Výsledky vyhledávání - "cytology [Motor Neurons]"

Nkx6-1 controls the identity and fate of red nucleus and oculomotor neurons in the mouse midbrain

Autor: Dietrich Trümbach, Eduardo Puelles, Antonio Simeone, Daniela Omodei, Maike Sander, Michela Di Salvio, Nilima Prakash, Johan Ericson, Lori Sussel, Wolfgang Wurst, Kristine K. Freude

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname
Development (Camb.) 136 (2009): 2545–2555. doi:10.1242/dev.031781
info:cnr-pdr/source/autori:Prakash N, Puelles E, Freude K, Trümbach D, Omodei D, Di Salvio M, Sussel L, Ericson J, Sander M, Simeone A, Wurst W/titolo:Nkx6-1 controls the identity and fate of red nucleus and oculomotor neurons in the mouse midbrain/doi:10.1242%2Fdev.031781/rivista:Development (Camb.)/anno:2009/pagina_da:2545/pagina_a:2555/intervallo_pagine:2545–2555/volume:136
Development 136(15), 2545-2555 (2009). doi:10.1242/dev.031781

Little is known about the cues controlling the generation of motoneuron populations in the mammalian ventral midbrain. We show that Otx2 provides the crucial anterior-posterior positional information for the generation of red nucleus neurons in the m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b36ed553eed542e78bf6f98cb412c296
https://doi.org/10.1242/dev.031781

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Granulin Knock Out Zebrafish Lack Frontotemporal Lobar Degeneration and Neuronal Ceroid Lipofuscinosis Pathology

Autor: Elisabeth Kremmer, Barbara Solchenberger, Christian Haass, Bettina Schmid, Claire Russell

Publikováno v: PLoS ONE
PLoS One
PLoS ONE, Vol 10, Iss 3, p e0118956 (2015)
PLoS ONE 10:e0118956 (2015)
PLOS ONE 10(3), e0118956 (2015). doi:10.1371/journal.pone.0118956

Loss of function mutations in granulin (GRN) are linked to two distinct neurological disorders, frontotemporal lobar degeneration (FTLD) and neuronal ceroid lipofuscinosis (NCL). It is so far unknown how a complete loss of GRN in NCL and partial loss

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::572469d8ce8c9475334e57540f868318
http://europepmc.org/articles/PMC4365039

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Internalization and retrograde axonal trafficking of tetanus toxin in motor neurons and trans-synaptic propagation at central synapses exceed those of its C-terminal-binding fragments

Autor: Ovsepian, Saak V, Ovespian, Saak V, Bodeker, MacDara, O'Leary, Valerie B, Lawrence, Gary W, Oliver Dolly, J.

Publikováno v: Brain structure & function 220(3), 1825-1838 (2015). doi:10.1007/s00429-015-1004-0

The prominent tropism of tetanus toxin (TeTx) towards peripheral nerves with retrograde transport and transfer to central neurons render it an invaluable probe for exploring fundamental neuronal processes such as endocytosis, retrograde trafficking a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38b43cca9a3498b5543e5f0dded563bb
https://pub.dzne.de/record/137904

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Human TDP-43 and FUS selectively affect motor neuron maturation and survival in a murine cell model of ALS by non-cell-autonomous mechanisms

Autor: Nicole Wächter, Alexander Storch, Andreas Hermann

Publikováno v: Amyotrophic lateral sclerosis & frontotemporal degeneration 16(7-8), 431-441 (2015). doi:10.3109/21678421.2015.1055275

TAR DNA-binding protein 43 (TDP-43) and fused in sarcoma (FUS) were recently found to cause familial and sporadic amyotrophic lateral sclerosis (ALS). The mechanisms by which mutations within these genes cause ALS are not understood. We established m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c01c2623b0d27e3783ea1c973dd844e4
https://pub.dzne.de/record/138215

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Axonal transport deficit in a KIF5A( -/- ) mouse model

Autor: Ludger Schöls, Evan Reid, Kathrin N. Karle, Diana Möckel

Publikováno v: Neurogenetics
Neurogenetics 13(2), 169-179 (2012). doi:10.1007/s10048-012-0324-y

Hereditary spastic paraplegia (HSP) is a neurodegenerative disorder preferentially affecting the longest corticospinal axons. More than 40 HSP genetic loci have been identified, among them SPG10, an autosomal dominant HSP caused by point mutations in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c1a71f43020a9855b49a6d1461e7b8e
https://pubmed.ncbi.nlm.nih.gov/22466687

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Developmental and functional nature of human iPSC derived motoneurons

Autor: Stefan Liebau, Anja Boeckers, Tobias M. Boeckers, Patrick T Udvardi, Marianne Stockmann, Karl J. Föhr, Georges F. Kuh, Christian Proepper, Leonhard Linta, Alexander Kleger, Albert C. Ludolph, Alexander Storch

Publikováno v: Stem cell reviews and reports 9(4), 475-492 (2011). doi:10.1007/s12015-011-9329-4

One of the major functional properties of the mature motoneuron is its ability to generate and conduct signals from the central nervous system (CNS) to the peripheral muscle cell in order to induce and control muscle contraction [1]. The molecular co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::102ce13fba0f775f7c4c88a099cd0525
https://pubmed.ncbi.nlm.nih.gov/22048897

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