Výsledky vyhledávání - "cytotoxic RNAse"

Solution Structure of the Cytotoxic RNase 4 from Oocytes of Bullfrog Rana catesbeiana

Autor: Yun-Ru Pan, Chinpan Chen, Lih-Woan Chen, Chun-Hua Hsu, Ying-Jen Leu, You-Di Liao, Shih-Hsiung Wu

Publikováno v: Journal of Molecular Biology. 326:1189-1201

Cytotoxic ribonucleases with antitumor activity are mainly found in the oocytes and early embryos of frogs. Native RC-RNase 4 (RNase 4), consisting of 106 residues linked with four disulfide bridges, is a cytotoxic ribonuclease isolated from oocytes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::694ab58e6ea77b05968c2d768ddd65b1
https://doi.org/10.1016/s0022-2836(02)01472-9

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nteractions of the cytotoxic RNase A dimers with the cytosolic ribonuclease inhibitor

Autor: Naddeo, Mariarosaria, Vitagliano, Luigi, Russo, Aniello, Gotte, Giovanni, D'Alessio, Giuseppe, Sorrentino, Salvatore.

Publikováno v: FEBS letters
579 (2005): 2663–2668.
info:cnr-pdr/source/autori:Naddeo, Mariarosaria; Vitagliano, Luigi; Russo, Aniello; Gotte, Giovanni; D'Alessio, Giuseppe; Sorrentino, Salvatore./titolo:nteractions of the cytotoxic RNase A dimers with the cytosolic ribonuclease inhibitor./doi:/rivista:FEBS letters (Print)/anno:2005/pagina_da:2663/pagina_a:2668/intervallo_pagine:2663–2668/volume:579

RNase A dimers have been recently found to be endowed with some of the special, i.e., non-catalytic biol. activities of RNases, such as antitumor and aspermatogenic activities. These activities have been so far attributed to RNases which can escape t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=cnr_________::71c85a57615fd693be8a0b2ed02e6206
http://www.cnr.it/prodotto/i/13514

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Possible Mechanisms Of Improved Radiation Response By Cytotoxic Rnase, Onconase®, On A549 Human Lung Cancer Xenografts Of Nude Mice

Autor: Eun Ju Kim, Intae Lee, Kuslima Shogen, Alan M. Gewirtz, Dae Hong Kim, Anna Kalota, Jerry D. Glickson

Publikováno v: Oxygen Transport to Tissue XXVIII ISBN: 9780387717630

The cytotoxic RNase, Onconase (ONC), isolated from amphibian oocytes, was used to study its effect on the radiation response in A549 human NSCLC in vitro and in vivo. In cell culture studies, we found that ONC increased the radiation response by ONC-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::24e951680df3d8dad855013d1bee5955
https://doi.org/10.1007/978-0-387-71764-7_8

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Antitumor efficacy of the cytotoxic RNase, ranpirnase, on A549 human lung cancer xenografts of nude mice

Autor: Intae, Lee, Anna, Kalota, Alan M, Gewirtz, Kuslima, Shogen

Publikováno v: Anticancer research. 27(1A)

The cytotoxic RNase, ranpirnase (ONCONASE, ONC), may have promising therapeutic implication as an alternative for cisplatin for the treatment of lung cancer, due to inhibition of protein synthesis by t-RNA cleavage.A549 and NCI-H1975 human NSCLC cell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c336712157ddb84a4d5cc06cf4f79b5e
https://pubmed.ncbi.nlm.nih.gov/17352247

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Akademický článek

Possible mechanisms of improved radiation response by cytotoxic RNase, Onconase, on A549 human lung cancer xenografts of nude mice.

Autor: Kim DH; Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA., Kim EJ, Kalota A, Gewirtz AM, Glickson J, Shogen K, Lee I

Publikováno v: Advances in experimental medicine and biology [Adv Exp Med Biol] 2007; Vol. 599, pp. 53-9.

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