Zobrazeno 1 - 10
of 307
pro vyhledávání: '"cytoophidium"'
Publikováno v:
mLife, Vol 3, Iss 2, Pp 240-250 (2024)
Abstract Cytidine triphosphate synthase (CTPS) plays a pivotal role in the de novo synthesis of cytidine triphosphate (CTP), a fundamental building block for RNA and DNA that is essential for life. CTPS is capable of directly binding to all four nucl
Externí odkaz:
https://doaj.org/article/24b3fd2b11c24a5082fd27ce6a4462d2
Akademický článek
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Autor:
Yuanbing Zhang, Ji-Long Liu
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 18, p 10058 (2024)
The cytoophidium, composed mainly of CTP synthase (CTPS), is a newly discovered dynamic filamentous structure in various organisms such as archaea, bacteria, and humans. These filamentous structures represent a fascinating example of intracellular co
Externí odkaz:
https://doaj.org/article/a8a8ff4014ea4a46bd1d967e3b6062c9
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 18, p 10092 (2024)
The de novo synthesis of cytidine 5′-triphosphate (CTP) is catalyzed by the enzyme CTP synthase (CTPS), which is known to form cytoophidia across all three domains of life. In this study, we use the budding yeast Saccharomyces cerevisiae and the fi
Externí odkaz:
https://doaj.org/article/ac0cd276f4774228b9fc8a44059fa26a
Autor:
Guang-Ming Lu, Huan-Huan Hu, Chia-Chun Chang, Jiale Zhong, Xian Zhou, Chen-Jun Guo, Tianyi Zhang, Yi-Lan Li, Boqi Yin, Ji-Long Liu
Publikováno v:
Cell & Bioscience, Vol 13, Iss 1, Pp 1-16 (2023)
Abstract Background PRPP synthase (PRPS) transfers the pyrophosphate groups from ATP to ribose-5-phosphate to produce 5-phosphate ribose-1-pyrophosphate (PRPP), a key intermediate in the biosynthesis of several metabolites including nucleotides, dinu
Externí odkaz:
https://doaj.org/article/7f27df0d7dd448b29cad47f0feae8a41
Publikováno v:
eLife, Vol 12 (2023)
Obesity induced by high-fat diet (HFD) is a multi-factorial disease including genetic, physiological, behavioral, and environmental components. Drosophila has emerged as an effective metabolic disease model. Cytidine 5'-triphosphate synthase (CTPS) i
Externí odkaz:
https://doaj.org/article/642fa45a365f4f819a47f0889e71701b
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Introduction: Inosine monophosphate dehydrogenase 1 (IMPDH1) is a critical enzyme in the retina, essential for the correct functioning of photoreceptor cells. Mutations in IMPDH1 have been linked to autosomal dominant retinitis pigmentosa subtype 10
Externí odkaz:
https://doaj.org/article/8b8694f6b0af4ff2a33318a56a2ae235
Autor:
Shi-Qi Zhang, Ji-Long Liu
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 5, p 2575 (2024)
CTP synthase (CTPS) catalyzes the final step of de novo synthesis of CTP. CTPS was first discovered to form filamentous structures termed cytoophidia in Drosophila ovarian cells. Subsequent studies have shown that cytoophidia are widely present in ce
Externí odkaz:
https://doaj.org/article/43f01ddec81447eea63843b6810474fa
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 1, p 608 (2024)
Cytidine triphosphate synthase (CTPS) forms cytoophidia in all three domains of life. Here we focus on the function of cytoophidia in cell proliferation using Schizosaccharomyces pombe as a model system. We find that converting His359 of CTPS into Al
Externí odkaz:
https://doaj.org/article/9539518a37f3446fb339901cf2393e71
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 3, p 1453 (2024)
CTP synthase (CTPS), the rate-limiting enzyme in the de novo synthesis of CTP, assembles into a filamentous structure termed the cytoophidium. The Hippo pathway regulates cell proliferation and apoptosis. The relationship of the nucleotide metabolism
Externí odkaz:
https://doaj.org/article/d7a556c947ab474d9a4d9eea4f02b4d3