Cell motility and migration as determinants of stem cell efficacy

Autor: Danielyan, Lusine, Schwab, Matthias, Krueger, Marcel A., Calaminus, Carsten, Naumann, Ulrike, Winter, Stefan, Schaeffeler, Elke, Spogis, Annett, Beer-Hammer, Sandra, Neher, Jonas J., Spohn, Gabriele, Kretschmer, Anja, Siegel, Georg, Krämer-Albers, Eva-Maria, Barth, Kerstin, Lee, Hong Jun, Kim, Seung U., Frey, William H., Claussen, Claus D., Hermann, Dirk M., Doeppner, Thorsten R., Seifried, Erhard, Gleiter, Christoph H., Brawek, Bianca, Northoff, Hinnak, Schäfer, Richard, Garaschuk, Olga, Asavapanumas, Nithi, Buadze, Marine, Lourhmati, Ali, Wendel, Hans-Peter, Avci-Adali, Meltem

Publikováno v: EBioMedicine, Vol 60, Iss, Pp 102989-(2020)
EBioMedicine
EBioMedicine 60, 102989-(2020). doi:10.1016/j.ebiom.2020.102989

Background: Stem cells‘ (SC) functional heterogeneity and its poorly understood aetiology impedes clinical development of cell-based therapies in regenerative medicine and oncology. Recent studies suggest a strong correlation between the SC migrati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::3667662807e8d4d6581fe2cfe0ec57af
http://www.sciencedirect.com/science/article/pii/S2352396420303650

Lysophosphatidic Acid Receptor Is a Functional Marker of Adult Hippocampal Precursor Cells

Autor: Muhammad Ichwan, Gerd Kempermann, Alex M. Sykes, Susann Ruhwald, Tara L. Walker, Steffen Vogler, Rupert W. Overall, Klaus Fabel, Daniela Lasse

Publikováno v: Stem Cell Reports
Stem Cell Reports, Vol 6, Iss 4, Pp 552-565 (2016)
Stem cell reports 6(4), 552-565 (2016). doi:10.1016/j.stemcr.2016.03.002

Summary Here, we show that the lysophosphatidic acid receptor 1 (LPA1) is expressed by a defined population of type 1 stem cells and type 2a precursor cells in the adult mouse dentate gyrus. LPA1, in contrast to Nestin, also marks the quiescent stem

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70674d519c5669d2edd766089c10578a

Nkx6-1 controls the identity and fate of red nucleus and oculomotor neurons in the mouse midbrain

Autor: Dietrich Trümbach, Eduardo Puelles, Antonio Simeone, Daniela Omodei, Maike Sander, Michela Di Salvio, Nilima Prakash, Johan Ericson, Lori Sussel, Wolfgang Wurst, Kristine K. Freude

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname
Development (Camb.) 136 (2009): 2545–2555. doi:10.1242/dev.031781
info:cnr-pdr/source/autori:Prakash N, Puelles E, Freude K, Trümbach D, Omodei D, Di Salvio M, Sussel L, Ericson J, Sander M, Simeone A, Wurst W/titolo:Nkx6-1 controls the identity and fate of red nucleus and oculomotor neurons in the mouse midbrain/doi:10.1242%2Fdev.031781/rivista:Development (Camb.)/anno:2009/pagina_da:2545/pagina_a:2555/intervallo_pagine:2545–2555/volume:136
Development 136(15), 2545-2555 (2009). doi:10.1242/dev.031781

Little is known about the cues controlling the generation of motoneuron populations in the mammalian ventral midbrain. We show that Otx2 provides the crucial anterior-posterior positional information for the generation of red nucleus neurons in the m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b36ed553eed542e78bf6f98cb412c296
https://doi.org/10.1242/dev.031781

Stem Cell–Derived Photoreceptor Transplants Differentially Integrate Into Mouse Models of Cone-Rod Dystrophy

Autor: Marius Ader, Peter Carmeliet, Oliver Borsch, Stylianos Michalakis, Denis Corbeil, Peter Cimalla, Jochen Haas, Edmund Koch, Mike O. Karl, Manuela Völkner, Praveen Vasudevan, Tiago Santos-Ferreira

Publikováno v: Investigative ophthalmology & visual science 57(7), 3509 (2016). doi:10.1167/iovs.16-19087

PURPOSE. Preclinical studies on photoreceptor transplantation provided evidence for restoration of visual function with pluripotent stem cells considered as a potential source for sufficient amounts of donor material. Adequate preclinical models repr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52d7bf98ed3a976571f23e31c2f9e61b
https://doi.org/10.1167/iovs.16-19087

Glial cells in adult neurogenesis

Autor: Gerd Kempermann, Wim Van den Broeck, Joachim Morrens

Publikováno v: Glia 60(2), 159-174 (2011). doi:10.1002/glia.21247

Adult neurogenesis is an exceptional feature of the adult brain and in an intriguing way bridges between neuronal and glial neurobiology. Essentially, all classes of glial cells are directly or indirectly linked to this process. Cells with astrocytic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9dcd8e1359d841915c1c11885a16ec81
https://pubmed.ncbi.nlm.nih.gov/22076934