Zobrazeno 1 - 10
of 390
pro vyhledávání: '"cytosine deamination"'
Autor:
Siddhant Sethi, Yasuharu Takashima, Shigetaka Nakamura, Licheng Wan, Nozomi Honda, Kenzo Fujimoto
Publikováno v:
Current Issues in Molecular Biology, Vol 45, Iss 6, Pp 4687-4700 (2023)
Herein, we report the major factor for deamination reaction rate acceleration, i.e., hydrophilicity, by using various 5-substituted target cytosines and by carrying out deamination at high temperatures. Through substitution of the groups at the 5′-
Externí odkaz:
https://doaj.org/article/8887be9d1e7744c0a2cd85c3f4ac0e1c
Autor:
Yilin Shi, Huangxuan Shen
Publikováno v:
Frontiers in Genetics, Vol 14 (2023)
Stomach Adenocarcinoma (STAD) is a leading cause of death worldwide. Somatic Copy Number Alterations (SCNAs), which result in Homologous recombination (HR) deficiency in double-strand break repair, are associated with the progression of STAD. However
Externí odkaz:
https://doaj.org/article/a8beed9c58cf4ee09bf0577befddf06a
Autor:
Ashley A. Auerbach, Jordan T. Becker, Sofia N. Moraes, Seyed Arad Moghadasi, Jolene M. Duda, Daniel J. Salamango, Reuben S. Harris
Publikováno v:
mSphere, Vol 7, Iss 6 (2022)
ABSTRACT APOBEC3B is an innate immune effector enzyme capable of introducing mutations in viral genomes through DNA cytosine-to-uracil editing. Recent studies have shown that gamma-herpesviruses, such as Epstein-Barr virus (EBV), have evolved a poten
Externí odkaz:
https://doaj.org/article/a41bf03117264cc4867ed3105146f18f
Autor:
James W. Conrad, Mark L. Sowers, Dianne Y. Yap, Ellie Cherryhomes, B. Montgomery Pettitt, Kamil Khanipov, Lawrence C. Sowers
Publikováno v:
Biomolecules, Vol 13, Iss 9, p 1308 (2023)
Increased expression of the human telomere reverse transcriptase (hTERT) in tumors promotes tumor cell survival and diminishes the survival of patients. Cytosine-to-thymine (C-to-T) transition mutations (C250T or C228T) in the hTERT promoter create b
Externí odkaz:
https://doaj.org/article/4bc5f189d353409db9ab8edea379c2ed
Publikováno v:
BMC Medical Genomics, Vol 14, Iss 1, Pp 1-9 (2021)
Abstract Background Recently, a next-generation sequencing (NGS)-based method has been used for the successful detection of circulating tumor DNA (ctDNA) in various cancer types. Thus, the use of NGS on liquid biopsies will improve cancer diagnosis a
Externí odkaz:
https://doaj.org/article/6259cdfc4c3342a8a6ba7111a198598f
Autor:
Erika F. Rodriguez, Federico De Marchi, Parvez M. Lokhandwala, Deborah Belchis, Rena Xian, Christopher D. Gocke, James R. Eshleman, Peter Illei, Ming‐Tseh Li
Publikováno v:
Cancer Medicine, Vol 9, Iss 12, Pp 4386-4394 (2020)
Abstract Background Selective IDH1 and IDH2 inhibitors have been approved for targeted therapy of acute myeloid leukemia. Clinical trials for solid tumors with IDH1 and IDH2 (IDH1/2) mutations are ongoing. Reports of IDH1/2‐mutated non–small cell
Externí odkaz:
https://doaj.org/article/d4066f83fadc406b860f4b17fa765af8
Autor:
Marina Alexeeva, Marivi Nabong Moen, Xiang Ming Xu, Anette Rasmussen, Ingar Leiros, Finn Kirpekar, Arne Klungland, Lene Alsøe, Hilde Nilsen, Svein Bjelland
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Uracil arises in cellular DNA by cytosine (C) deamination and erroneous replicative incorporation of deoxyuridine monophosphate opposite adenine. The former generates C → thymine transition mutations if uracil is not removed by uracil-DNA glycosyla
Externí odkaz:
https://doaj.org/article/d7f045b476d94cb59da2ab03aa3d7809
Autor:
Vladislav Victorovich Khrustalev, Rajanish Giri, Tatyana Aleksandrovna Khrustaleva, Shivani Krishna Kapuganti, Aleksander Nicolaevich Stojarov, Victor Vitoldovich Poboinev
Publikováno v:
Frontiers in Microbiology, Vol 11 (2020)
Within 4 months of the ongoing COVID-19 pandemic caused by SARS-CoV-2, more than 250 nucleotide mutations have been detected in ORF1ab of the virus isolated from infected persons from different parts of the globe. These observations open up an obviou
Externí odkaz:
https://doaj.org/article/107060e6697340bb82a2660aba0b0bac
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