Zobrazeno 1 - 10
of 51
pro vyhledávání: '"cytolytic fusion proteins"'
Autor:
Neelakshi Mungra, Guillaume Vignaux, Jean Engohang-Ndong, Eden Padayachee, Jean De La Croix Ndong, Fleury Augustin Nsole Biteghe, Stefan Barth, Nyangone Ekome Toung Chalomie, Krupa Naran
Publikováno v:
Oncotarget
The epidermal growth factor receptor (EGFR) has been recognized as an important therapeutic target in oncology. It is commonly overexpressed in a variety of solid tumors and is critically involved in cell survival, proliferation, metastasis, and angi
Autor:
Precious Hlongwane, Neelakshi Mungra, Suresh Madheswaran, Olusiji A. Akinrinmade, Shivan Chetty, Stefan Barth
Publikováno v:
Biomedicines, Vol 6, Iss 2, p 72 (2018)
Cancer immunotherapy aims to selectively target and kill tumor cells whilst limiting the damage to healthy tissues. Controlled delivery of plant, bacterial and human toxins or enzymes has been shown to promote the induction of apoptosis in cancerous
Externí odkaz:
https://doaj.org/article/cc54a3a76d5f43a58bf8257e0236ef27
Autor:
Sandra Jordaan, Olusiji A. Akinrinmade, Thomas Nachreiner, Christian Cremer, Krupa Naran, Shivan Chetty, Stefan Barth
Publikováno v:
Biomedicines, Vol 6, Iss 1, p 28 (2018)
Targeted cancer therapy includes, amongst others, antibody-based delivery of toxic payloads to selectively eliminate tumor cells. This payload can be either a synthetic small molecule drug composing an antibody-drug conjugate (ADC) or a cytotoxic pro
Externí odkaz:
https://doaj.org/article/66c4f9f9103a4660be7438b5d9de26a3
Autor:
Mehmet Kemal Tur, Adebukola K. Daramola, Stefan Gattenlöhner, Marco Herling, Shivan Chetty, Stefan Barth
Publikováno v:
Biomedicines, Vol 5, Iss 4, p 59 (2017)
Targeted cancer immunotherapy is designed to selectively eliminate tumor cells without harming the surrounding healthy tissues. The death-associated protein kinases (DAPk) are a family of proapoptotic proteins that play a vital role in the regulation
Externí odkaz:
https://doaj.org/article/c81239a63d3d4979ae3dade26808e59b
Autor:
Olusiji A. Akinrinmade, Sandra Jordaan, Dmitrij Hristodorov, Radoslav Mladenov, Neelakshi Mungra, Shivan Chetty, Stefan Barth
Publikováno v:
Biomedicines, Vol 5, Iss 3, p 36 (2017)
Some of the most promising small molecule toxins used to generate antibody drug conjugates (ADCs) include anti-mitotic agents (e.g., auristatin and its derivatives) which are designed to attack cancerous cells at their most vulnerable state during mi
Externí odkaz:
https://doaj.org/article/b58b69018c914f209e1a2ad9b38d89fb
Autor:
Anna Bochicchio, Sandra Jordaan, Valeria Losasso, Shivan Chetty, Rodrigo Casasnovas Perera, Emiliano Ippoliti, Stefan Barth, Paolo Carloni
Publikováno v:
Biomedicines, Vol 5, Iss 1, p 9 (2017)
Targeted human cytolytic fusion proteins (hCFPs) are humanized immunotoxins for selective treatment of different diseases including cancer. They are composed of a ligand specifically binding to target cells genetically linked to a human apoptosis-ind
Externí odkaz:
https://doaj.org/article/84a6e6881deb49c7ace63c399f423782
Autor:
Neelakshi Mungra, Olusiji A. Akinrinmade, Suresh Madheswaran, Stefan Barth, Precious Hlongwane, Shivan Chetty
Publikováno v:
Biomedicines, Vol 6, Iss 2, p 72 (2018)
Biomedicines
Biomedicines
Cancer immunotherapy aims to selectively target and kill tumor cells whilst limiting the damage to healthy tissues. Controlled delivery of plant, bacterial and human toxins or enzymes has been shown to promote the induction of apoptosis in cancerous
Autor:
Marco Herling, Adebukola K. Daramola, Mehmet Kemal Tur, Stefan Barth, Stefan Gattenlöhner, Shivan Chetty
Publikováno v:
Biomedicines, Vol 5, Iss 4, p 59 (2017)
Biomedicines
Biomedicines
Targeted cancer immunotherapy is designed to selectively eliminate tumor cells without harming the surrounding healthy tissues. The death-associated protein kinases (DAPk) are a family of proapoptotic proteins that play a vital role in the regulation
Publikováno v:
Biomedicines. 5(3)
Chondroitin-sulfate proteoglycan 4 (CSPG4) is a transmembrane glycoprotein overexpressed on malignant cells in several cancer types with only limited expression on normal cells. CSPG4 is implicated in several signaling pathways believed to drive canc
Autor:
Stefan Barth, Sandra Jordaan, Peter E. van Bommel, Wijnand Helfrich, Iris Koopmans, Neelakshi Mungra, Shivan Chetty
Publikováno v:
Biomedicines
Chondroitin-sulfate proteoglycan 4 (CSPG4) is a transmembrane glycoprotein overexpressed on malignant cells in several cancer types with only limited expression on normal cells. CSPG4 is implicated in several signaling pathways believed to drive canc