Ludwig Boltzmann Institute for Hematology and Oncology, Medical University of Vienna Austria.; Comprehensive Cancer Center, Medical University of Vienna Austria.; Department of Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna Austria., Berghoff AS; Department of Medicine I, Division of Oncology, Medical University of Vienna Austria., Preusser M; Comprehensive Cancer Center, Medical University of Vienna Austria.; Department of Medicine I, Division of Oncology, Medical University of Vienna Austria., Heller G; Comprehensive Cancer Center, Medical University of Vienna Austria.; Department of Medicine I, Division of Oncology, Medical University of Vienna Austria., Zielinski CC; Comprehensive Cancer Center, Medical University of Vienna Austria.; Department of Medicine I, Division of Oncology, Medical University of Vienna Austria., Valent P; Ludwig Boltzmann Institute for Hematology and Oncology, Medical University of Vienna Austria.; Comprehensive Cancer Center, Medical University of Vienna Austria.; Department of Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna Austria., Grunt TW; Ludwig Boltzmann Institute for Hematology and Oncology, Medical University of Vienna Austria.; Comprehensive Cancer Center, Medical University of Vienna Austria.; Department of Medicine I, Division of Oncology, Medical University of Vienna Austria.

Publikováno v: American journal of cancer research [Am J Cancer Res] 2021 Feb 01; Vol. 11 (2), pp. 530-545. Date of Electronic Publication: 2021 Feb 01 (Print Publication: 2021).